1. Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.
- Author
-
Yang PP, Ye XW, Liu MQ, Yang JX, Feng XL, Li YJ, Zhang K, Liang HW, Yi Y, Wang L, Liu YX, Yang XL, Shi ZL, Feng LQ, Chen L, Xue Y, Pan-Hammarström Q, Wang H, and Zhao Y
- Subjects
- Humans, SARS-CoV-2, Angiotensin-Converting Enzyme 2 chemistry, Protein Binding, Peptides, COVID-19, Nanofibers
- Abstract
The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2., (© 2023 Wiley-VCH GmbH.)
- Published
- 2023
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