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In the present investigation, we report the synthesis and characterization of three novel nickel(II) [Ni(L)2] (1) and copper(II) [Cu(L)2] (2a) and [Cu(L)2] (2b) complexes, which are made through the coordination of (E)-1-(2-methoxybenzylidine)-4-phenylethiosemicarbazone (HL) as bidentate N,S-ligand. Several modern techniques including experimental electronic and fluorescence spectroscopy, single-crystal X-ray crystallography, molecular docking and BSA-binding are used to characterize the isolated coordination compounds. X-ray crystallography, FT-IR and UV–visible spectra agree with the observed crystal structures. The crystallographic and spectroscopic studies confirmed that these complexes display four-coordinate square-planar trans-[MN2S2] coordination geometry, whose central metal(II) atom lies on the center of symmetry. Complexes 1 and 2a crystallized in the orthorhombic system of the space group Pbca whereas 2b crystallized in the monoclinic system of P21/c. The binding affinity of complexes towards bovine serum albumin (BSA) was determined by UV–visible and fluorescence spectrophotometric methods. The cytotoxic/antiproliferative potential of the synthesized compounds on human cell lines was also investigated by MTT assay. [ABSTRACT FROM AUTHOR]

[Ni(L) 2 ] 1 and [Cu(L) 2 ] 2 [HL = 2-((E)-(2-methoxyphenylimino)methyl)-4,6-dichlorophenol] Schiff base complexes have been successfully synthesized and were characterized by FT-IR, UV–Vis, fluorescence spectroscopy and thermogravimetric analysis. The crystal structures of the two complexes were determined through X-ray crystallography. Its inhibitory activity against Helicobacter pylori urease was evaluated in vitro and showed strong inhibitory activity against H. pylori urease compared with acetohydroxamic acid (IC 50 = 42.12 μmolL −1 ), which is a positive reference. A docking analysis using the AutoDock 4.0 program could explain the inhibitory activity of the complex against urease. [ABSTRACT FROM AUTHOR]

Two new Schiff bases 2-(( E )-(4-bromo-2-chlorophenylimino)methyl)-4-bromophenol(HL 1 ) and1-(( E )-(4-bromo-2-chlorophenylimino)methyl)naphthalene-2-ol (HL 2 ) and their new nickel (II) complexes [Ni(L 1 ) 2 ]·DMF(1) and [Ni(L 2 ) 2 ] (2) have been synthesized and characterized by various physico- chemical and spectroscopic methods. The solid-state structures of synthesized compounds were determined by single crystal X-ray crystallography, which revealed square planar geometry around Ni (II) ion. Infrared spectra, UV–Vis, thermal analysis and magnetic susceptibility measurements agreed with the observed crystal structures. The ligand (HL 1 ) crystallized in the Orthorhombic system of the space group Pbca,a = 7.5485(4)Å, b = 11.5514(5) Å, c = 30.1370(14)Å, α = 90°, β = 90°, γ = 90°and Z = 8. Complex[Ni(L 1 ) 2 ]·DMF(1) crystallized in the Triclinic system of the space group P-1 , a = 8.9954(3) Å, b = 9.4593(4) Å, c = 13.2657(5) Å, α = 101.478°, β = 99.595°, γ = 117.651°and Z = 2, whereas complex [Ni(L 2 ) 2 ]·(2) crystallized in the Monoclinic system of the space group P 2 1 / c, a = 9.301(9)Å, b = 12.149(8)Å, c = 13.792(10)Å, α = 90°, β = 106.35(4).°, γ = 90°and Z = 2. The Schiff bases (HL 1 and HL 2 ) behaved as monobasic bidentate ligands possessing N and O donor atoms. The SOD activities of HL 1 and its Ni (II) complex[Ni(L 1 ) 2 ]·DMF(1) have been measured using xanthine-xanthine oxidase as a source of superoxide radical and NBT assay as O 2 − scavenger. In vitro antimicrobial activities of the Ni(II) complexes (1) and (2)against Bacillus cereus and Staphylococcus aureus as Gram + ve and Salmonella typhi, Klebsiella pneumonia and Escherichia coli as Gram-ve species have been investigated comparing with the Schiff base ligands (HL 1 and HL 2 ). [ABSTRACT FROM AUTHOR]