1. Association between XRCC3 Thr241Met polymorphism and risk of gynecological malignancies: A meta-analysis.
- Author
-
Yu, Xiangyuan, Wang, Qianqian, He, Gaofeng, and Yu, Hongping
- Subjects
- *
META-analysis , *ODDS ratio , *SAMPLE size (Statistics) , *CONFIDENCE intervals , *DATABASE searching , *CAUCASIAN race - Abstract
• We have 15 publications with 5,740 cases and 9,931 controls were included in this meta-analysis. • We found that the T allele of the X -ray cross-complementing group 3 protein (XRCC3) Thr241Met polymorphism was significantly associated with an increased risk to gynecological malignancies (GM) in Asians but not in Caucasians. • Our findings indicate that the effect of the XRCC3 Thr241Met polymorphism on the risk of GM is ethnically different and this SNP has its obvious effect on the development of GM in Asians. • There was no meta-analysis about the association between XRCC3 Thr241Met polymorphism and risk of GM until now. Studies have investigated the relationship between the X -ray cross- complementing group 3 (XRCC3) Thr241Met polymorphism and the risk of gynecological malignancies (GM) with the contradictory conclusions. Here, a meta-analysis was performed to provide clear picture of the association between Thr241Met and GM risk. The Pubmed and Chinese National Knowledge Infrastructure (CNKI) databases were searched for published eligible studies. The pooled odds ratios (OR) with their corresponding 95% confidence interval (CI) was used to assessed the strength of association. Totally, 15 publications with 5,740 cases and 9,931 controls were included. In the overall analysis, the results of meta-analysis showed no significant association between the Thr241Met and the risk of GM. However, in the Asians subgroup, significant increased risks were found in the comparisons of TT/CT+TT vs. CC(TT vs. CC: OR=3.25, 95% CI=1.47–7.18; CT+TT vs. CC: OR=1.51, 95%CI=1.10–2.09) in Asians; additionally, stratified analysis by cancer type in Asians, significantly increased risks was found in cervical carcinoma (CT vs. CC: OR=1.50, 95%CI=1.04–2.14; TT vs. CC: OR=3.14, 95%CI=1.38–7.14; CT+TT vs. CC: OR=1.64, 95% CI=1.17–2.31). It suggests that the risk of GM might be significantly increased by the XRCC3 Thr241Met polymorphism according to ethnicity and cancer types. Further studies with larger sample size in different ethnic populations and different sites of GM are needed to verify the findings. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF