1. Quality assessment of Curcuma dietary supplements: Complementary data from LC-MS and 1 H NMR.
- Author
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Sorng S, Balayssac S, Danoun S, Assemat G, Mirre A, Cristofoli V, Le Lamer AC, Jullian V, Gilard V, Fabre N, Martino R, and Malet-Martino M
- Subjects
- Chromatography, Liquid, Diarylheptanoids, Dietary Supplements analysis, Plant Extracts chemistry, Proton Magnetic Resonance Spectroscopy, Tandem Mass Spectrometry, Curcuma chemistry, Curcumin analysis
- Abstract
Due to the numerous potential health benefits of Curcuma, turmeric dietary supplements (DS) are among the top selling products. To assess the quality of these formulations, thirty Curcuma DS along with five standard Curcuma rhizomes were analyzed with UHPLC-MS and
1 H NMR. The chemometric treatment of the UHPLC-MS spectra showed a significant variability of their chemical composition that was confirmed by1 H NMR which allowed the absolute quantification of the Curcuma major bioactive components, i.e. curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin), and turmerones (aryl-, α- and β-) as well as piperine, a commonly associated curcumin bioavailability enhancer: respectively 3.5-556, 0-8.6, 0.18-8.1 mg/capsule or tablet. The comparison of the actual and claimed quantities of curcuminoids and piperine showed that 58% of the DS contained the expected amounts of actives., (Copyright © 2022 Elsevier B.V. All rights reserved.)- Published
- 2022
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