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Objective: Combinatorial targeted therapy has been suggested as a powerful approach to overcome drug resistance and also might lead to a dose reduction of the single drugs. Based on a previous drug screening in meningioma cell lines, we identified OTSSP167 (MELK inhibitor) and Panobinostat (HDAC inhibitor) [for full text, please go to the a.m. URL]

Objective: Isocitrate Dehydrogenase-mutated (IDHmut) and wildtype (IDHwt) gliomas are regarded as separate tumor entities with the need for accordingly adjusted therapies. IDHmut tumors have a better prognosis than the wildtype. Nevertheless they are still not curable since there is no effective drug [for full text, please go to the a.m. URL]

Objective: Tumor-organoids (TO) are mini-tumors generated from tumor tissue preserving its genotype and phenotype by maintaining the cellular heterogeneity and important components of the tumor microenvironment. We recently developed a protocol to reliably establish TOs from meningioma (MGM) in large [for full text, please go to the a.m. URL]

Objective: The management of aggressive meningiomas remains challenging due to limited treatment options beside surgical removal and radiotherapy. High recurrence rates and lack of effective chemotherapies may be reasons for unfavorable prognosis of these patients. Consequently, there is an urgent need[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Tumour-associated macrophages (TAMs) play an emerging role in tumour progression by creating an immunosuppressive tumour microenvironment. Therefore, we investigated TAM numbers and their activation (M1/2) in primary (p‑) and recurrent (r‑) meningiomas and evaluated their[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Cancer-derived organoids (CDOs) are novel, complex three-dimensional ex vivo tissue cultures that accurately reflect genotype and phenotype of the original tumor with preserved cellular heterogeneity and structural architecture. They offer a new and exciting platform for studying cancer biology[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The discovery of the Isocitrate Dehydrogenase (IDH) mutation in glioma has led to a paradigm shift on how we see glioma biology. While it is clear that IDH mutated (IDHmut) and wildtype (IDHwt) tumors have to be viewed as separate entities, the underlying biological differences are still [for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Treatment of aggressive meningiomas is still challenging for a couple of reasons, including high rate of recurrence of higher-grade meningiomas, impossible total resection and a lack of effective chemotherapies. To address this urgent need for more successful treatments of aggressive[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Intraventricular meningiomas (IVMs) are rare tumors which only account for 0.5–3% of all meningiomas (MGMs) and up to 14% of all intraventricular tumors. Although there is increasing knowledge about the clinical and molecular features of MGMs per se, little is known about[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: The kinesin superfamily (KIF) members are highly conserved motor proteins, which are classified into 14 families. Kinesins play an important role in cellular functions including transport of vesicles and mitosis. Overexpression of the motor protein KIF11 can induce premature sister chromatid[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: We have recently reported that spatial relationship of primary glioblastomas (pGBMs) to the subventricular zone (SVZ), the predominant neurogenic region of the adult brain, is associated with inferior patient survival and significantly increased protein expression of neural stem cell (NSC)[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Despite unfavorable diagnosis, 3–5% of glioblastoma patients show long-term survival of 36 months or longer after diagnosis. Recent publications indicate that this survival benefit bases on altered gene expression. Epigenetic modifications, e.g. DNA methylation are known to be[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: In many cell types retinoic acid (RA) leads to differentiation and growth inhibition. Due to aberrant distribution of the RA binding proteins FABP5 and CRABP2 breast cancer cells do not differentiate but instead enter a prosurvival pathway after RA exposure. Similarly, glioblastoma stem-like[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Einleitung: Im Deutschen Ärzteblatt wurde im Sommer 2008 in einer Übersichtsarbeit eine Überlebenszeit von „weniger als 12 Monaten für die meisten CUP-Patienten“ angegeben; laut großen retrospektiven Studien liege das mediane Überleben bei 3 bis 6 Monaten,[for full text, please go to the a.m. URL], 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie