1. The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry
- Author
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Aardoom, Martine A., Klomberg, Renz C.W., Kemos, Polychronis, Ruemmele, Frank M., Fagbemi, Andrew, Kiparissi, Fevronia, Schweizer, Joachim J., Sebastian, Shaji, Russell, Richard, Torrente, Franco, Van Mill, Marije, De Ridder, Lissy, Croft, Nicholas, Tempia-Caliera, Michela, Lee, Way Seah, Pigott, Anna J., Classen, Martin, Morris, Mary Anne, Muhammed, Rafeeq, Hussey, Seamus, Cananzi, Mara, Menz, Timothy J., Wahbeh, Ghassan T., Van Ommen, C. H.Heleen, Turner, Dan, Focht, Gili, Samsom, Janneke, Veereman, Gigi, Neyt, Mattias, Koletzko, Sibylle, Brückner, Annecarin, Levine, Arie, Weiner, Dror, Griffiths, Anne, Aloi, Marina, Raes, Jeroen, Christiaens, Annick, Walters, Thomas, Walker, Michael, Ruemelle, Frank, Demange, Christine Nguyen, Bigot, Laetitia, and Pediatrics
- Subjects
Pediatrics ,medicine.medical_specialty ,Population ,Disease ,Inflammatory bowel disease ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Prospective Studies ,Registries ,education ,Child ,Venous Thrombosis ,education.field_of_study ,Crohn's disease ,business.industry ,Incidence (epidemiology) ,Incidence ,Gastroenterology ,Anticoagulants ,General Medicine ,Venous Thromboembolism ,medicine.disease ,Inflammatory Bowel Diseases ,Ulcerative colitis ,3. Good health ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Complication ,business ,Cohort study - Abstract
Background and Aims Guidelines regarding thromboprophylaxis for venous thromboembolisms [VTEs] in children with inflammatory bowel disease [IBD] are based on limited paediatric evidence. We aimed to prospectively assess the incidence of VTEs in paediatric-onset IBD [PIBD], characterize PIBD patients with a VTE and identify potential IBD-related risk factors. Methods From October 2016 to September 2020, paediatric gastroenterologists prospectively replied to the international Safety Registry, monthly indicating whether they had observed a VTE case in a patient Results Participation of 129 PIBD centres resulted in coverage of 24 802 PIBD patients. Twenty cases of VTE were identified [30% Crohn’s disease]. The incidence of VTEs was 3.72 (95% confidence interval [CI] 2.27–5.74) per 10 000 person-years, 14-fold higher than in the general paediatric population (0.27 [95% CI 0.18–0.38], p < 0.001). Cerebral sinus venous thrombosis was most frequently reported [50%]. All but one patient had active IBD, 45% were using steroids and 45% were hospitalized. No patient received thromboprophylaxis, whereas according to current PIBD guidelines, this was recommended in 4/20 patients. Conclusion There is an increased risk of VTEs in the PIBD population compared to the general paediatric population. Awareness of VTE occurrence and prevention should be extended to all PIBD patients with active disease, especially those hospitalized.
- Published
- 2021