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Your search keyword '"Kubota, Kiyoshi"' showing total 8 results
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8 results on '"Kubota, Kiyoshi"'

1. Brief Report: Databases in the Asia-Pacific Region: The Potential for a Distributed Network Approach.

Author

Lai EC, Man KK, Chaiyakunapruk N, Cheng CL, Chien HC, Chui CS, Dilokthornsakul P, Hardy NC, Hsieh CY, Hsu CY, Kubota K, Lin TC, Liu Y, Park BJ, Pratt N, Roughead EE, Shin JY, Watcharathanakij S, Wen J, Wong IC, Yang YH, Zhang Y, and Setoguchi S

Subjects
China, Clinical Coding, Computer Communication Networks, Feasibility Studies, Health Expenditures, Hong Kong, Humans, Japan, Neoplasms, Pharmacoepidemiology, Republic of Korea, Singapore, Stroke, Taiwan, Thailand, Databases, Factual, Electronic Health Records, Information Dissemination methods, Insurance, Health, Registries
Abstract

Background: This study describes the availability and characteristics of databases in Asian-Pacific countries and assesses the feasibility of a distributed network approach in the region., Methods: A web-based survey was conducted among investigators using healthcare databases in the Asia-Pacific countries. Potential survey participants were identified through the Asian Pharmacoepidemiology Network., Results: Investigators from a total of 11 databases participated in the survey. Database sources included four nationwide claims databases from Japan, South Korea, and Taiwan; two nationwide electronic health records from Hong Kong and Singapore; a regional electronic health record from western China; two electronic health records from Thailand; and cancer and stroke registries from Taiwan., Conclusions: We identified 11 databases with capabilities for distributed network approaches. Many country-specific coding systems and terminologies have been already converted to international coding systems. The harmonization of health expenditure data is a major obstacle for future investigations attempting to evaluate issues related to medical costs.

Published
2015
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2. Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries.

Author

Pratt N, Chan EW, Choi NK, Kimura M, Kimura T, Kubota K, Lai EC, Man KK, Ooba N, Park BJ, Sato T, Shin JY, Wong IC, Kao Yang YH, and Roughead EE

Subjects
Amiodarone adverse effects, Analysis of Variance, Asia epidemiology, Australia epidemiology, Chi-Square Distribution, Drug-Related Side Effects and Adverse Reactions diagnosis, Gout chemically induced, Gout epidemiology, Humans, Hypothyroidism chemically induced, Hypothyroidism epidemiology, Odds Ratio, Pharmacoepidemiology, Pharmacovigilance, Reproducibility of Results, Risk Assessment, Risk Factors, Thyroxine adverse effects, Time Factors, Adverse Drug Reaction Reporting Systems standards, Adverse Drug Reaction Reporting Systems trends, Databases, Factual standards, Databases, Factual trends, Drug Prescriptions standards, Drug-Related Side Effects and Adverse Reactions epidemiology
Abstract

Background: Prescription sequence symmetry analysis (PSSA) is a signal detection method for adverse drug events. Its capacity to consistently detect adverse drug events across different settings has not been tested. We aimed to determine the consistency of PSSA results for detecting positive and negative control adverse drug events across different settings., Methods: Using a distributed network model, we analyzed prescription dispensing data using PSSA in Australia, Hong Kong, Japan, Korea, and Taiwan. Positive control was amiodarone and thyroxine, as a marker of amiodarone-induced hypothyroidism, a known adverse event with a clear temporal relationship to amiodarone initiation. Negative controls were amiodarone and allopurinol, as a marker of amiodarone-induced gout and thyroxine and allopurinol, as a marker of thyroxine-induced gout. Gout is not recorded as an adverse event in product information for either medicine. Adjusted sequence ratios (ASR) were calculated for each country. Pooled estimates were obtained by using the generic inverse variance method., Results: A positive association was identified between amiodarone and thyroxine in all settings with a pooled ASR 2.63 (95% confidence interval (CI) 1.47-4.72). Temporal analysis showed the effect occurred within the first few weeks of treatment. No significant associations were found for the negative controls in any setting; pooled ASR were 0.76 (95%CI 0.62-0.93) and 0.98 (95%CI 0.85-1.12) for amiodarone-allopurinol and thyroxine-allopurinol, respectively., Conclusion: Despite different health settings, different populations, and different patterns of medicine utilization, PSSA gave consistent estimates across countries for a well-known positive association and two negative control adverse events., (© 2015 The Authors Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd.)

