1. Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection
- Author
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Imesha W. De Silva, John Granger, Guido F. Verbeck, Vijay Singh, Subhayu Nayek, and Jay Reddy
- Subjects
Paper ,ARDS ,Metabolite ,Pneumonia, Viral ,Biology ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,Virus ,Mass Spectrometry ,Analytical Chemistry ,03 medical and health sciences ,chemistry.chemical_compound ,Betacoronavirus ,Metabolomics ,Immune system ,Nasopharynx ,Electrochemistry ,medicine ,Environmental Chemistry ,Humans ,Receptor ,Pandemics ,Spectroscopy ,030304 developmental biology ,Coronavirus ,0303 health sciences ,SARS-CoV-2 ,010401 analytical chemistry ,COVID-19 ,Discriminant Analysis ,medicine.disease ,Lipid Metabolism ,Lipids ,0104 chemical sciences ,chemistry ,Immunology ,Cytokine storm ,Coronavirus Infections ,Biomarkers - Abstract
The SARS-CoV-2 virus is known as the causal agent for the current COVID-19 global pandemic. The majority of COVID-19 patients develop acute respiratory distress syndrome (ARDS), while some experience a cytokine storm effect, which is considered as one of the leading causes of patient mortality. Lipids are known to be involved in the various stages of the lifecycle of a virus functioning as receptors or co-receptors that controls viral propagation inside the host cell. Therefore, lipid-related metabolomics aims to provide insight into the immune response of the novel coronavirus. Our study has focused on determination of the potential metabolomic biomarkers utilizing a Teslin® Substrate in paper spray mass spectrometry (PS-MS) for the development of a rapid detection test within 60 seconds of analysis time. In this study, results were correlated with PCR tests to reflect that the systemic responses of the cells were affected by the COVID-19 virus.
- Published
- 2020