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voltammetry (SWV) at a hanging mercury-drop electrode (HMDE) in electrolytes of different pH. Ezetimibe gave rise to a single voltammetric peak in the potential interval from -1290 to - 1322 mV depending on ezetimibe concentration within the entire pH range (4.0 – 10.0) in K2HPO4 – Na2B4O7 (25:25) (v/v) buffer. The well-defined peaks were observed at the frequency of 50 Hz, amplitude of 20 mV, potential increment of 3 mV. The developed method was validated according to the ICH guideline and found to be linear, sensitive, specific, precise, accurate, rugged and robust. Limit of detection (LOD) and limit of quantification (LOQ) were found 0.099 μg mL-1 and 0.30 μg mL-1 respectively. The linearity range of ezetimibe was 0.33 – 6.54 μg mL-1 under the optimum conditions. The developed method was applied successfully for the determination of ezetimibe in tablet dosage form. Also electrochemical behaviours of ezetimibe were investigated. As a results of cyclic voltammetry (CV) and SWV experiments, the reduction mechanism included 2 electrons and 2 protons, and further more, reduction current of ezetimibe was diffusion controlled and the electrode reaction was found to be irreversible by using CV, chronoamperometry (CA) and choronocoulometry (CC) methods. Using these electrochemical techniques diffusion coefficient (D), rate constant for electron transfer (kf) and rate constant of following chemical reaction (k) relating to ezetimibe’s reduction reaction was calculated. It was found out that the reduction reaction occured according to EC mechanism and possible reduction mechanism was proposed.

Ezetimib (EZE), kolesterol absorpsiyon inhibitörü antihiperlipidemik ajanların ilk üyesidir. Bu tez çalışmasında, EZE'nin farmasötik preparatlardan miktar tayini amacıyla kare dalga voltametrisi (SWV), kare dalga adsorptif sıyırma voltametrisi (SWAdSV) ve diferansiyel puls adsorptif sıyırma voltametrisi (DPAdSV) gibi basit ve güvenilir elektroanalitik yöntemler uygulanmıştır. Öncelikle EZE tayini için şartlar optimize edilmiştir. Bunun sonucunda SWV yöntemi için 50 Hz'lik frekans, 3 mV'luk adım yüksekliği, 20 mV'luk puls genliğinde; SWAdSV yöntemi için - 800 mV'luk biriktirme potansiyeli, 4 mV'luk adım yüksekliği, 15 Hz'lik frekans, 25 mV'luk puls genliği, 15 s biriktirme süresinde; DPAdSV yöntemi için - 850 mV'luk birikirme potansiyeli, 20 mV / s'lik tarama hızı, 50 mV'luk puls genliği ve 15 s'lik biriktirme süresinde en iyi pikler elde edilmiştir. Gözlenebilme sınırı (LOD) ve alt tayin sınırı (LOQ) sırasıyla SWV yöntemi için 0.099 µg mL-1 ve 0.298 µg mL-1; SWAdSV yöntemi için 11.53 ng/mL ve 31.73 ng/mL; DPAdSV yöntemi için 20.26 ng/mL ve 62.46 ng/mL olarak elde edilmiştir. Doğrusallık aralıkları SWV yöntemi için 0.33 - 6.54 µg/mL; SWAdSV yöntemi için 33 - 596 ng/mL; DPAdSV yöntemi için 66 - 400 ng/mL olarak bulunmuştur. EZE derişimine bağlı olarak SWV yönteminde [(-1290) ? (-1322)] mV arasında SWAdSV yönteminde [(-1236) ? (-1252)] mV arasında ve DPAdSV yönteminde [(-1190) ? (-1210)] mV arasında indirgenme piki gözlenmiştir. Geliştirilen yöntemler ?International Conference on Harmonisation of Technical Requirements for Registration of Pharmacueticals for Human Use? (ICH)'a göre valide edilmiş ve doğrusal, duyarlı, özgün, doğru, kesin, sağlam ve tutarlı bulunmuştur. Bu yöntemler EZE içeren farmasötik preparatların analizine başarıyla uygulanmıştır. Elde edilen sonuçlar kaynaklarda verilen UV-spektrofotometrik yöntemle karşılaştırılmış ve istatistiksel olarak anlamlı bir fark bulunmamıştır. Ayrıca EZE'nin elektrokimyasal davranışları incelenmiştir. Bunun için yapılan dönüşümlü voltametri (CV) ve SWV deneylerinin sonucunda indirgenme mekanizmasının 2 elektronlu ve 2 protonlu olduğu, CV, kronoamperometri (CA) ve kronokulometri (CC) yöntemleri uygulanarak EZE'in indirgenme akımının difüzyon kontrollü ve elektrot tepkimesinin tersinmez olduğu bulunmuştur. İndirgenme tepkimesinin EC mekanizmasına göre yürüdüğü tespit edilmiş ve olası indirgenme mekanizması önerilmiştir. Elektrokimyasal tekniklerle EZE'in indirgenme tepkimesine ait difüzyon katsayısı (D), elektron aktarım hız sabiti (kf) ve kimyasal tepkimenin hız sabiti (k) hesaplanmıştır., Ezetimibe (EZE) is the first of a new class of antihyperlipidemic agents, the cholesterol ? absorption inhibitors. In this thesis study, a simple and reliable electroanalytical methods such as square wave voltammetry (SWV), square wave adsorptive stripping voltammetry (SWAdSV) and diferansiyel puls adsorptive stripping voltammetry (DPAdSV) are applied to estimate the amount of EZE in tablets. Firstly, the developed methods were optimized for the determination of EZE. The well-defined peaks were observed at the frequency of 50 Hz, amplitude of 20 mV, potential increment of 3 mV for SWV; at accumulation time of 15 s, accumulation potential of ? 800 mV, frequency of 15 Hz, amplitude of 25 mV, potential increment of 4 mV for SWAdSV; at accumulation time of 15 s, accumulation potential of ? 850 mV, scan rate of 20 mV / s and amplitude of 50 mV for DPAdSV. Limit of detection (LOD) and limit of quantification (LOQ) were found 0.099 µg/mL and 0.298 µg/mL for SWV, 11.53 ng/mL and 31.73 ng/mL for SWAdSV and 20.26 ng/mL and 62.46 ng/mL for DPAdSV respectively. The linearity ranges of EZE for SWV, SWAdSV and DPAdSV were found 0.33 - 6.54 µg/mL, 33 - 596 ng/mL and 66 - 400 ng/mL respectively. EZE gave rise to a single voltammetric peak in the potential interval from - 1290 to -1322 mV for SWV, from - 1236 to - 1252 mV for SWAdSV and from - 1190 to - 1210 mV for DPAdSV depending on EZE concentration. The developed methods were validated according to the ?International Conference on Harmonisation of Technical Requirements for Registration of Pharmacueticals for Human Use? (ICH) guideline and found to be linear, sensitive, specific, accurate, precise, accurate, robust and rugged. The methods were applied successfully for the determination of EZE in tablet dosage form. The data were compaired with ones obtained from the UV-spectrophotometric method given in the literature and no significant difference was found statistically. Also electrochemical behaviours of EZE were investigated. As a results of cyclic voltammetry (CV) and SWV experiments, the reduction mechanism included 2 electrons and 2 protons, and further more, reduction current of EZE was difusion controlled and the electrode reaction was found to be irreversible by using CV, chronoamperometry (CA) and choronocoulometry (CC) methods. It was found out that the reduction reaction occured according to EC mechanism and possible reduction mechanism was proposed. Using electrochemical techniques diffusion coefficient (D), rate constant for electron transfer (kf) and rate constant of chemical reaction (k) relating to EZE?s reduction reaction was calculated.

