1. Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant.
- Author
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Janković M, Ćupić M, Knežević A, Vujić D, Soldatović I, Zečević Ž, Gobeljić B, and Jovanović T
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Cytomegalovirus classification, Cytomegalovirus genetics, Cytomegalovirus metabolism, Female, Genotype, Graft vs Host Disease virology, Humans, Male, Transplantation, Homologous adverse effects, Viral Envelope Proteins metabolism, Young Adult, Cytomegalovirus isolation & purification, Cytomegalovirus Infections virology, Hematopoietic Stem Cell Transplantation adverse effects, Postoperative Complications virology, Viral Envelope Proteins genetics
- Abstract
Clinical significance of the cytomegalovirus (CMV) genotypes in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) has been evaluated mostly in adults. The studies of diverse CMV glycoprotein B (gB) and N (gN) genotype variants in transplanted children and adolescents are lacking. We analyzed the investment of gB and gN genotype variants in the HSCTed children and their relation to clinical complications and disease outcome. The cohort included forty two pediatric recipients of the HSCT. Patients positive for CMV DNAemia (24/42, 57.1%) were genotyped. The gB4 and gN1 genotype variants predominated and were evidenced in 7/18 (38.9%) and 9/19 (47.4%) patients, respectively. The graft-versus-host disease (GvHD) predominated in children with viremia (p < 0.05). Frequencies of the gB and gN genotypes contrasted those reported in recent studies. The GvHD scaled strongly with CMV reactivation whereas viral loads were uncorrelated to medical complications and treatment outcomes., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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