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Literature suggests that using behavioral theory to inform research can improve the efficiency of knowledge translation (KT) interventions and guide their implementation. Therefore, we conducted a scoping review of the use of behavioral theories, models, and frameworks in the published literature to guide the implementation of evidence-informed decision-making (EIDM) interventions. We used a thorough two-step search strategy to retrieve articles fulfilling the inclusion criteria published through August 2022. Two reviewers initially screened the articles individually, followed by two reviewers who independently reviewed the articles' full text. We critically appraised 90 full-text articles from 3172 retrieved articles based on inclusion and exclusion criteria. We finally included 19 articles for qualitative synthesis, which included the elements of KT intervention, underlying theories/models of behavior change and the purpose of their use, and facilitators and barriers to KT intervention. Our results showed that no study explicitly focused on EIDM and simultaneously utilized behavioral theories to design or inform the implementation of an intervention. Furthermore, we found that the Theoretical Domain Framework, the Theory of Planned Behavior, the Behavioral Change Wheel, and the Capability, Opportunity, and Motivation Behavior Model were most frequently used to guide the implementation of KT interventions. Our study identified a vital gap that must be filled in relation to EIDM research on intervention implementation. Thus, our findings can support and enrich those planning to launch an EIDM initiative in terms of selecting the base theory/model/framework, anticipating the facilitators and barriers to implementation, and determining the most appropriate intervention component. [ABSTRACT FROM AUTHOR]

Highlights • Contextual factors of patients' everyday lives are important in treatment decision making. • Often contextual factors are not discussed when making treatment decisions. • Clinicians should understand and address the contextual factors when discussing treatments. Abstract Background Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system that mainly affects young adults. While there is no cure for MS, disease modifying treatments (DMTs) reduce the relapse rate and partial accrual of disability. More effective DMTs may have higher risks including life-threatening infections or secondary autoimmunity. The complexity and novelty of available treatments cause challenges for clinicians when prescribing treatments and for people with MS (PwMS) when deciding what trade-offs they are willing and ready to make. Objective To explore the experience of people with relapsing remitting MS (PwRRMS) and their perspectives in choosing treatments. Methods Critical interpretive synthesis was employed to review and synthesis the published literature. Eighty-three publications were selected in a multi-step systematic process. Results Findings are presented in four interrelated areas: the influence of the clinical evidence-base in decision making; the meaning of DMT efficacy for PwRRMS; the influence of models of decision-making and information acquisition practices in PwRRMS; and the importance of psychosocial dimensions in DMT decision making. Synthesis of the findings revealed that alongside medical and individual reasoning, contextual circumstances play an important role in making treatment decisions. Conclusion This review identifies and explains the importance of diverse contextual circumstances (clinical, social, psychological) that are important for PwRRMS when making treatment decisions. The findings demonstrate the importance of eliciting, understanding and addressing such contextual factors. [ABSTRACT FROM AUTHOR]

In a healthcare environment that is trying to achieve better clinical outcomes and patient satisfaction, shared decision-making is a well-established concept that is gaining more interest. Multiple sclerosis is a preference-sensitive condition and provides the opportunity to implement decision aids at various decision points in the disease process. Literature about patient education and outcomes of shared decision aids in multiple sclerosis has been growing over the last decade. In this topical review, we present an overview of the current literature on shared decision-making in multiple sclerosis. While limitations to the generalizability and applicability of decision aids exist, there is evidence that decision aids and shared decision-making can be valuable tools in the clinical care of multiple sclerosis patients. [ABSTRACT FROM AUTHOR]