Phenylketonuria (PKU) is a critical disease in the disorder of amino acid metabolism, which mostly emerges in children. The most common method used in PKU treatment is the detection of L-phenylalanine (PHEA) as the biomarker of PKU. In the present work, a new molecularly imprinted electrochemical electrode based on WS2 nanoflowers (NFs) on N,B-doped graphene (WS2 NFs/N,B-GR) is presented for PHEA assay in milk samples. First of all, WS2 NFs/N,B-GR was synthesized via a high-efficiency hydrothermal synthesis. Cyclic voltammetry was applied to the electrochemical cell, including PHEA as a template molecule and pyrrole as a monomer, to form PHEA-imprinted electrochemical electrodes. Then, the structural and morphological features of WS2 NFs and WS2 NFs/N,B-GR were investigated in detail by various analytical methods. The limit of quantification and limit of detection values were obtained as 1.0 × 10-11 and 3.0 × 10-12 M, respectively, by a PHEA-imprinted electrochemical electrode. Finally, a PHEA-imprinted electrochemical sensor having a high degree of selectivity, stability, and reusability is presented in the literature for early diagnosis of PKU. © 2022 American Chemical Society. All rights reserved.

WOS: 000456760700070, 30606580, beta-Agonists are illegally consumed in various products such as food and animal and effect the nutrition distribution owing to change of body fat. In addition, they result in acute poisoning and several symptoms such as muscular tremors and nervousness. A new electrochemical approach based on two-dimensional hexagonal boron nitride (2D-hBN) nanosheets decorated functionalized multi-walled carbon nanotubes (f-MWCNTs) was presented for simultaneous determination of beta-agonists such as phenylethanolamine A (PEA), clenbuterol (CLE), ractopamine (RAC) and salbutamol (SAL) in urine samples. X-ray diffraction (XRD) method, Raman spectroscopy, scanning electron microscope (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used characterizations of nanomaterials. After that, 2D-hBN/f-MWCNTs nanocomposite modified glassy carbon electrode (GCE) was prepared for simultaneous determination of beta-agonists. 1.0 x 10(-12)-1.0 x 10(-8) M and 1.0 x 10(-13) M were founded as the linearity range and the detection limit (LOD) for PEA, CLE, RAC and SAL. Finally, the prepared electrochemical sensor was used for urine sample analysis in presence of ascorbic acid (AA) and uric acid (UA).

WOS: 000487854600001, Electrochemical recognition based on Au@nitrogen-doped carbon quantum dots@Ag core-shell (Au NPs@NCDS@Ag NPs) composite including molecular imprinted polymer (MIP) was presented for metobromuron (MBN) detection. Firstly, novel triple-layered core-shell structure including gold nanoparticles core, nitrogen-doped carbon quantum dots interlayer and silver nanoparticles outside shell was synthesized by the reduction of chloroauric acid (HAuCl4), silver nitrate (AgNO3) in the presence of NCDS. Secondly, MBN imprinted polymer on Au NPs@NCDS@Ag NPs composite was electrochemically performed in the presence of pyrrole and MBN via cyclic voltammetry (CV). Fourier-transform infrared spectroscopy (FTIR), transmission electron microscope (TEM), energy-dispersive x-ray (EDX) spectroscopy, x-ray diffraction (XRD) method and electroanalytical methods such as CV, chronoamperometry (CA), electrochemical impedance spectroscopy (EIS) were performed for characterizations of core-shell structure. MBN imprinted electrode showed high electrocatalytic performance and the linear range of 1.0 x 10(-12)-2.0 x 10(-9) M and detection limit (LOD) of 2.0 x 10(-13) M were obtained. (C) 2019 The Electrochemical Society.

The detection of acute myocardial infarction directly depends on the concentration of the cardiac troponin I (CTnI) in human blood plasma. In this study, the sensitive, selective, and fast sandwich-type electrochemical CTnI immunosensor was developed by using nitrogen and boron-dopped graphene quantum dots -as electrode platform and two-dimensional Ce-dopped SnO2/SnS2 (Ce-SnO2/SnS2) as signal amplification. In preparation of electrochemical CTnI immunosensor, the coordinated covalent bond between capture antibody (anti-CTnI-Ab1) and nitrogen and boron-dopped graphene quantum dots as electrode platform led to immobilization of anti-CTnI-Ab1, and the strong esterification between the secondary antibody (anti-CTnI-Ab2) and thioglycolic acid-modified Ce-SnO2/SnS2 resulted in antiCTnI-Ab2 conjugation. Finally, the resultant electrochemical CTnI immunosensor was formed via antigenantibody interaction. High-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, UV-Vis spectroscopy and Raman spectroscopy, as well as some electrochemical characterization techniques, including cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy were used to characterize the prepared immunosensor. The detection limit of CTnI in plasma samples was calculated as 2.00 fg mL-1, making it an effective tool for acute myocardial infarction testing. (c) 2021 Elsevier Ltd. All rights reserved.

In this study, an ultra-sensitive electrochemical immunosensor for PSA detection was designed. Firstly, gold nanoparticles (AuNPs)/p-aminothiophenol (ATP) functionalized graphene oxide (GO) composite (AuNPs-ATPGO) was constructed and modified to glassy carbon electrode (AuNPs-ATPGO/GCE). AuNPs-ATPGO/GCE was utilized as immunosensor platform to increase the amount of PSA antibody1 (Ab1). After that, self-assembled delaminated MXene-gold nanoparticles (d-Ti3C2TX MXene@AuNPs) was used to label PSA seconder antibody2 (Ab2) as signal amplification. The prepared AuNPs-ATPGO, d-Ti3C2TX MXene@AuNPs and electrochemical immunosensor was charecterized by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), scanning electron microscope (SEM), x-ray diffraction (XRD) method, x-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR). The linearity range and detection limit (LOD) were obtained as 0.01–1.0 pg mL-1 and 3.0 fg mL-1, respectively. © 2020 Elsevier B.V.

WOS: 000531201500044, Chlorpyrifos (CHL) is one of the most frequently used broad-spectrum organophosphate insecticides. Especially, its incorrect and uncontrolled usage cause public concern about food and environment safety. In this report, a new molecularly imprinted quartz crystal microbalance (QCM) sensor on delaminated sulfur-doped MXene (d-S-Ti3C2TX MXene) was prepared for CHL. The structures of the bare MAX phase (Ti3AlC2), sulfur-doped MAX phase (S-Ti3AlC2), wrinkled sulfur-doped MXene (S-Ti3C2TX MXene) and d-S-Ti3C2SX MXene were highlighted by scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and X-ray diffraction (XRD). The CHL imprinted QCM sensor was prepared in the presence of MAGA and CHL in 2 : 1 molar ratio. From the analytical results 1.0 x 10(-12)-1.0 x 10(-10) M and 3.0 x 10(-13) M were found to be the linearity range and detection limit (LOD), respectively. Furthermore, the CHL imprinted QCM sensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the imprinted sensor was applied to orange juice samples, and a high recovery was obtained.

Organochlorine compounds such as gamma-lindane (?-LND) are very toxic and important ubiquitous contaminants in the environment. In this report, new molecular imprinted sensor on polyoxometalate (POM, H3PW12O40)/carbon nitride nanotubes (C3N4 NTs) composite were prepared for ?-LND detection. The structures of C3N4 NTs and H3PW12O40/C3N4 NTs composite were highlighted by scanning electron microscope (SEM), transmission electron microscopy (TEM), energy dispersive x-ray analysis (EDX), x ray photoelectron spectroscopy (XPS), fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). ?-LND imprinted electrode was prepared in the presence of 100.0 mM pyrrole containing 25.0 mM ?-LND. The analytical results have revealed that 1.0 × 10?10?1.0 × 10?8 M and 2.0 × 10?11 M were found as linearity range and the detection limit (LOD). Furthermore, the developed sensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the imprinted sensor was applied to orange juice samples having high recovery. © 2020 Elsevier B.V.