Published
2015
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3. The Asian Pharmacoepidemiology Network (AsPEN): promoting multi-national collaboration for pharmacoepidemiologic research in Asia.

Author

Andersen M, Bergman U, Choi NK, Gerhard T, Huang C, Jalbert J, Kimura M, Kimura T, Kubota K, Lai EC, Ooba N, Park BJ, Pratt N, Roughead EE, Sato T, Setoguchi S, Shin JY, Sundström A, and Yang YH

Subjects
Adverse Drug Reaction Reporting Systems, Asia epidemiology, Data Mining, Drug Prescriptions, Drug Utilization Review, Drug-Related Side Effects and Adverse Reactions epidemiology, Forecasting, Humans, Pharmacovigilance, Cooperative Behavior, Databases, Factual statistics & numerical data, Databases, Factual trends, International Cooperation, Pharmacoepidemiology methods
Published
2013
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4. Claims-based definition of death in Japanese claims database: validity and implications.

Author

Ooba N, Setoguchi S, Ando T, Sato T, Yamaguchi T, Mochizuki M, and Kubota K

Subjects
Adult, Aged, Female, Humans, Japan, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Young Adult, Databases, Factual, Death, Insurance Claim Review standards
Abstract

Background: For the pending National Claims Database in Japan, researchers will not have access to death information in the enrollment files. We developed and evaluated a claims-based definition of death., Methodology/principal Findings: We used healthcare claims and enrollment data between January 2005 and August 2009 for 195,193 beneficiaries aged 20 to 74 in 3 private health insurance unions. We developed claims-based definitions of death using discharge or disease status and Charlson comorbidity index (CCI). We calculated sensitivity, specificity and positive predictive values (PPVs) using the enrollment data as a gold standard in the overall population and subgroups divided by demographic and other factors. We also assessed bias and precision in two example studies where an outcome was death. The definition based on the combination of discharge/disease status and CCI provided moderate sensitivity (around 60%) and high specificity (99.99%) and high PPVs (94.8%). In most subgroups, sensitivity of the preferred definition was also around 60% but varied from 28 to 91%. In an example study comparing death rates between two anticancer drug classes, the claims-based definition provided valid and precise hazard ratios (HRs). In another example study comparing two classes of anti-depressants, the HR with the claims-based definition was biased and had lower precision than that with the gold standard definition., Conclusions/significance: The claims-based definitions of death developed in this study had high specificity and PPVs while sensitivity was around 60%. The definitions will be useful in future studies when used with attention to the possible fluctuation of sensitivity in some subpopulations.

Published
2013
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5. Comparative safety of NSAIDs for gastrointestinal events in Asia-Pacific populations: a multi-database, international cohort study

Author

Kenneth K.C. Man, Byung Joo Park, Soko Setoguchi, Edward Chia Cheng Lai, Ju-Young Shin, Kiyoshi Kubota, Elizabeth E. Roughead, Yea Huei Kao Yang, Ian C. K. Wong, Nicole L. Pratt, Lai, Edward Chia-Cheng, Shin, Ju-Young, Kubota, Kiyoshi, Man, Kenneth KC, Park, Byung Joo, Pratt, Nicole, Roughead, Elizabeth E, Wong, Ian CK, Kao Yang, Yea-Huei, and Setoguchi, Soko

Subjects
Male, Diclofenac, pharmacoepidemiology, Databases, Factual, Mefenamic acid, Gastrointestinal Diseases, Epidemiology, Taiwan, computer.software_genre, Lower risk, 030226 pharmacology & pharmacy, anti-inflammatory agents, Mefenamic Acid, 03 medical and health sciences, 0302 clinical medicine, Japan, Republic of Korea, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Aged, Aged, 80 and over, Phenylpropionates, Database, business.industry, Incidence, Incidence (epidemiology), Anti-Inflammatory Agents, Non-Steroidal, Hazard ratio, Australia, Loxoprofen, non-steriodal, Discontinuation, Hospitalization, Celecoxib, Hong Kong, Female, business, computer, Follow-Up Studies, medicine.drug, Cohort study
Abstract

