1. Ratio between the number of Th1 and Th2 lymphocytes in the peripheral blood and concentration of proinflammatory cytokines in lochia of women with postpartum endometritis.
- Author
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Sukhikh GT, Kasabulatov NM, Van'ko LV, Ordzhonikidze NV, Veryasov VN, and Danelyan SZh
- Subjects
- Blood Cell Count, CD4-Positive T-Lymphocytes metabolism, Female, Humans, Interferon-gamma biosynthesis, Interleukin-1 biosynthesis, Interleukin-4 biosynthesis, Interleukin-6 biosynthesis, Postpartum Period, Tumor Necrosis Factor-alpha biosynthesis, Cytokines metabolism, Endometritis blood, Endometritis metabolism, Inflammation metabolism, Th1 Cells metabolism, Th2 Cells metabolism
- Abstract
We estimated the percentage of CD4+ lymphocytes synthesizing IFN-gamma and IL-4 in the peripheral blood and measured the concentrations of IL-1, IL-6, and TNF-alpha in lochia of patients with postpartum endometritis. T lymphocytes with intracellular IFN-gamma prevailed in women with physiological course of the postpartum period. The number of cells containing IL-4 increased in patients with postpartum endometritis. On days 5-7 after childbirth the concentrations of proinflammatory cytokines IL-1beta and TNF-alpha in lochia of these patients were higher than in healthy postpartum women (by 1.4 and 2.7 times, respectively). The concentrations of cytokines IL-1beta, TNF-alpha, and IL-6 increased most significantly in patients with postpartum endometritis and active viral infection (by 3.4, 4.2, and 1.6 times, respectively).
- Published
- 2005
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