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Mining spatiotemporal mobility patterns is crucial for optimizing urban planning, enhancing transportation systems, and improving public safety by providing useful insights into human movement and behavior over space and time. As an unsupervised learning technique, time series clustering has gained considerable attention due to its efficiency. However, the existing literature has often overlooked the inherent characteristics of mobility data, including high-dimensionality, noise, outliers, and time distortions. This oversight can lead to potentially large computational costs and inaccurate patterns. To address these challenges, this paper proposes a novel neural network-based method integrating temporal autoencoder and dynamic time warping-based K-means clustering algorithm to mutually promote each other for mining spatiotemporal mobility patterns. Comparative results showed that our proposed method outperformed several time series clustering techniques in accurately identifying mobility patterns on both synthetic and real-world data, which provides a reliable foundation for data-driven decision-making. Furthermore, we applied the method to monthly county-level mobility data during the COVID-19 pandemic in the U.S., revealing significant differences in mobility changes between rural and urban areas, as well as the impact of public response and health considerations on mobility patterns. [ABSTRACT FROM AUTHOR]

The mapping of the physical interactions between biochemical entities enables quantitative analysis of dynamic biological living systems. While developing a precise dynamical model on biological entity interaction is still challenging due to the limitation of kinetic parameter detection of the underlying biological system. This challenge promotes the needs of topology-based models to predict biochemical perturbation patterns. Pure topology-based model, however, is limited on the scale and heterogeneity of biological networks. Here we propose a learning based model that adopts graph convolutional networks to learn the implicit perturbation pattern factors and thus enhance the perturbation pattern prediction on the basic topology model. Our experimental studies on 87 biological models show an average of 73% accuracy on perturbation pattern prediction and outperforms the best topology-based model by 7%, indicating that the graph-driven neural network model is robust and beneficial for accurate prediction of the perturbation spread modeling and giving an inspiration of the implementation of the deep neural networks on biological network modeling. [ABSTRACT FROM AUTHOR]