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Determining the geochronological framework and geochemical nature of magmatism associated with orogenic processes is crucial to decipher the evolution of orogenic belts. The Himalayan orogen has recorded considerable information regarding deformation, metamorphism, and magmatism related to orogenic processes. Here, we identify four stages of granitic magmatism on the basis of monazite U–Th–Pb dating of rocks from the Lhagoi Kangri dome, north Himalayan antiform, southern Tibet: middle Eocene (42–40 Ma), late Eocene (ca. 36 Ma), Oligocene (ca. 26 Ma), and Miocene (16–13 Ma). The middle Eocene tourmaline-bearing leucogranite is characterized by (1) relatively high SiO 2 (78.7 wt%), Al 2 O 3 (12.6 wt%), and Na 2 O (6.3 wt%) contents; (2) enrichment in light rare earth elements (LREEs), depletion in heavy REEs, high abundances of REEs, and pronounced negative Eu anomalies; and (3) relatively low values of whole-rock Sr Nd isotope compositions (87Sr/86Sr(t) = 0.72101 and εNd(t) = −9.8). And the coeval garnet–bearing two–mica granite has a pronounced negative Eu anomaly (Eu/Eu* = 0.07) and a significate lanthanide tetrad effect (TE 1,3 = 1.46). These geochemical data suggest that these leucogranites underwent fractional crystallization. They provide a robust evidence for that anatexis of the lower crust of Indian plate began at 42–40 Ma in the central Himalayan orogen. The Oligocene and Miocene two–mica granites share broadly similar geochemical characteristics, such as moderate REE contents and weak negative Eu anomalies, and are distinct from the garnet-bearing muscovite leucogranite. Whole-rock Sr Nd isotope compositions of the Oligocene and Miocene leucogranites differ from those of the middle Eocene leucogranites, with higher 87Sr/86Sr(t) ratios (0.73524–0.74188) and lower εNd(t) values (−14.7 to −13.7). These geochemical data indicate that the Oligocene and Miocene leucogranites are products of muscovite-dehydration melting of metasedimentary rocks. The garnet-bearing muscovite leucogranite shows the REE tetrad effect, which suggests that it is more evolved than the coeval two–mica granite. We therefore infer that the variations in age and isotopic characteristics of the studied leucogranites were caused by a change in melt source resulting from the compression–extension evolution of the Himalayan collisional orogenic system. • Four-stage emplacement of leucogranites were identified in the Lhagoi Kangri dome. • The age and isotopic variations of leucogranites result from a change in melt source. • Middle Eocene leucogranites reveal a long-lived anatexis in the Himalayan orogen. [ABSTRACT FROM AUTHOR]