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Abstract: This work reports on the synthesis of tetrakis‐[(thiophineethoxy) phthalocyaninato] indium(II) chloride (3). The photophysical behavior of complex 3 was compared to that of the Zn derivative (tetrakis‐[(thiophineethoxy) phthalocyaninato] zinc(II) (complex 2)). The compounds were interacted with gold‐speckled silica (GSS) nanoparticles via Au–S self assembly to afford the conjugates (2–GSS and 3–GSS). The photophysicochemical behavior of the compounds and their conjugates were assessed. The conjugates afforded a decrease in fluorescence quantum yields and lifetimes with improved triplet and singlet oxygen quantum yields in comparison with complexes 2 and 3 alone. The complexes and their conjugates could serve as good candidates for photodynamic therapy. [ABSTRACT FROM AUTHOR]

The syntheses of zinc(II) tetra–[3–(4–phenoxy) (propanoic acid) phthalocyanine] ( 2 ) and zinc(II) mono–[3–(4–phenoxy) (propanoic acid) phthalocyanine ( 3 ) are reported in this work. Compounds 2 and 3 were covalently linked to glutathione capped silver (AgNPs–GSH), gold (AuNPs–GSH) and silver-gold alloy (Ag 3 Au 1 NPs–GSH) nanoparticles (NPs) via an amide bond formation to afford the conjugates: 2 –AgNPs–GSH, 3 –AgNPs–GSH, 2 –AuNPs–GSH, 3 –AuNPs–GSH, 2 -Ag 3 Au 1 NPs–GSH and 3 -Ag 3 Au 1 NPs–GSH. The photophysicochemical behaviours of the compounds and their conjugates with NPs were assessed in solution. The conjugates afforded a decrease in fluorescence quantum yields and lifetimes with improved triplet quantum yields in comparison to the compounds. Accordingly, the AgNPs and AuNPs conjugates with the compounds afforded high singlet quantum yields. On the contrary, the conjugates of the alloy afforded decreased singlet quantum yields probably due to the screening effect. The compounds and their conjugates with NPs could serve as a viable and efficacious photosensitizer for photodynamic therapy. [ABSTRACT FROM AUTHOR]