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Your search keyword '"Timmel, Christiane A."' showing total 7 results
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7 results on '"Timmel, Christiane A."'

2. Investigating the structure of the factor B vWF-A domain/CD55 protein-protein complex using DEER spectroscopy: successes and pitfalls

Author

Lovett, Janet E., Abbott, Rachel J.M., Roversi, Pietro, Johnson, Steven, Caesar, Joseph J.E., Doria, Marianna, Jeschke, Gunnar, Timmel, Christiane R., and Lea, Susan M.

Subjects
Deer, DEER, Distance restraints, CD55, vWF-A, Decay acceleration
Abstract

The electron paramagnetic resonance technique of double electron-electron resonance (DEER) was used to measure nanometre-scale distances between nitroxide spin labels attached to the complement regulatory protein CD55 (also known as decay accelerating factor) and the von Willebrand factor A (vWF-A) domain of factor B. Following a thorough assessment of the quality of the data, distances obtained from good-quality measurements are compared to predicted distances from a previously hypothesised model for the complex and are found to be incompatible. The success of using these distances as restraints in multi-body docking routines is presented critically. ISSN:0026-8976 ISSN:1362-3028

Published
2013

3. Investigating the structure of the factor B vWF-A domain/CD55 protein-protein complex using DEER spectroscopy: Successes and pitfalls

Author

Lovett, Janet E., Abbott, Rachel J.M., Roversi, Pietro, Johnson, Steven, Caesar, Joseph J.E., Doria, Marianna, Jeschke, Gunnar, Timmel, Christiane R., and Lea, Susan M.

Subjects
Deer, vWF-A, CD55, Distance restraints, Decay acceleration, 3. Good health
Abstract

The electron paramagnetic resonance technique of double electron-electron resonance (DEER) was used to measure nanometre-scale distances between nitroxide spin labels attached to the complement regulatory protein CD55 (also known as decay accelerating factor) and the von Willebrand factor A (vWF-A) domain of factor B. Following a thorough assessment of the quality of the data, distances obtained from good-quality measurements are compared to predicted distances from a previously hypothesised model for the complex and are found to be incompatible. The success of using these distances as restraints in multi-body docking routines is presented critically., Molecular Physics, 111 (18-19), ISSN:0026-8976, ISSN:1362-3028

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