Purpose: The safety of nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used in Asia-Pacific countries has had limited study. We assessed the risk of hospitalization for gastrointestinal events with loxoprofen and mefenamic acid compared with other NSAIDs in Asia-Pacific populations. Methods: We conducted a cohort study using a distributed network with a common data model in Australia, Hong Kong, Japan, Korea, and Taiwan. We included patients who initiated diclofenac, loxoprofen, mefenamic acid, or celecoxib and followed them until their first gastrointestinal hospitalization, switch or discontinuation of medication, disenrollment, or end of database coverage. We used Cox proportional hazards models to assess hospitalization risk. Results: We identified 9879 patients in Japan, 70 492 in Taiwan, 263 741 in Korea, and 246 in Hong Kong who initiated an NSAID, and 44 013 patients in Australia, a predominantly Caucasian population. The incidence of gastrointestinal hospitalization was 25.6 per 1000 person-years in Japan, 32.8 in Taiwan, 11.5 in Korea, 484.5 in Hong Kong, and 35.6 in Australia. Compared with diclofenac, the risk of gastrointestinal events with loxoprofen was significantly lower in Korea (hazards ratio, 0.37; 95% CI, 0.25-0.54) but not in Japan (1.65; 95% CI, 0.47-5.78). The risk of gastrointestinal events with mefenamic acid was significantly lower in Taiwan (0.45; 95% CI, 0.26-0.78) and Korea (0.11; 95% CI, 0.05-0.27) but not Hong Kong (2.16; 95% CI, 0.28-16.87), compared with diclofenac. Conclusions: Compared with diclofenac, loxoprofen was associated with a lower risk of gastrointestinal hospitalizations in Korea and mefenamic acid with a lower risk in Taiwan and Korea Refereed/Peer-reviewed

Published
2018

6. Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries

Author

Ju-Young Shin, Kiyoshi Kubota, Byung Joo Park, Michio Kimura, Kenneth K.C. Man, Esther W. Chan, Nobuhiro Ooba, Edward Chia Cheng Lai, Yea Huei Kao Yang, Elizabeth E. Roughead, Nam Kyong Choi, Tomomi Kimura, Tsugumichi Sato, Nicole L. Pratt, Ian C. K. Wong, Pratt, Nicole, Chan, Esther W, Choi, Nam-Kyong, Kimura, Michio, Kimura, Tomomi, Kubota, Kiyoshi, Lai, Edward Chia-Cheng, Man, Kenneth KC, Ooba, Nobuhiro, Park, Byung-Joo, Sato, Tsugumichi, Shin, Ju-Young, Wong, Ian CK, Kao, Yang Yea-Huei, and Roughead, Elizabeth E

Subjects
medicine.medical_specialty, Asia, Time Factors, pharmacoepidemiology, Databases, Factual, Drug-Related Side Effects and Adverse Reactions, Gout, Epidemiology, Amiodarone, Drug Prescriptions, Risk Assessment, prescription symmetry analysis, Pharmacovigilance, Hypothyroidism, Risk Factors, Internal medicine, Original Reports, Odds Ratio, medicine, Adverse Drug Reaction Reporting Systems, Humans, hyperthyroidism, Pharmacology (medical), Medical prescription, Adverse effect, amiodarone, Analysis of Variance, Chi-Square Distribution, business.industry, Australia, Reproducibility of Results, Odds ratio, Pharmacoepidemiology, Confidence interval, Surgery, Thyroxine, pharmacovigilance, Risk assessment, business, Chi-squared distribution
Abstract

