1. Minocycline-induced cutaneous hyperpigmentation: confocal laser scanning microscope analysis.
- Author
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Dodiuk-Gad, R. P., Morentin, H. M., Schafer, J., Harel, A., Neudorfer, M., Misonzhnik, F., Gitstein, G., Rozenman, D., Tur, E., and Brenner, S.
- Subjects
SKIN diseases ,DERMATOLOGY ,PIGMENTATION disorders ,DEFICIENCY diseases ,HUMAN skin color - Abstract
Background Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline–induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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