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Start Over Author "Xuan Tu" Topic cytochalasin
2 results on '"Xuan Tu"'

1. Effect of Culture Conditions on Metabolite Production of Xylaria sp.

Author

Hongqi Zhang, Zhangshuang Deng, Zhiyong Guo, Yan Peng, Nianyu Huang, Haibo He, Xuan Tu, and Kun Zou

Subjects
Xylaria sp., cryptic natural product, cytochalasin, α-pyrone, xylapyrones, cytotoxicity, Organic chemistry, QD241-441
Abstract

Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1–5 to six new α-pyrone derivatives, xylapyrones A–F (compounds 6–11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1–3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 μM and compounds 4–11 were found to be inactive, with IC50 values >100 μM.

Published
2015
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2. Effect of Culture Conditions on Metabolite Production of Xylaria sp

Author

Kun Zou, Zhiyong Guo, Nianyu Huang, Zhang-Shuang Deng, Xuan Tu, Haibo He, Yan Peng, and Hongqi Zhang

Subjects
Magnetic Resonance Spectroscopy, Stereochemistry, Metabolite, Cell Culture Techniques, Pharmaceutical Science, Xylaria, Xylaria sp, Article, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Biosynthesis, Cell Line, Tumor, Drug Discovery, Humans, Physical and Theoretical Chemistry, Cytotoxicity, Biological Products, Natural product, Xylariales, biology, Organic Chemistry, Hep G2 Cells, biology.organism_classification, Cytochalasins, cytochalasin, chemistry, Chemistry (miscellaneous), Cell culture, Yield (chemistry), xylapyrones, cryptic natural product, cytotoxicity, Molecular Medicine, Two-dimensional nuclear magnetic resonance spectroscopy, α-pyrone
Abstract

Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1–5 to six new α-pyrone derivatives, xylapyrones A–F (compounds 6–11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1–3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 μM and compounds 4–11 were found to be inactive, with IC50 values &gt, 100 μM.

Published
2015

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