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Childhood demyelinative diseases classification (DDC) with brain magnetic resonance imaging (MRI) is crucial to clinical diagnosis. But few attentions have been paid to DDC in the past. How to accurately differentiate pediatric-onset neuromyelitis optica spectrum disorder (NMOSD) from acute disseminated encephalomyelitis (ADEM) based on MRI is challenging in DDC. In this paper, a novel architecture M-DDC based on joint U-Net segmentation network and deep convolutional network is developed. The U-Net segmentation can provide pixel-level structure information, that helps the lesion areas location and size estimation. The classification branch in DDC can detect the regions of interest inside MRIs, including the white matter regions where lesions appear. The performance of the proposed method is evaluated on MRIs of 201 subjects recorded from the Children's Hospital of Zhejiang University School of Medicine. The comparisons show that the proposed DDC achieves the highest accuracy of 99.19% and dice of 71.1% for ADEM and NMOSD classification and segmentation, respectively. [ABSTRACT FROM AUTHOR]

Heart sound classification plays a vital role in the early detection of cardiovascular disorders, especially for small primary health care clinics. Despite that much progress has been made for heart sound classification in recent years, most of them are based on conventional segmented features and shallow structure based classifiers. These conventional acoustic representation and classification methods may be insufficient in characterizing heart sound, and generally suffer from a degraded performance due to the complicated and changeable cardiac acoustic environment. In this paper, we propose a new heart sound classification method based on improved Mel-frequency cepstrum coefficient (MFCC) features and convolutional recurrent neural networks. The Mel-frequency cepstrums are firstly calculated without dividing the heart sound signal. A new improved feature extraction scheme based on MFCC is proposed to elaborate the dynamic characteristics among consecutive heart sound signals. Finally, the MFCC-based features are fed to a deep convolutional and recurrent neural network (CRNN) for feature learning and later classification task. The proposed deep learning framework can take advantage of the encoded local characteristics extracted from the convolutional neural network (CNN) and the long-term dependencies captured by the recurrent neural network (RNN). Comprehensive studies on the performance of different network parameters and different network connection strategies are presented in this paper. Performance comparisons with state-of-the-art algorithms are given for discussions. Experiments show that, for the two-class classification problem (pathological or non-pathological), a classification accuracy of 98% has been achieved on the 2016 PhysioNet/CinC Challenge database. • We propose a new MFCC-based heart sound classification method. • A new improved MFCC feature extraction scheme is developed. • CNN and RNN are combined for heart sound classification. • We show promising performance on benchmark PCG databases. [ABSTRACT FROM AUTHOR]

Automatic detection of retinal diseases based on deep learning technology and Ultra-widefield (UWF) images plays an important role in clinical practices in recent years. However, due to small lesions and limited data samples, it is not easy to train a detection-accurate model with strong generalization ability. In this paper, we propose a lesion attention conditional generative adversarial network (LAC-GAN) to synthesize retinal images with realistic lesion details to improve the training of the disease detection model. Specifically, the generator takes the vessel mask and class label as the conditional inputs, and processes the random Gaussian noise by a series of residual block to generate the synthetic images. To focus on pathological information, we propose a lesion feature attention mechanism based on random forest (RF) method, which constructs its reverse activation network to activate the lesion features. For discriminator, a weight-sharing multi-discriminator is designed to improve the performance of model by affine transformations. Experimental results on multi-center UWF image datasets demonstrate that the proposed method can generate retinal images with reasonable details, which helps to enhance the performance of the disease detection model. [ABSTRACT FROM AUTHOR]

• We develop a multi-branch network based on ResNet-34 model, which can extract more deep level features than single network. In addition, an ASPP module is leveraged to refine the extracted deep level features by expanding the receptive field. • A depth-wise attention module is devised to fuse the extracted high-level features, which is used to fuse the features from ASPP module and the last feature extraction layer of the original ResNet-34 model that enforces the network to focus on the salient targets of interest. • We also devise a cross-attention module that learns the distinction and relationship amongst different diseases by channel and spatial attention strategy and integrates the extracted attention map via cross-fusion mode to gain the relevant features of specific-disease. Fundus diseases classification is vital for the health of human beings. However, most of existing methods detect diseases by means of single angle fundus images, which lead to the lack of pathological information. To address this limitation, this paper proposes a novel deep learning method to complete different fundus diseases classification tasks using ultra-wide field scanning laser ophthalmoscopy (SLO) images, which have an ultra-wide field view of 180–200˚. The proposed deep model consists of multi-branch network, atrous spatial pyramid pooling module (ASPP), cross-attention and depth-wise attention module. Specifically, the multi-branch network employs the ResNet-34 model as the backbone to extract feature information, where the ResNet-34 model with two-branch is followed by the ASPP module to extract multi-scale spatial contextual features by setting different dilated rates. The depth-wise attention module can provide the global attention map from the multi-branch network, which enables the network to focus on the salient targets of interest. The cross-attention module adopts the cross-fusion mode to fuse the channel and spatial attention maps from the ResNet-34 model with two-branch, which can enhance the representation ability of the disease-specific features. The extensive experiments on our collected SLO images and two publicly available datasets demonstrate that the proposed method can outperform the state-of-the-art methods and achieve quite promising classification performance of the fundus diseases. [Display omitted] [ABSTRACT FROM AUTHOR]