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Start Over Author "Büchler, C." Topic crohn's disease
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1. Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue

Author

Schäffler, A., Neumeier, M., Herfarth, H., Fürst, A., Schölmerich, J., and Büchler, C.

Subjects
*ADIPOSE tissues, *CONNECTIVE tissues, *AMINO acid sequence, *MESSENGER RNA
Abstract

Abstract: Genomic structure, promoter region, amino acid sequence and exon-specific primer combinations of the human omentin gene are presented. Omentin mRNA expression differs between omental adipose tissue probes from patients with chronic inflammatory bowel diseases such as Crohn''s disease. Sequence comparisons revealed a 100% identity of omentin with human intelectin. Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn''s disease. [Copyright &y& Elsevier]

Published
2005
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