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Numerous Deep Learning (DL) scenarios have been developed for evolving new healthcare systems that leverage large datasets, distributed computing, and the Internet of Things (IoT). However, the data used in these scenarios tend to be noisy, necessitating the incorporation of robust pre-processing techniques, including data cleaning, preparation, normalization, and addressing imbalances. These steps are crucial for generating a robust dataset for training. Designing frameworks capable of handling such data without compromising efficiency is essential to ensuring robustness. This research aims to propose a novel healthcare framework that selects the best features and enhances performance. This robust deep learning framework, called (R-DLH2O), is designed for forecasting cardiovascular crises. Unlike existing methods, R-DLH2O integrates five distinct phases: robust pre-processing, feature selection, feed-forward neural network, prediction, and performance evaluation. This multi-phase approach ensures superior accuracy and efficiency in crisis prediction, offering a significant advancement in healthcare analytics. H2O is utilized in the R-DLH2O framework for processing big data. The main improvement of this paper lies in the unique form of the Whale Optimization Algorithm (WOA), specifically the Modified WOA (MWOA). The Gaussian distribution approach for random walks was employed with the diffusion strategy to choose the optimal MWOA solution during the growth phase. To validate the R-DLH2O framework, six performance tests were conducted. Surprisingly, the MWOA-2 outperformed other heuristic algorithms in speed, despite exhibiting lower accuracy and scalability. The suggested MWOA was further analyzed using benchmark functions from CEC2005, demonstrating its advantages in accuracy and robustness over WOA. These findings highlight that the framework's processing time is 436 s, mean per-class error is 0.150125, accuracy 95.93%, precision 92.57%, and recall 93.6% across all datasets. These findings highlight the framework's potential to produce significant and robust results, outperforming previous frameworks concerning time and accuracy., Competing Interests: Declarations Competing interests The authors declare no competing interests. Ethics approval The clinical data used for this research was obtained from publicly available deidentified database, Medical Information Mart for Intensive Care (MIMIC-II), and does not require a separate ethics approval or consent obtaining process., (© 2024. The Author(s).)

The mortality risk factors for coronavirus disease (COVID‐19) must be early predicted, especially for severe cases, to provide intensive care before they develop to critically ill immediately. This paper aims to develop an optimized convolution neural network (CNN) for predicting mortality risk factors for COVID‐19 patients. The proposed model supports two types of input data clinical variables and the computed tomography (CT) scans. The features are extracted from the optimized CNN phase and then applied to the classification phase. The CNN model's hyperparameters were optimized using a proposed genetic‐based adaptive momentum estimation (GB‐ADAM) algorithm. The GB‐ADAM algorithm employs the genetic algorithm (GA) to optimize Adam optimizer's configuration parameters, consequently improving the classification accuracy. The model is validated using three recent cohorts from New York, Mexico, and Wuhan, consisting of 3055, 7497,504 patients, respectively. The results indicated that the most significant mortality risk factors are: CD 8+ T Lymphocyte (Count), D‐dimer greater than 1 Ug/ml, high values of lactate dehydrogenase (LDH), C‐reactive protein (CRP), hypertension, and diabetes. Early identification of these factors would help the clinicians in providing immediate care. The results also show that the most frequent COVID‐19 signs in CT scans included ground‐glass opacity (GGO), followed by crazy‐paving pattern, consolidations, and the number of lobes. Moreover, the experimental results show encouraging performance for the proposed model compared with different predicting models. [ABSTRACT FROM AUTHOR]

Detecting COVID-19 cases as early as possible became a critical issue that must be addressed to avoid the pandemic's additional spread and early provide the appropriate treatment to the affected patients. This study aimed to develop a COVID-19 diagnosis and prediction (AIMDP) model that could identify patients with COVID-19 and distinguish it from other viral pneumonia signs detected in chest computed tomography (CT) scans. The proposed system uses convolutional neural networks (CNNs) as a deep learning technology to process hundreds of CT chest scan images and speeds up COVID-19 case prediction to facilitate its containment. We employed the whale optimization algorithm (WOA) to select the most relevant patient signs. A set of experiments validated AIMDP performance. It demonstrated the superiority of AIMDP in terms of the area under the curve-receiver operating characteristic (AUC-ROC) curve, positive predictive value (PPV), negative predictive rate (NPR) and negative predictive value (NPV). AIMDP was applied to a dataset of hundreds of real data and CT images, and it was found to achieve 96% AUC for diagnosing COVID-19 and 98% for overall accuracy. The results showed the promising performance of AIMDP for diagnosing COVID-19 when compared to other recent diagnosing and predicting models. [ABSTRACT FROM AUTHOR]