1. DGIdb: mining the druggable genome.
- Author
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Griffith M, Griffith OL, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, Ding L, Walker JR, Larson DE, Dooling DJ, Smith SM, Ley TJ, Mardis ER, and Wilson RK
- Subjects
- Antineoplastic Agents chemistry, Breast Neoplasms drug therapy, Breast Neoplasms genetics, Computational Biology methods, Drug Interactions, Gene Expression Regulation drug effects, Genetic Variation, Genome, Genomics methods, Humans, Lung Neoplasms drug therapy, Lung Neoplasms genetics, Mutation, Software, Technology, Pharmaceutical methods, Data Mining methods, Databases, Genetic, Drug Discovery methods
- Abstract
The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/.
- Published
- 2013
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