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A new family of codes, called clustering-correcting codes, is presented in this paper. This family of codes is motivated by the special structure of the data that is stored in DNA-based storage systems. The data stored in these systems has the form of unordered sequences, also called strands, and every strand is synthesized thousands to millions of times, where some of these copies are read back during sequencing. Due to the unordered structure of the strands, an important task in the decoding process is to place them in their correct order. This is usually accomplished by allocating part of the strand for an index. However, in the presence of errors in the index field, important information on the order of the strands may be lost. Clustering-correcting codes ensure that if the distance between the index fields of two strands is small, their data fields have large distance. It is shown how this property enables to place the strands together in their correct clusters even in the presence of errors. We present lower and upper bounds on the size of clustering-correcting codes and an explicit construction of these codes which uses only a single symbol of redundancy. The results are first presented for the Hamming metric and are then extended for the edit distance. [ABSTRACT FROM AUTHOR]

The sequence reconstruction problem corresponds to the model in which a sequence from some code is transmitted over several noisy channels that produce distinct outputs. Then, the channels’ outputs, received by the decoder, are used to recover the transmitted sequence, and the main problem under this paradigm is to calculate the minimum number of channels that enables unique reconstruction of the transmitted word. This problem is equivalent to finding the size of the largest intersection of channels’ outputs sets received after transmitting distinct codewords. Motivated by the error behavior observed in DNA storage systems, the present work extends the study of the reconstruction model to the case in which a binary word is transmitted over channels prone to substitutions, insertions, and deletions. Furthermore, we also study the size of the error balls generated by either one deletion and at most a fixed number of substitutions or one insertion and at most one substitution in a binary word. For the case of only substitutions, we present a decoder of optimal complexity, which improves upon a recent construction of such a decoder. Lastly, a simplification of that decoder is studied in case there are more channels than the minimum required number. [ABSTRACT FROM AUTHOR]

In this paper we consider the problem of encoding data into repeat-free sequences in which sequences are imposed to contain any k-tuple at most once (for predefined k). First, the capacity of the repeat-free constraint are calculated. Then, an efficient algorithm, which uses two bits of redundancy, is presented to encode length-n sequences for k = 2 + 2 log (n). This algorithm is then improved to support any value of k of the form k = a log (n), for 1 < a, while its redundancy is o(n). We also calculate the capacity of repeat-free sequences when combined with local constraints which are given by a constrained system, and the capacity of multi-dimensional repeat-free codes. [ABSTRACT FROM AUTHOR]

This paper studies reconstruction of strings based upon their substrings spectrum. Under this paradigm, it is assumed that all substrings of some fixed length are received and the goal is to reconstruct the string. While many existing works assumed that substrings are received error free, we follow in this paper the noisy setup of this problem that was first studied by Gabrys and Milenkovic. The goal of this study is twofold. First we study the setup in which not all substrings in the multispectrum are received, and then we focus on the case where the read substrings are not error free. In each case we provide specific code constructions of strings that their reconstruction is guaranteed even in the presence of failure in either model. We present efficient encoding and decoding maps and analyze the cardinality of the code constructions, while studying the cases where the rates of our codes approach 1. [ABSTRACT FROM AUTHOR]

Mutually uncorrelated (MU) codes are a class of codes in which no proper prefix of one codeword is a suffix of another codeword. These codes were originally studied for synchronization purposes and recently, Yazdi et al. showed their applicability to enable random access in DNA storage. In this paper,we follow the research of Yazdi et al. and study MU codes along with their extensions to correct errors and balanced codes. We first review a well-known construction of MU codes and study the asymptotic behavior of its cardinality. This task is accomplished by studying a special class of run-length limited codes that impose the longest run of zeros to be at most some function of the codewords length. We also present an efficient algorithm for this class of constrained codes and show how to use this analysis for MU codes. Next, we extend the results on the run-length limited codes in order to study $(d_{h},d_{m})$ -MU codes that impose a minimum Hamming distance of $d_{h}$ between different codewords and $d_{m}$ between prefixes and suffixes. In particular, we show an efficient construction of these codes with nearly optimal redundancy. We also provide similar results for the edit distance and balanced MU codes. Last, we draw connections to the problems of comma-free and prefix synchronized codes. [ABSTRACT FROM AUTHOR]

Motivated by the error behavior in the DNA storage channel, in this paper, we extend the previously studied sequence reconstruction problem by Levenshtein. The reconstruction problem studies the model in which the information is read through multiple noisy channels, and the decoder, which receives all channel estimations, is required to decode the information. For the combinatorial setup, the assumption is that all the channels cause at most some t errors. Levenshtein considered the case in which all the channels have the same behavior, and we generalize this model and assume that the channels are not identical. Thus, different channels may cause different maximum numbers of errors. For example, we assume that there are N channels, which cause at most t1 or t2 errors, where t1 < t2, and the number of channels with at most t1 errors is at least [pN], for some fixed 0 < p < 1. If the information codeword belongs to a code with minimum distance d, the problem is then to find the minimum number of channels that guarantees successful decoding in the worst case. A different problem we study in this paper is where the number of channels is fixed, and the question is finding the minimum distance d that provides exact reconstruction. We study these problems and show how to apply them for the cases of substitutions and transpositions. [ABSTRACT FROM AUTHOR]

Motivated by applications in DNA-based storage, we introduce the new problem of code design in the Damerau metric. The Damerau metric is a generalization of the Levenshtein distance which, in addition to deletions, insertions, and substitution errors also accounts for adjacent transposition edits. We first provide constructions for codes that may correct either a single deletion or a single adjacent transposition and then proceed to extend these results to codes that can simultaneously correct a single deletion and multiple adjacent transpositions. We conclude with constructions for joint block deletion and adjacent block transposition error-correcting codes.11

Parts of the results were presented at the International Symposium on Information Theory in Barcelona, 2016.