Background Prescription sequence symmetry analysis (PSSA) is a signal detection method for adverse drug events. Its capacity to consistently detect adverse drug events across different settings has not been tested. We aimed to determine the consistency of PSSA results for detecting positive and negative control adverse drug events across different settings. Methods Using a distributed network model, we analyzed prescription dispensing data using PSSA in Australia, Hong Kong, Japan, Korea, and Taiwan. Positive control was amiodarone and thyroxine, as a marker of amiodarone-induced hypothyroidism, a known adverse event with a clear temporal relationship to amiodarone initiation. Negative controls were amiodarone and allopurinol, as a marker of amiodarone-induced gout and thyroxine and allopurinol, as a marker of thyroxine-induced gout. Gout is not recorded as an adverse event in product information for either medicine. Adjusted sequence ratios (ASR) were calculated for each country. Pooled estimates were obtained by using the generic inverse variance method. Results A positive association was identified between amiodarone and thyroxine in all settings with a pooled ASR 2.63 (95% confidence interval (CI) 1.47–4.72). Temporal analysis showed the effect occurred within the first few weeks of treatment. No significant associations were found for the negative controls in any setting; pooled ASR were 0.76 (95%CI 0.62–0.93) and 0.98 (95%CI 0.85–1.12) for amiodaroneallopurinol and thyroxine-allopurinol, respectively. Conclusion Despite different health settings, different populations, and different patterns of medicine utilization, PSSA gave consistent estimates across countries for a well-known positive association and two negative control adverse events. © 2015 The Authors Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd. key words—prescription symmetry analysis; pharmacovigilance; amiodarone; hyperthyroidism; pharmacoepidemiology

Published
2015

7. Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis

Author

Jenna Griffiths, Nicole L. Pratt, Tsugumichi Sato, Tong Tong Wang, Esther W. Chan, Byung Joo Park, Tomomi Kimura, Michio Kimura, Xue Mei Jin, Tuan Anh Nguyen, Yea Huei Kao Yang, Edward Chia Cheng Lai, Ian C. K. Wong, Ju-Young Shin, Nobuhiro Ooba, Nam Kyong Choi, Joongyub Lee, Kenneth K.C. Man, Elizabeth E. Roughead, Kiyoshi Kubota, Roughead, Elizabeth E, Chan, Esther W, Choi, Nam-Kyong, Griffiths, Jenna, Jin, Xui-Mei, Lee, Joongyub, Kimura, Michio, Kimura, Tomomi, Kubota, Kiyoshi, Lai, Edward Chia-Cheng, Man, Kenneth KC, Nguyen, Tuan Anh, Ooba, Nobuhiro, Park, Byung-Joo, Sato, Tsugumichi, Shin, Ju-Young, Wang, TongTong, Wong, Ian CK, Yang, Yea-Huei Kao, and Pratt, Nicole L

Subjects
medicine.medical_specialty, Asia, genetic structures, Databases, Factual, Population, sequence symmetry analysis, adverse event, Total population, 03 medical and health sciences, 0302 clinical medicine, Vancomycin, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, education, National data, Oral vancomycin, Sequence (medicine), Aged, education.field_of_study, business.industry, Clostridioides difficile, Proton Pump Inhibitors, General Medicine, Clostridium difficile, clostridium difficile, Clostridium difficile infections, Surgery, Anti-Bacterial Agents, Clostridium Infections, 030211 gastroenterology & hepatology, proton pump inhibitors, business, Demography, Multi country
Abstract

Objective: To determine the association between incident proton pump inhibitor (PPI) use and Clostridium difficile infections across multiple countries Method: National data covering the total population in Australia and Korea, the Canadian population over 65 years and a 3 million person random sample data set from Taiwan were assessed, as were data from a worker insurance population and a hospital inpatient/outpatient population in Japan. Sequence symmetry analysis was used to assess the association with oral vancomycin dispensing as the outcome of interest. Results: 54,957 patients were included. Positive associations were observed in Australia; adjusted sequence ratio (ASR) 2.48 (95% CI 1.90, 3.12), Korea ASR 2.15 (95%CI 2.11, 2.19), Canada ASR 1.45 (95% CI 1.16, 1.79), Japan hospital dataset ASR 3.21 (95%CI 2.12, 4.55) and Japan worker insurance dataset ASR 5.40 (95% CI 2.73, 8.75). The pooled result was ASR 2.40 (95%CI 1.88, 3.05) and 3.16 (95%CI 1.95, 5.10) when limited to Japan, Korean and Taiwan. Results did not vary by individual PPI. The temporal analysis showed effects within the first two weeks of PPI initiation. Conclusion: Our study confirms the association between PPI initiation and C. difficile infections across countries in the Asia-Pacific region. Refereed/Peer-reviewed

