1. Dectin-1 is not required for the host defense to Cryptococcus neoformans.
- Author
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Nakamura K, Kinjo T, Saijo S, Miyazato A, Adachi Y, Ohno N, Fujita J, Kaku M, Iwakura Y, and Kawakami K
- Subjects
- Animals, Cryptococcosis immunology, Cryptococcus neoformans immunology, Dendritic Cells immunology, Gene Deletion, Lectins, C-Type, Membrane Proteins genetics, Membrane Proteins metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins genetics, Nerve Tissue Proteins metabolism, Cryptococcosis prevention & control, Cryptococcus neoformans pathogenicity, Interleukin-12 biosynthesis, Membrane Proteins physiology, Nerve Tissue Proteins physiology
- Abstract
Dectin-1 is known as a sole receptor for beta-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.
- Published
- 2007
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