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Your search keyword '"Zwijnenburg, Petra J. G."' showing total 3 results
Start Over Author "Zwijnenburg, Petra J. G." Topic cytokines
3 results on '"Zwijnenburg, Petra J. G."'

1. Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.

Author

Zwijnenburg PJ, van der Poll T, Florquin S, Roord JJ, and van Furth AM

Subjects
Animals, Blood microbiology, Brain immunology, Brain microbiology, Cerebrospinal Fluid microbiology, Interleukin-10 deficiency, Interleukin-10 genetics, Meningitis, Pneumococcal microbiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Streptococcus pneumoniae immunology, Chemokines metabolism, Cytokines metabolism, Gene Expression Regulation, Interleukin-10 immunology, Meningitis, Pneumococcal immunology, Streptococcus pneumoniae pathogenicity
Abstract

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced.

Published
2003
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