Diazinon [O,O-diethyl O-(2-isopropyl-6-methylpyrimidin4-yl) thiophosphate] (DIA) is a significant organophosphorus insecticide in agricultural applications. Thus, sensitive analytical methods development is important for a healthy lifestyle. In this work, the electrochemical detection of DIA molecule in fruit juice samples by using gold nanoparticles (AuNPs) incorporated polyoxometalate (POM)/two-dimensional hexagonal boron nitride (2D-hBN) nanosheets and molecularly imprinted polymer (MIP) was reported. To characterize as-prepared nanomaterials scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and energy dispersive X-ray analysis (EDX) techniques were performed. The electrochemical behavior of the electrodes was examined by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). The as-fabricated DIA imprinted electrode displayed a wide linear range and highly sensitive response to DIA. Moreover, the detection limit (LOD) found to be 3.0 10-12 M. The modified sensor.was successfully used for recognition of DIA in fruit juices. © 2020 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.

Septicemia, also known as sepsis, refers to a systemic inflammatory response syndrome and becomes the dominant reason of mortality for seriously diseases. Procalcitonin (PCT), the peptide precursor of the hormones, is a key biomarker of septicemia in the diagnosis and detection of bacterial inflammation. In this study, an ultra-sensitive sandwich type electrochemical immunosensor for PCT detection was constructed. Firstly, delaminated sulfur-doped MXene (d-S-Ti3C2TX MXene) modified glassy carbon electrode (GCE) including gold nanoparticles (AuNPs) was utilized as immunosensor platform to increase the amount of PCT antibody1 (Ab1). After that, carboxylated graphitic carbon nitride (c-g-C3N4) was used to label PCT Ab2 as signal amplification. The structure of electrochemical immunosensor was highlighted by x-ray diffraction (XRD) method, scanning electron microscope (SEM), transmission electron microscopy (TEM), x-ray photoelectron spectroscopy (XPS), fourier transform infrared spectroscopy (FTIR), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Herein, c-g-C3N4 not only has excellent catalytic activity toward H2O2 for signal amplification, but also can be directly utilized as redox probe. The analytical results have revealed that 0.01 - 1.0 pg mL-1 and 2.0 fg mL-1 were found as linearity range and limit of detection (LOD). Furthermore, the validated electrochemical immunosensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the immunosensor was applied to plasma samples having high recovery. © 2020 Elsevier B.V.

Antigen galectin-3 (GL-3), a member of ß-galactoside proteins indicates cardiac fibrosis and is a significant biomarker for monitoring heart failure risk and death risk. In this study, a novel sensitive amperometric method for antigen GL-3 detection is developed based on gold nanoparticle-functionalized graphitic carbon nitride nanosheets (g-C3N4@Au NPs) as the sensor platform and Ti-based metal organic framework (Ti-MOF, NH2-MIL-125)@covalent organic frameworks (COFs) composite for the signal amplification. The Ti-MOF@COF composite not only facilitates the penetration of antibody proteins into pore channels, but also the highly stable antigen-antibody interactions. The prepared sensor platform and signal amplification material are characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) method, X-ray photoelectron spectroscopy (XPS), UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The amperometric technique is utilized to achieve antigen GL-3 detection in plasma samples. The immunosensor demonstrates a wide linearity range (0.0001-20.0 ng mL-1) and a low detection limit (0.025 pg mL-1). Finally, the prepared immunosensor shows high stability and selectivity under optimum conditions. © 2020 The Royal Society of Chemistry.

WOS: 000441400000076, Serotonin (SER) is the important neurotransmitter and its amount in human body can affect the human life. The low level results in anxiety and carcinoid syndrome. Its high level causes crucial toxicity. Molecularly imprinted approach was used in designing a new electrochemical sensor for serotonin (SER) detection in urine samples. The sensor was prepared based on graphene quantum dots (GQDs) incorporated two-dimensional (2D) hexagonal boron nitride (2D-hBN) nanosheets. All nanomaterials' formation and properties were highlighted with scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) method, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). SER imprinted voltammetric sensor was improved in presence of 80.0 mM phenol containing 20.0 mM SER by CV. 1.0 x 10(-12)-1.0 x 10(-8)M and 2.0 x 10(-13)M were founded as the linearity range and the detection limit (LOD). SER imprinted glassy carbon electrode (GCE) was used for urine sample analysis in presence of the other competitor agents such as dopamine (DOP), tryptophan (TRY) and norepinephrine (NOR). The sensor was also investigated for stability and selectivity.

