1. Evening types demonstrate reduced SSRI treatment efficacy.
- Author
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McGlashan EM, Drummond SPA, and Cain SW
- Subjects
- Adolescent, Adult, Aged, Antidepressive Agents adverse effects, Depression diagnosis, Depression physiopathology, Depression psychology, Drug Resistance, Female, Humans, Male, Middle Aged, Phenotype, Selective Serotonin Reuptake Inhibitors adverse effects, Time Factors, Treatment Outcome, Young Adult, Activity Cycles, Affect drug effects, Antidepressive Agents therapeutic use, Circadian Rhythm, Depression drug therapy, Selective Serotonin Reuptake Inhibitors therapeutic use
- Abstract
Selective serotonin reuptake inhibitors (SSRIs) have a profound effect on the circadian system's response to environmental light, which may impact treatment outcomes for patients depending on their habitual light exposure patterns. Here, we investigated the relationship between time-of-day preference, depressive symptoms and self-reported antidepressant treatment response. Evening types reported having taken a higher number of antidepressant medications in the previous 5 years and lower SSRI efficacy than morning types. While undergoing SSRI treatment, evening types also reported more depressive symptoms and suicidality. It is concluded that time-of-day preference may prove informative in predicting SSRI treatment responses.
- Published
- 2018
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