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The positron emission tomography is a technique of medical image of great sensibility and high resolution that requires short-lived positron emitting radionuclides. The most commonly used are 18F and 11C. The main difficulty of these radionuclides is the necessity to install a cyclotron in the site of use or not very far from it. Therefore convenient radionuclides have been researches, among them 68Ga. The availability of this radionuclide from long-lived 68Ge/68Ga generators, which can been used for along time far from the cyclotron location, and the rich coordination chemistry of Ga3+ have allowed to incorporate to the medical practice some radiopharmaceuticals as well as the research of a variety of stables complexes of Ga3+ coupled to biomolecules for diagnostic imaging of cancer and cardiovascular and neurological diseases. The present work is aimed at examining the potentialities of the 68Ga-radiopharmacy. [ABSTRACT FROM AUTHOR]

The work provides arguments for the selection of 18 MeV cyclotron in protons, in its Twin variant. It will be used only for nuclear reactions with these particles in order to ensure the supply of radionuclides in Cuba, for the positron emission tomography (18F mainly) as well as for single photon emission computed tomography (123I, for example), in the future. Data indicating the possibility of supplying 18F-FDG to at least five PET centers are given. This shall allow Cuba to access the one of the most advanced imaging technology, with the consequent benefit for patients suffering from cancer, cardiovascular and neurological diseases. [ABSTRACT FROM AUTHOR]

In the context of the project for the Introduction of Technologies for the Diagnosis and Treatment of cancer in our country, the Cuban Cyclotron Project was carried out, which included the structural design of the building where a medium energy particle accelerator is installed and the rest of equipment and facilities for the production of positron-emitting radiopharmaceuticals, the preparation of the production plan and the development of various stages until the start of operations. It is the first time in Cuba that a center for the production of radiopharmaceuticals of this type is set up, which is subject to compliance with specific radiological safety requirements and good practices so that the facility is safe and sustainable in the future. This paper presents the experience carried out over ten years to design and build a production center that meets the production expectations of the Ministry of Public Health to improve early diagnosis capabilities for cancer and other chronic non-communicable diseases. As a result, a facility has been built in Havana where the first cyclotron in Cuba was launched at the Specialized Center for Diagnosis and Therapy, which has a production capacity to distribute radiopharmaceuticals to the capital and other provinces of the country; as well as export to countries in the region. [ABSTRACT FROM AUTHOR]