WOS: 000431786800117, Phenylethanolamine A (PEA) is used illegally and deposited in animal tissues. Due to the reason, it causes acute poisoning and symptoms of muscular tremors, nervousness. In present article, Ru@Au core-shell nanoparticles (Ru@Au NPs) involved in carbon nitride nanotubes (C3N4 NTs) functionalized graphene quantum dots (GQDs) nanocomposite based molecular imprinted polymer (MIP) was formed for PEA recognition. Firstly, C3N4 NTs@GQDs nanocomposite was prepared by means of hydrothermal treatment. Secondly, this nanocomposite was functionalized with 2-aminoethanethiol (AET) via the affinity of gold-sulfur for binding Ru@Au NPs. After that, PEA imprinted voltammetric sensor was prepared in presence of 100.0 mM phenol as monomer containing 25.0 mM PEA by cyclic voltammetry (CV). All nanomaterials' formation and properties were highlighted with scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray analysis (EDX), raman spectroscopy, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). 1.0 x 10(-12) -1.0 x 10(-9) M and 2.0 x 10(-13) M were founded as the linearity range and the detection limit (LOD). Finally, PEA imprinted glassy carbon electrode (GCE) was used for urine sample analysis in presence of the other competitor agents such as clenbuterol (CLE), ractopamine (RAC) and salbutamol (SAL). In addition, the stability and repeatability of prepared sensor was investigated. (C) 2018 The Electrochemical Society., Scientific and Technological Research Council of Turkey (TUBITAK) [116Z153]; TUBITAK, This work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK), with project number 116Z153. We thank TUBITAK for the financial support.

WOS: 000488418800059, The presence of epinephrine is crucial factor relating to several chronic diseases such as hypertension and myocardial infarction. Due to these significant problems, electrochemical recognition based on graphitic carbon nitride/N-doped carbon dots composite (g-C3N4/NCDS) and molecularly imprinted polymer was presented for epinephrine detection in this study. Fourier-transform infrared spectroscopy, scanning electron microscope, transmission electron microscope, x-ray diffraction method and electroanalytical methods such as electrochemical impedance spectroscopy and cyclic voltammetry were performed for characterizations of nano materials. After that, epinephrine imprinted voltammetric sensor on graphitic carbon nitride/N-doped carbon dots composite was carried out in presence of 100.0 mM pyrrole containing 25.0 mM epinephrine via cyclic voltammetry. Epinephrine imprinted electrode showed high sensitivity for epinephrine recognition in wide linear range of 1.0 x 10(-12) - 1.0 x 10(-9) M and detection limit (LOD) of 3.0 x 10(-13) M. Epinephrine imprinted sensor was applied to urine samples for epinephrine analysis.

WOS: 000461526200030, 30776616, An effective SPR nanosensor based on core-shell nanoparticles (Ag@AuNPs) incorporated hexagonal boron nitride (HBN) nanosheets and molecularly imprinted polymer (MIP) was presented for etoposide (ETO) detection. Scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD) method, cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM) methods were utilized for all characterizations of nanomaterials and polymer surfaces. ETO imprinted SPR nanosensor based on Ag@AuNPs-HBN nanocomposite was developed in the presence of poly(2-hydroxyethyl methacrylate-methacryloylamidoglutamic acid) [p(HEMA-MAGA)]. The results of the study have revealed that 0.001-1.00 ng mL(-1) (1.70 x 10(-12)-1.70 x 10(-9) M) and 0.00025 ng mL(-1) (4.25 x 10(-13) M) were found as the linearity range and the detection limit (LOD). Furthermore, the prepared SPR nanosensor was examined in terms of stability, repeatability and selectivity. Finally, the imprinted SPR nanosensor was applied to the urine samples having high recovery.

