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Background: Intense pulsed light (IPL), as a therapeutic approach for rosacea, had advantage in removing erythema and telangiectasia and was gradually accepted by rosacea patients, but there have been few studies on economic evaluation of this therapy. Purpose: This study aimed to detect willingness-to-pay (WTP) of IPL treatment for rosacea and to conduct a benefit–cost analysis (BCA) among the Chinese population, so as to provide an economic reference for doctors to make treatment decisions. Materials and Methods: An observational, cross-sectional study assessed respondent's demographic characteristics and willingness-to-pay (WTP) of IPL and rosacea patients' clinical data and Dermatology Life Quality Index (DLQI). WTP was obtained by contingent valuation (CV) method. In brief, contrast figures of three cases treated with IPL (Case1, Case2, and Case3 represented the increasing severity of rosacea) were showed and WTP was inquired. The costs were obtained according the market and compared with WTP (benefits) to get a benefit–cost ratio (BCR). Predictors of cost-effective WTP were identified using the multivariable logistic regression model. Results: A total of 303 rosacea patients and 202 controls were included in the study. The average cost of a single IPL treatment for rosacea was USD 208.04 in Changsha, China. The mean WTP for Case 1, Case 2, and Case 3 was USD 201.57, 214.64, and 221.74, respectively. WTP was statistically lower for Case 1 than that for Case 2 or Case 3 (P< 0.05). The BCRs were 0.85, 1.03, and 1.06 for Case 1, Case 2, and Case 3, respectively. WTP is significantly associated with household monthly income, previous treatment cost, and DLQI after adjustments for demographic characteristics (P< 0.05). Conclusion: IPL is an acceptable treatment for rosacea with moderate to severe erythema. For patients with relatively high income or severely impaired quality of life, IPL is an economically feasible therapy and deserves to be recommended. [ABSTRACT FROM AUTHOR]

The impact of artificial light at night (ALAN) exposure on health has become increasingly prominent. However, little is known about the effect of ALAN exposure on atopic diseases. In this study, a cross-sectional analysis of incoming students was conducted in 5 geographically disperse universities which locate in Changsha (south), Wuhan (central), Xiamen (east), Urumchi (west), and Hohhot (north), respectively. All incoming students who consented to participate were recruited, followed by a health examination and a questionnaire survey. Prevalent atopic diseases were diagnosed by clinicians. Mean ALAN (nanoWatts/cm2/sr) during their adolescence was obtained from the remote sensing observed nighttime light data matching with their residence information, which was obtained from survey. Mixed generalized linear models (log-binomial) were used to estimate the associations, in terms of prevalence ratio (PR) with 95% confidence interval (CI). A total of 20106 participants were included in the analysis. Based on previous work, we chose factors including socioeconomic status, behavioural factors, major air pollutants, and air climatic parameters for adjustment. After full adjustment, the PR for atopic diseases was 1.35 (95% CI: 1.27-1.42; P < 0.001). The effect size of ALAN was the largest for asthma (PR = 1.80; 95% CI: 1.48-2.19; P < 0.001), followed by atopic rhinitis (PR = 1.42; 95% CI: 1.33-1.51; P < 0.001), and atopic dermatitis (PR = 1.20; 95% CI: 1.06-1.35; P = 0.003). Subgroup analyses by covariates showed consistent results. This study revealed that exposure to ALAN during adolescence may contribute to a higher risk of atopic diseases in young adulthood. [ABSTRACT FROM AUTHOR]