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Your search keyword '"Guoshu Xie"' showing total 3 results
Start Over Author "Guoshu Xie" Topic cycloaddition
3 results on '"Guoshu Xie"'

1. One-pot synthesis of tetrahydro-pyrrolobenzodiazepines and tetrahydro-pyrrolobenzodiazepinones through sequential 1,3-dipolar cycloaddition/N-alkylation (N-acylation)/Staudinger/aza-Wittig reactions

Author

Xiaoming Ma, John Mark Awad, Weiqi Qiu, Wei Zhang, Guoshu Xie, and Xiaofeng Zhang

Subjects
010405 organic chemistry, Chemistry, One-pot synthesis, Alkylation, 010402 general chemistry, 01 natural sciences, Pollution, Cycloaddition, 0104 chemical sciences, N acylation, Wittig reaction, 1,3-Dipolar cycloaddition, Environmental Chemistry, Organic chemistry, Green chemistry metrics
Abstract

A new synthetic method for diastereoselective synthesis of tetrahydro-pyrrolo[1,2-d][1,4]benzodiazepines and tetrahydro-pyrrolo[1,2-d][1,4]diazepinones is developed which involves 1,3-dipolar cycloaddition, N-alkylation or N-acylation and Staudinger/aza-Wittig reactions. This one-pot and three-step synthesis of four components gave two different heterocyclic scaffolds. Green chemistry metrics analysis of the reaction process provided favorable results.

Published
2019

2. Sequential decarboxylative [3+2] cycloaddition and Staudinger/aza-Wittig reactions for diastereoselective synthesis of tetrahydro-pyrroloquinazolines and tetrahedro-pyrrolobenzodiazepines

Author

Rachel E. Muriph, Guoshu Xie, John Mark Awad, Xiaoming Ma, Wei Zhang, Xiaofeng Zhang, and Weiqi Qiu

Subjects
010405 organic chemistry, Chemistry, Organic Chemistry, Drug Discovery, Wittig reaction, 010402 general chemistry, 01 natural sciences, Biochemistry, Medicinal chemistry, Cycloaddition, 0104 chemical sciences
Abstract

A method for diastereoselective synthesis of tetrahydro-pyrroloquinazolines and tetrahydro-pyrrolobenzodiazepines is developed through sequential reactions including decarboxylative 1,3-dipolar cycloaddition of non-stabilized azomethine ylides, N-acylation or N-alkylation, and the Staudinger/aza-Wittig reactions.

Published
2020

3. One-pot diastereoselective synthesis of tetrahydroepimino-benzo[b]azocines through sequential [3+2]-cycloaddition and Staudinger-aza-Wittig reactions

Author

Xiaofeng Zhang, Xiaoming Ma, Wei Zhang, John Mark Awad, and Guoshu Xie

Subjects
010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Cycloaddition, 0104 chemical sciences, Reaction sequence, Intramolecular force, Drug Discovery, Wittig reaction, Molecule
Abstract

The one-pot synthesis of tetrahydro-epiminobenzo[b]azocines through a sequential 1,3-dipolar cycloaddition and intramolecular Staudinger-aza-Wittig reaction sequence is reported. This methodology provides a new and efficient approach for medium-sized and bridged nitrogen heterocyclic molecules.

Published
2019

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