Published
2016

8. Variation in association between thiazolidinediones and heart failure across ethnic groups: retrospective analysis of large healthcare claims databases in six countries

Author

Elizabeth E. Roughead, Kiyoshi Kubota, Jenna Griffiths, Nam Kyong Choi, Tong Tong Wang, Tuan Anh Nguyen, Edward Chia Cheng Lai, Tsugumichi Sato, Nicole L. Pratt, Tomomi Kimura, Nobuhiro Ooba, Yea Huei Kao Yang, Kenneth K.C. Man, Ian C. K. Wong, Ju-Young Shin, Esther W. Chan, Michio Kimura, Byung Joo Park, Roughead, Elizabeth E, Chan, Esther W, Choi, Nam-Kyong, Kimura, Michio, Kimura, Tomomi, Kubota, Kiyoshi, Lai, Edward Chia-Cheng, Man, Kenneth KC, Nguyen, Tuan Anh, Ooba, Nobuhiro, Park, Byung-Joo, Sato, Tsugumichi, Shin, Ju-Young, Wang, TongTong, Griffiths, Jenna, Wong, Ian CK, Yang, Yea-Huei Kao, and Pratt, Nicole

Subjects
medicine.medical_specialty, drug safety, Databases, Factual, Ethnic group, Pharmacology, Toxicology, ethnic groups, Rosiglitazone, Furosemide, Internal medicine, Health care, heart failture, medicine, Retrospective analysis, Ethnicity, Edema, Humans, Pharmacology (medical), Claims database, Original Research Article, thiazolidinediones, Retrospective Studies, Heart Failure, Polymorphism, Genetic, Pioglitazone, business.industry, Retrospective cohort study, medicine.disease, 3. Good health, Hospitalization, Heart failure, Thiazolidinediones, pharmacology, business, medicine.drug, toxicology
Abstract

Introduction: The prevalence of polymorphisms among the metabolising enzymes and pharmacodynamic receptors relevant for the thiazolidinediones differs by ethnic group, a factor that may modify risk of adverse drug events. Objective: The aim of the study was to determine if the risk of oedema or heart failure associated with the thiazolidinediones varies in populations in Australia, Canada, Hong Kong, Japan, Korea and Taiwan. Methods: Sequence symmetry analyses were undertaken to investigate the risk of peripheral oedema, as measured by incident furosemide dispensing, and risk of hospitalisations for heart failure. Results were pooled, with Australia and Canada representing predominantly Caucasian population and all other countries contributing to Asian population estimates. Results: Pooled estimates of risk for furosemide initiation in the Caucasian populations were significantly increased for pioglitazone [adjusted sequence ratio (ASR) 1.47; 95 % confidence interval (CI) 1.14-1.91] and rosiglitazone (ASR 1.65; 95 % CI 1.58-1.72), while in the Asian populations, the pooled risk estimates were lower (ASR 1.11; 95 % CI 0.93-1.32 and ASR 1.21; 95 % CI 1.01-1.45 for pioglitazone and rosiglitazone, respectively). Results for hospitalisation for heart failure showed a similar trend, with elevated risk in the Australian data (ASR 1.88; 95 % CI 1.01-3.5 and ASR 1.25; 95 % CI 0.76-2.05 for pioglitazone and rosiglitazone, respectively), while no increased risk was found in the pooled results for the Asian populations. Conclusion: The risk of both oedema and heart failure with thiazolidinediones was higher in predominantly Caucasian countries than in the Asian countries assessed. Assessment of adverse events by ethnicity may support safer medicine use. Refereed/Peer-reviewed

Published
2015

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