1. Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020.
- Author
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Benameur K, Agarwal A, Auld SC, Butters MP, Webster AS, Ozturk T, Howell JC, Bassit LC, Velasquez A, Schinazi RF, Mullins ME, and Hu WT
- Subjects
- Adult, Brain Diseases cerebrospinal fluid, COVID-19, Coronavirus Infections cerebrospinal fluid, Coronavirus Infections virology, Encephalitis, Viral cerebrospinal fluid, Fatal Outcome, Female, Georgia, Humans, Male, Middle Aged, Pandemics, Pneumonia, Viral cerebrospinal fluid, Pneumonia, Viral virology, SARS-CoV-2, Betacoronavirus, Brain Diseases virology, Coronavirus Infections complications, Cytokines cerebrospinal fluid, Encephalitis, Viral virology, Pneumonia, Viral complications
- Abstract
There are few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection. We describe 3 patients with laboratory-confirmed coronavirus disease who had encephalopathy and encephalitis develop. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM. One patient who died also had increased levels of anti-envelope protein IgM. CSF analysis also showed markedly increased levels of interleukin (IL)-6, IL-8, and IL-10, but severe acute respiratory syndrome coronavirus 2 was not identified in any CSF sample. These changes provide evidence of CSF periinfectious/postinfectious inflammatory changes during coronavirus disease with neurologic complications.
- Published
- 2020
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