1. Phospholipase A2 inhibitor and LY6/PLAUR domaincontaining protein PINLYP regulates type I interferon innate immunity.
- Author
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Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Legembre, Patrick, Jung, Jae U., Huaping Liang, and Xiaozhen Liang
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TYPE I interferons , *PHOSPHOLIPASE A2 , *NATURAL immunity , *VIRUS diseases , *DENDRITIC cells - Abstract
Type I interferons (IFNs) are the first frontline of the host innate immune response against invading pathogens. Herein, we characterized an unknown protein encoded by phospholipase A2 inhibitor and LY6/PLAUR domain-containing (PINLYP) gene that interacted with TBK1 and induced type I IFN in a TBK1- and IRF3-dependent manner. Loss of PINLYP impaired the activation of IRF3 and production of IFN-ß induced by DNA virus, RNA virus, and various Toll-like receptor ligands in multiple cell types. Because PINLYP deficiency in mice engendered an early embryonic lethality in mice, we generated a conditional mouse in which PINLYP was depleted in dendritic cells. Mice lacking PINLYP in dendritic cells were defective in type I IFN induction and more susceptible to lethal virus infection. Thus, PINLYP is a positive regulator of type I IFN innate immunity and important for effective host defense against viral infection. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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