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A novel chain-like coordination polymer [CuLCl2(DMF)]n (1) with helical double chains was synthesized using flexible bis(pyridylurea) ligand 1,1 ′ -[oxybis(2,1-phenylene)] bis(3-pyridin-3-ylurea) (L) under solvothermal conditions and characterized by single-crystal X-ray diffraction and elemental analysis. A green grinding processing method was used to produce the required complex 1 nanorods, which featured good water dispersibility. The protective effect of the compound was evaluated in vivo, following the construction of the coronary heart disease (CHD) rat model and nano 1 treatment. The cardiac function promoted by nano 1 was measured using the left ventricular systolic diameter (LVID) and left ventricular ejection fraction (LVEF). The anti-oxidative activity of nano 1 was determined with an ROS detection kit. In addition, the interaction between the Cu(II) complex with protein NF- κ B was examined by molecular docking. A novel coordination polymer [CuLCl2(DMF)]n (1) was synthesized and characterized by single-crystal X-ray diffraction. The protective effect of the compound was evaluated in vivo, following the construction of the coronary heart disease (CHD) rat model and compound treatment. [ABSTRACT FROM AUTHOR]

A new mixed‐ligand coordination polymer {[Co(Hbidc)(2,2′‐bpy)(H2O)2]⋅1.5H2O}n (1) has been successfully prepared by the reaction of Co(NO3)2⋅6H2O, 2, 2′‐bipyridine (2,2′‐bpy) as well as benzimidazole‐5, 6‐dicarboxylic acid (H3bidc) in the mixed solvent of water and DMA under solvothermal conditions. Furthermore, a mechanical grinding method was used to produce the nanostructure 1 with the average size of 263 nm. The integrity of H9 C2 cardiomyocytes cell membrane after nano 1 treatment was detected by LDH detection. After nano 1 incubation, the inflammatory level in the H9 C2 cardiomyocytes was evaluated by western blot and ELISA measurement. In addition, the ROS accumulation in H9 C2 cardiomyocytes after nano 1 treatment was determined by H2DCFDA detection assay. Finally, possible interactions between the studied complex 1 and protein has been probed using molecular docking simulation. [ABSTRACT FROM AUTHOR]