1. Right Ventricular Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis.
- Author
-
Paternoster G, Bertini P, Innelli P, Trambaiolo P, Landoni G, Franchi F, Scolletta S, and Guarracino F
- Subjects
- Heart Ventricles, Humans, SARS-CoV-2, COVID-19, Hypertension, Pulmonary diagnosis, Ventricular Dysfunction, Right diagnostic imaging
- Abstract
Objective: This systematic review and meta-analysis aimed to describe the features of right ventricular impairment and pulmonary hypertension in coronavirus disease (COVID-19) and assess their effect on mortality., Design: The authors carried out a systematic review and meta-analysis of observational studies., Setting: The authors performed a search through PubMed, the International Clinical Trials Registry Platform, and the Cochrane Library for studies reporting right ventricular dysfunction in patients with COVID-19 and outcomes., Participants: The search yielded nine studies in which the appropriate data were available., Interventions: Pooled odds ratios were calculated according to the random-effects model., Measurements and Main Results: Overall, 1,450 patients were analyzed, and half of them were invasively ventilated. Primary outcome was mortality at the longest follow-up available. Mortality was 48.5% versus 24.7% in patients with or without right ventricular impairment (n = 7; OR = 3.10; 95% confidence interval [CI] 1.72-5.58; p = 0.0002), 56.3% versus 30.6% in patients with or without right ventricular dilatation (n = 6; OR = 2.43; 95% CI 1.41-4.18; p = 0.001), and 52.9% versus 14.8% in patients with or without pulmonary hypertension (n = 3; OR = 5.75; 95% CI 2.67-12.38; p < 0.001)., Conclusion: Mortality in patients with COVID-19 requiring respiratory support and with a diagnosis of right ventricular dysfunction, dilatation, or pulmonary hypertension is high. Future studies should highlight the mechanisms of right ventricular derangement in COVID-19, and early detection of right ventricular impairment using ultrasound might be important to individualize therapies and improve outcomes., Competing Interests: Conflict of interest None., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF