21 results on '"Lijuan Zhang"'
Search Results
2. Network analysis of depression and anxiety symptoms in Chinese rheumatoid arthritis patients
- Author
-
Lijuan Zhang, Weiyi Zhu, and Beiwen Wu
- Subjects
Rheumatoid arthritis ,Anxiety ,Depression ,Quality of life ,Network analysis ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background Rheumatoid arthritis (RA) patients are susceptible to comorbid anxiety and depression. From the network model perspective, comorbidity is due to direct interactions between depression and anxiety symptoms. The objective of this study was to assess the network structure of depression and anxiety symptoms in Chinese RA patients and identify the central and bridge symptoms as well as how depression and anxiety symptoms are related to quality of life (QoL) in the network. Methods A total of 402 Chinese RA patients were included in this study. Depression and anxiety symptoms were measured by the Hospital Anxiety and Depression Scale (HADS). R software was used to estimate the network. Specifically, we computed the predictability, expected influence (EI) and bridge expected influence (BEI) for each symptom and showed a flow network of “QoL”. Results Our network revealed that the strongest edge was D2 “See the bad side of things” and D3 “Not feeling cheerful” across the whole network. For centrality indices, D3 “Not feeling cheerful” and D6 “Feeling down” had the highest EI values in the network, while A4 “Trouble relaxing” and D6 “Feeling down” had the highest BEI values of their respective community. As to “QoL”, the strongest direct edge related to it was A1 “Nervousness”. Conclusions “Feeling down” and “Not feeling cheerful” emerged as the strongest central symptoms, while “Trouble relaxing” and “Feeling down” were bridge symptoms in the anxiety-depression network of RA patients. Intervention on depression and anxiety symptoms in nurses should prioritize these symptoms.
- Published
- 2023
- Full Text
- View/download PDF
3. Risk Factors for Anxiety and Depressive Symptoms in Doctors During the Coronavirus Disease 2019 Pandemic
- Author
-
Lanying He, Jian Wang, Lijuan Zhang, Feng Wang, Weiwei Dong, and Wang Zhao
- Subjects
COVID-19 ,anxiety ,depression ,doctors ,mental health ,Psychiatry ,RC435-571 - Abstract
Background: The purpose of our study was to investigate the prevalence of anxiety and depressive symptoms and their risk factors among doctors during the coronavirus disease 2019 (COVID-19) pandemic.Methods: A hospital-based survey study was conducted. Anxiety symptoms were assessed using the Self-Rating Anxiety Scale (SAS), and depressive symptoms were assessed using the Self-Rating Depression Scale (SDS). Multivariable logistic regression was used to analyze anxiety and depressive symptoms across independent variables.Results: A total of 1,521 doctors were included; 11.11% (169/1,521) of the doctors had anxiety symptoms, and 16.90% (257/1,521) had depressive symptoms. Female sex [adjusted odds ratio (aOR), 1.69; 95% confidence interval (CI), 1.21–2.34; P = 0.002] and having a minor child (aOR, 2.31; 95% CI, 1.50–3.56; P < 0.001) were associated with an increased risk of anxiety symptoms. Female sex (aOR, 1.56; 95% CI, 1.18–2.06; P = 0.002) and having a minor child (aOR, 1.48; 95% CI, 1.06–2.01; P = 0.022) were associated with an increased risk of depressive symptoms. Older age (aOR, 0.97; 95% CI, 0.98–0.99; P = 0.008) was associated with a decreased risk of depressive symptoms.Conclusions: Anxiety and depressive symptoms have been common mental health problems in doctors during the COVID-19 pandemic. We found that female sex, having a minor child, and younger age were major risk factors for the development of anxiety and depressive symptoms among doctors during the COVID-19 pandemic.
