1. Rhizopus -host interplay of disseminated mucormycosis in immunocompetent mice.
- Author
-
Dos Santos AR, Fraga-Silva TF, Almeida DF, Dos Santos RF, Finato AC, Amorim BC, Andrade MI, Soares CT, Lara VS, Almeida NL, de Arruda OS, de Arruda MS, and Venturini J
- Subjects
- Animals, Disease Models, Animal, Disease Progression, Female, Immunity, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Microbial Viability, Mucormycosis pathology, Cytokines immunology, Mucormycosis immunology, Mucormycosis microbiology, Rhizopus oryzae immunology, Th17 Cells immunology
- Abstract
Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae ; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra
-/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae .- Published
- 2020
- Full Text
- View/download PDF