WOS: 000474725800001, Methyl parathion (MP) is an organophosphate chemical agent. Due to low solubility and bioaccumulation, it results in serious health problems. Electrochemical recognition based on graphitic carbon nitride (CN) incorporated hexagonal boron nitride (HBN) nanosheets and molecularly imprinted polymer (MIP) was presented formethyl parathion (MP) detection. Scanning electron microscopy (SEM), X-ray diffraction (XRD) method, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were utilized for characterizations. After that, MP imprinted voltammetric sensor on CN-HBN nanocomposite was carried out in the presence of 100.0 mMpyrrole containing 25.0 mMMP via CV. 1.0 x 10(-12)-2.0 x 10(-9) Mand 2.0 x 10(-13) Mwere found as the linearity range and the detection limit (LOD). Finally, MP imprinted sensor was applied to orange juice samples for MP analysis. (C) 2019 The Electrochemical Society.

WOS: 000460845900007, Organophosphate pesticides are toxic chemicals and not allowed in nearly all countries. It accumulates in water and soil owing to its low solubility and bioaccumulation causing serious health problems. A novel voltammetric sensor approach based on monodisperse boron nitride quantum dots (BNQDs) on graphene oxide (GO) was presented for simultaneous detection of organophosphate pesticides such as methyl parathion (MP), diazinon (DIA) and chiorpyrifos (CHL) in water samples. Scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD) method, x-ray photo electron spectroscopy (XPS), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods were used for all nanomaterials' characterizations. After that, BNQDs/G0 composite modified glassy carbon electrode (BNQDs/GO/GCE) was prepared and 1.0 x 10(-12)-1.0 x 10(-8) M was founded as the linearity range. The limit of detection (LOD) for MP, DIA and CHL was calculated to be 3.1 x 10(-13)M, 6.7 x 10(-14) M and 33 x 10(-14) M, respectively. Finally, the prepared electrochemical sensor was used for water and apple juice samples analysis with high sensitivity and selectivity. (C) 2018 Elsevier B.V. All rights reserved.

WOS: 000457659500053, 30471567, The cardiac Troponin-I (cTnI) is one of the subunits of cardiac troponin complexes and a pivotal biochemical marker of acute myocardial infarction (AMI). Due to its myocardial specificity, cTnI is widely used for the diagnosis of AMI diseases. In this study, a novel imprinted biosensor approach based on boron nitride quantum dots (BNQDs) was presented for cTnI detection in plasma samples. Various characterization methods such as scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used for all characterizations of nanomaterials. After the characterization analysis, cTnI imprinted electrode was developed in the presence of 100.0 mM pyrrole containing 25.0 mM cTnI. After that, the analytical studies of cTnI in plasma samples were performed by using cTnI imprinted biosensor. The results of the study have revealed that 0.01-5.00 ng mL(-1) and 0.0005 ng mL(-1) were found as the linearity range and the detection limit (LOD). Moreover, the selectivity of cTnI imprinted glassy carbon electrode (GCE) was investigated for plasma sample analysis in the presence of other nonspecific and specific proteins including cardiac myoglobin (MYG), bovine serum albumin (BSA) and cardiac troponin T (cTnT), respectively. Furthermore, the prepared biosensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the imprinted biosensor was applied to the plasma samples having high recovery.

WOS: 000427338300002, Ractopamine (RAC) is an important beta-agonist. It improves the growth rate and reduces the fat for animals. It is also utilized as nutrient repartitioning agent. Nonetheless, it is not licensed in many countries and RAC is dangerous for human health when it is used illegally. Thus, the development of the sensitive analytical methods for real samples is crucial. Carbon nitride nanotubes (C3N4NTs)/ionic liquid (ILs) nanocomposite was firstly synthesized for RAC detection in this study. n-hexyl-3-methylimidazolium hexafluoro phosphate was used as ionic liquid. The formation of the surfaces was characterized by scanning electron microscope (SEM), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and x-ray photoelectron spectroscopy (XPS). The linearity range and the detection limit (LOD) for RAC were calculated as 1.0 x 10(-9)-1.0 x 10(-12) M and 1.0 x 10(-13) M, respectively. (C) 2018 Elsevier B.V. All rights reserved., Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [116Z153]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK), This work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK), with project number 116Z153. We would like to thank TUBITAK for the financial support.

