1. Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus.
- Author
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Irie Y, Itokazu N, Anjiki N, Ishige A, Watanabe K, and Keung WM
- Subjects
- Animals, Behavior, Animal, Brain-Derived Neurotrophic Factor genetics, Brain-Derived Neurotrophic Factor metabolism, Disease Models, Animal, Dose-Response Relationship, Drug, Eugenol chemistry, Hindlimb Suspension, Imipramine pharmacology, Male, Metallothionein 3, Mice, Mice, Inbred Strains, Nerve Tissue Proteins genetics, RNA, Messenger biosynthesis, Reverse Transcriptase Polymerase Chain Reaction methods, Swimming, alpha-MSH genetics, alpha-MSH metabolism, Antidepressive Agents therapeutic use, Depression drug therapy, Eugenol therapeutic use, Gene Expression drug effects, Hippocampus drug effects, Nerve Tissue Proteins metabolism, alpha-MSH analogs & derivatives
- Abstract
Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine., (Copyright 2004 Elsevier B.V.)
- Published
- 2004
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