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Reaction of silver nitrate with 2‐aminobenzothiazole (abbreviated as Habt) in methanol at 45°C gave mononuclear complex of formula [Ag (Habt)2]NO3•CH3OH. The structure of the complex was characterized by infrared (IR) spectra, single crystal X‐ray diffraction, and elemental analysis. X‐ray diffraction analysis indicated that the title complex was crystallized in the triclinic crystal system with space group P–1, in which silver(I) ion was coordinated to two 2‐aminobenzothiazole ligands through the benzothiazol nitrogen atom. Theoretical study of the complex was carried out by density functional theory (DFT) B3LYP method. The antimicrobial effects of the ligand and its silver(I) complex were evaluated by bio‐microcalorimetry on the growth of Schizosaccharomyces pombe (S. pombe). Some quantitative metabolic parameters, such as growth rate constant (k), maximum heat power (Pmax), inhibition ratio (I), and half inhibition concentration (IC50), were derived from the metabolic power–time curves of S. pombe growth. The half inhibition concentration (IC50) of the ligand was calculated to be 2.58 × 10−3 mol L−1. The complex could strongly influence the lag phase of S. pombe. [ABSTRACT FROM AUTHOR]

[Display omitted] • A new cobalt(II) complex was synthesized and characterized. • Theoretical studies using DFT calculations. • The bioactivity of cobalt(II) complex was assessed by bio-microcalorimetry. • The complex displayed much stronger antibacterial activity than Schiff base. • Some thermokinetic parameters (k , P max , t G and Q total) were derived. A new cobalt(II) Schiff-base complex [Co(L) 2 ] was prepared by using equivalent molar of Schiff-base ligand [HL=(E)- N '-(2-hydroxy-3-methoxybenzylidene)isonicotinohydrazide] and CoCl 2 ·6H 2 O. The structure of the complex was characterized by single-crystal X-ray diffraction, IR, ESI-MS, elemental analysis and DFT method. X-ray crystal structure analysis showed that the complex crystallized in space group Pbca, with two symmetry-independent molecules. The experimental vibrational bands(IR) have been discussed and assigned based on DFT calculations. The antibacterial activity of Schiff base and its complex against S. pombe were assessed by bio-microcalorimetry at 32 °C. Some thermokinetic parameters (k , P max, t G and Q total) were derived from the metabolic power–time curves, and their quantitative relationship with the concentration were analyzed. The half inhibition concentration (IC 50) of Schiff base and its complex were calculated to be 1.18 × 10−2 mol L−1 and 1.07 × 10−3 mol L−1, respectively. The inhibition effect of the complex showed much stronger than that of Schiff base. [ABSTRACT FROM AUTHOR]