WOS: 000431803900132, Cypermethrin ([RS]-alpha-cyano-3-phenoxybenzyl [1RS, 3RS; 1RS, 3SR]-3-[2,2-dichlorovinyl]-2,2-dimethylcyclopropane carboxylate) is a crucial pyrethroid and it is generally used as poison against crop pests, domestic insects and ectoparasites in farmed fish. A new molecular imprinted sensor approach based on core-shell type nanoparticles (Fe@AuNPs) incorporated two-dimensional (2D) hexagonal boron nitride (2D-hBN) nanosheets was presented for cypermethrin (CYP) detection in wastewater samples. All nanomaterials' formation and properties were highlighted with scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) method, energy dispersive X-ray analysis (EDX), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). CYP imprinted voltammetric sensor was improved in presence of 80.0 mM phenol containing 20.0 mM CYP by CV. 1.0 x 10(-13) -1.0 x 10(-8) M and 3.0 x 10(-14) M were founded as the linearity range and the detection limit (LOD). Finally, CYP imprinted glassy carbon electrode (GCE) was used for wastewater sample analysis in presence of the other competitor agents such as deltamethrin (DEL), tetrametrin (TET) and permethrin (PER). In addition, the prepared sensor was investigated in terms of stability and repeatability. (C) 2018 The Electrochemical Society.

WOS: 000447843800001, A new diethylstilbestrol (DES) imprinted sensor approach based on gold nanoparticles (AuNPs) incorporated two-dimensional (2D) hexagonal boron nitride (2D-hBN) nanosheets was presented for DES detection. The methods such as scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) method, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used for all nanomaterials' characterizations. DES imprinted sensor was prepared in presence of 100.0 mM pyrrole containing 25.0 mM DES by CV. The developed method was validated and 5.0 x 10(-12)-1.0 x 10(-8) M and 1.0 x 10(-13) M were founded as the linearity range and the detection limit (LOD). DES imprinted glassy carbon electrode (GCE) was applied in presence of the natural estrogens such as estrone (E1), estradiol (E2) and estriol (E3) and the other agents such as hydroquinone (HYD) and catechol (CAT). (C) 2018 The Electrochemical Society.

WOS: 000418314400044, In the present report, a new voltammetric sensor based on copper oxide nanoparticles involved in 2-(3-acetoxy4-methoxybenzylidenamino)-thiophenol (AMT) ionic liquid (CuO NPs/ILs) was developed for atrazine (ATR) analysis. Firstly, the CuO NPs/ILs modified surface was investigated by using transmission electron microscopy (TEM), X-ray diffraction (XRD), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and energy dispersive X-ray analysis (EDX). The linearity range and the detection limit (LOD) of the prepared sensor were calculated as 1.0 x 10(-11)-2.0 x 10(-9) and 2.0 x 10(-12) M, respectively. Voltammetric sensor was also applied to wastewater samples with high recovery. (C) 2017 Elsevier B.V. All rights reserved.

WOS: 000415771100043, Rutin is a class of flavonoids. Flavonoids have crucial antioxidant and chelating properties and are present in fruits and vegetables. Despite of their elusive metabolism, the enteric absorption reduces plasma oxidant status. Due to these reasons, rutin detection is important based on sensitive method. In the present report, a new electrochemical sensor based on CoFe2O4 nanoparticles ionic liquid nanocomposite was developed for rutin analysis in orange juice samples. Firstly, the structure analysis of prepared nanocomposites was characterized by transmission electron microscopy, cyclic voltammetry, X-ray photoelectron spectroscopy, electrochemical impedance spectroscopy and energy dispersive X-ray analysis. The linearity range and detection limit of the prepared sensor were obtained as 1.0 x 10(-10)-1.0 x 10(-8) and 3.0 x 10(-11) M, respectively. In addition, the voltammetric sensor was applied to orange juice samples with high recovery. (C) 2017 Elsevier B.V. All rights reserved.