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Introduction: Cancer is causing death in countries with more or less economic development, and it is expected that the burden will grow worldwide, especially in countries with less developed populations, where about 82% of the global population lives. The aim of this study was to present and estimate trends in incidence, mortality rate and MIR of malignant neoplasm of otherand ill-defined sites of lip, oral cavity and pharynx cancer in Central Serbia from 1999 to 2020. Material and methods: The registry-based study was conducted using the data from the publically accessible Yearbooks of the Institute of Public Health of Serbia: Incidence and Mortality in Central Serbia, from 1999 to 2020. Joinpoint regression was used to determine the trend and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals. Results: A total number of 558 cases (436men and 122women) of other and ill-defined lip, oral cavity and pharynx cancer sites registered in Central Serbia from 1999 to 2020. The crude rate (CR) and age-standardized rate (ASR-W) of incidence in males increased (p

Introduction: Carcinoma of the stratified squamous epithelium of the oral cavity - oral squamous cell carcinoma (OSCC) is an invasive pathological lesion of the epithelium with varying degrees of squamous differentiation. It is characterized by early and extensive metastases, infiltration of adjacent anatomical structures, frequent recurrences, and a relatively low five-year survival rate of less than 50%. The aim of the study to determine the correlation between the analysis of the lymphocytic infiltrate of biopsy specimens with pathohistologically proven metastases of oral squamous cellular carcinoma on postoperative neck dissection specimens. Material and methods: The study included 42 patients with pathohistologically verified oral squamous cellular carcinoma who underwent surgery at the Department of Maxillofacial Surgery of the Clinic of Dental medicine in Niš in the period from 2018 to 2022. The histopathological analysis included the depth of tumor invasion, histopathological analysis of the lymph nodes of neck dissections, analysis of lymphocytic infiltration, and presence of lymphovascularand perineural invasion. Results: It was determined that the depth of invasion is statistically significantly different regarding the degree of lymphocytic infiltration (p=0.004). Invasion of over 4mm was present in 20% of patients with high infiltration, 44.4% of patients with medium infiltration, and 85.7% of patients with low infiltration. Conclusion: Given that the results of the study indicate that the analysis of the lymphocytic infiltrate can be a reliable predictive factor of the appearance of metastases in the lymph nodes of the neck, further research should be directed toward as sociating lymphocytic infiltration with certain biochemical and genetic parameters based on which a plan can be created for neck treatment in the N0 stage of oral squamous cellular carcinoma.

Background: Lip cancer is the most frequent oral cancer. The aim of this study was to present and estimate trends in the incidence and mortality of lip cancer in Central Serbia during a 16-year period, from 1999 to 2014. Material and methods: This registry-based study was carried out based on the data extracted from publicly available Yearbooks of the Institute of Public Health of Serbia - Incidence and Mortality in Central Serbia, from 1999 to 2014. The trend and the annual percentage change (APC) of the incidence and mortality rate with the corresponding 95% confidence intervals were calculated by performing join point regression analyses. Results: A total number of 1,922 cases (1,402 in men and 520 in women) of lip cancer were registered in Central Serbia from 1999 to 2014. The crude rate (CR) and age-standardized rate (ASR-W) of the incidence in males decreased (p=0.001, p