1. Synthesis and Biological Evaluation of 1,3,5-Trisubstituted 2-Pyrazolines as Novel Cyclooxygenase-2 Inhibitors with Antiproliferative Activity.
- Author
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Vahedpour T, Kaur J, Hemmati S, Hamzeh-Mivehroud M, Alizadeh AA, Wuest F, and Dastmalchi S
- Subjects
- Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Cell Proliferation drug effects, Cyclooxygenase 2 Inhibitors chemical synthesis, Cyclooxygenase 2 Inhibitors chemistry, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HT29 Cells, Humans, Molecular Docking Simulation, Molecular Structure, Pyrazoles chemical synthesis, Pyrazoles chemistry, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Cyclooxygenase 2 metabolism, Cyclooxygenase 2 Inhibitors pharmacology, Pyrazoles pharmacology
- Abstract
A new series of 1,3,5-trisubstituted 2-pyrazolines for the inhibition of cyclooxygenase-2 (COX-2) were synthesized. The designed structures include a COX-2 pharmacophore SO
2 CH3 at the para-position of the phenyl ring located at C-5 of a pyrazoline scaffold. The synthesized compounds were tested for in vitro COX-1/COX-2 inhibition and cell toxicity against human colorectal adenocarcinoma cell lines HT-29. The lead compound (4-chlorophenyl){5-[4-(methanesulfonyl)phenyl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}methanone (16) showed significant COX-2 inhibition (IC50 =0.05±0.01 μM), and antiproliferative activity (IC50 =5.46±4.71 μM). Molecular docking studies showed that new pyrazoline-based compounds interact via multiple hydrophobic and hydrogen-bond interactions with key binding site residues of the COX-2 enzyme., (© 2021 Wiley-VHCA AG, Zurich, Switzerland.)- Published
- 2021
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