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Organic crystals are generally considered to be brittle, inelastic materials, which pose challenges for application in flexible devices. Inspired by α helical proteins for their key structural role in flexible hair, here, we describe the construction of a spring-like hydrogen bonded network through the self-assembly of a-OH/e-OH cyclohexanol derivatives. [ABSTRACT FROM AUTHOR]

Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals. [ABSTRACT FROM AUTHOR]

Four cocrystals of the anti-tuberculosis drug pyrazinamide (PZA) with adipic acid (1), sebacic acid (2), trans-aconitic acid (3), and citric acid (4) were successfully designed and synthesised. Their structures were determined by single-crystal X-ray diffraction, in which 1 and 2 displayed one-dimensional chain structures, while 3 and 4 formed two-dimensional hydrogen-bonded frameworks between PZA and the coformers. The equilibrium solubility and intrinsic dissolution rate (IDR) of the four cocrystals and PZA itself were then determined. The results demonstrate that 3 and 4 exhibit superior solubility and IDR relative to PZA. [ABSTRACT FROM AUTHOR]