- Published
- 2021
- Full Text
- View/download PDF
4. Admission Heart Rate Variability Is Associated With Poststroke Depression in Patients With Acute Mild-Moderate Ischemic Stroke
- Author
-
Lanying He, Jian Wang, Lijuan Zhang, Feng Wang, Weiwei Dong, and Hao Yang
- Subjects
acute ischemic stroke ,heart rate variability ,fractal dimension ,depression ,Hamilton ,Psychiatry ,RC435-571 - Abstract
BackgroundStroke has been shown to cause cardiac autonomic dysfunction. Depression is common complication after acute ischemic stroke (AIS). The purpose of this study was to investigate whether decreased heart rate variability (HRV) was related to poststroke depression (PSD) in patients with mild-moderate AIS.MethodsIn this study, we assessed autonomic function of ischemic stroke patients within 72 h from symptom onset by fractal dimension (FD). 503 patients (mean age 65.93 ± 10.19) with mild-moderate AIS underwent FD test after admission. Depressive symptoms were assessed using 17-item Hamilton Depression Rating Scale (HDRS) at baseline (within 7 days) and 3 months. Depression were defined if HDRS >6 points. According to the data of FD, we investigated association with early-onset PSD status and 3-month PSD.Results59.24% (293/503) of patients had early-onset PSD status at baseline, and 38.66% (184/476) of patients had PSD at 3 months. ROC curve analysis shown that the optimal cut point of FD for early-onset PSD status and 3-month PSD were FD ≤ 1.27 and FD ≤ 1.19, respectively. In fully adjusted models, higher NIHSS [adjusted odd ratios (OR), 1.15; 95% confidence interval (CI), 1.05–1.27; P=0.005], younger age (adjusted OR, 1.18; 95% CI, 1.01–1.13; P=0.046), and FD ≤ 1.27 (adjusted OR, 3.31; 95% CI, 2.23–4.92; P
- Published
- 2020
- Full Text
- View/download PDF
5. Associated factors with functional disability and health-related quality of life in Chinese patients with gout: a case-control study
- Author
-
Ting Fu, Haixia Cao, Rulan Yin, Lijuan Zhang, Qiuxiang Zhang, Liren Li, and Zhifeng Gu
- Subjects
Gout ,Functional disability ,Health-related quality of life ,Depression ,Anxiety ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Gout is a painful, inflammatory disease that may cause decreased function and health-related quality of life (HRQoL). Limited study did not take the influence of gout characteristics and anxiety on HRQoL into consideration and there are no studies associated with functional disability in individuals with gout from China. This study aims to investigate the related factors of functional disability and HRQoL in gout patients recruited from China. Methods A total of 226 consecutive gout patients and 232 age- and gender-matched healthy individuals were involved in the study. A series of questionnaires (the Short Form 36 health survey, the Patient Health Questionnaire, the Generalized Anxiety Disorder questionnaire, the 10 cm Visual Analog Scale, and the Health Assessment Questionnaire-Disability Index) were applied. Blood samples were taken to examine the level of serum uric acid. Independent samples t-tests, Chi square tests, U test, Spearman rank correlation, logistic regression modeling, and linear regression were used to analyze the data. Results After adjusted demographic variables, individuals with gout have poorer HRQoL compared to healthy controls. Univariate tests presented that patients with functional disability had longer disease duration, more frequent flares/last year, more severe total pain, more number of tophi, higher degree of depression and anxiety, with a trend toward diabetes, the treatment of colchicine and corticosteroids use, compared to patients without functional disability. Meanwhile, place of residence, hypertension, DM, disease duration, cardiovascular disease, number of flares/last year, total pain, more number of tophi, presence of tender joints, depression, anxiety, currently using colchicine and corticosteroids were correlated significantly with HRQoL. Additionally, multiple regression analysis identified severe pain, depression, and colchicine use as predictors of functional disability. Cardiovascular disease, total pain, number of flares/last year, presence of tender joints, depression, anxiety, colchicine and corticosteroids use contributed to low HRQoL. Conclusions After adjusted demographic variables, gout subjects have poorer HRQoL compared to healthy controls. Chinese gout population experiencing poor HRQoL and functional disability were likely to suffer from gout-related features and psychological problems. The results underscore the need of effective interventions including psychological nursing and appropriate treatment approaches to reduce their functional disability and improve their HRQoL.
- Published
- 2017
- Full Text
- View/download PDF
6. Priming of microglia with <scp>IFN</scp> ‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects
- Author
-
Tao Zhou, Yan Qiao, Lijuan Zhang, Yahui Li, Haili He, Wei-Ke Jiang, Hui He, Zili You, Li Mo, Jinqiang Zhang, and Saini Yi
- Subjects
0301 basic medicine ,Aging ,Neurogenesis ,medicine.medical_treatment ,Population ,Hippocampus ,Biology ,Hippocampal formation ,Interferon-gamma ,Mice ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Cognition ,0302 clinical medicine ,Precursor cell ,medicine ,Animals ,Cognitive Dysfunction ,education ,Neuroinflammation ,education.field_of_study ,Microglia ,Depression ,030104 developmental biology ,medicine.anatomical_structure ,Cytokine ,Neurology ,Cytokines ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Neuroinflammation driven by interferon-gamma (IFN-γ) and microglial activation has been linked to neurological disease. However, the effects of IFN-γ-activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN-γ was administered to mice via intracerebroventricular injection. Mice received intraperitoneal injection of ruxolitinib to inhibit the JAK/STAT1 pathway or injection of minocycline to inhibit microglial activation. During a 7-day period, mice were assessed for depressive-like behaviors and cognitive impairment based on a series of behavioral analyses. Effects of the activated microglia on neural stem/precursor cells (NSPCs) were examined, as was pro-inflammatory cytokine expression by activated microglia. We showed that IFN-γ-injected animals showed long-term adult hippocampal neurogenesis reduction, behavior despair, anhedonia, and cognitive impairment. Chronic activation with IFN-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, MHC II and CD68 up-regulation, and pro-inflammatory cytokine (IL-1β, TNF-α, IL-6) and nitric oxide (NO) release. Microglia isolated from the hippocampus of IFN-γ-injected mice suppressed NSPCs proliferation and stimulated apoptosis of immature neurons. Inhibiting of the JAK/STAT1 pathway in IFN-γ-injected animals to block microglial activation suppressed microglia-mediated neuroinflammation and neurogenic injury, and alleviated depressive-like behaviors and cognitive impairment. Collectively, these findings suggested that priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Targeting microglia by modulating levels of IFN-γ the brain may be a therapeutic strategy for neurodegenerative diseases and psychiatric disorders.
- Published
- 2020
7. Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation
- Author
-
Qiaozhi Wang, Qiuying Zhao, Lei Xie, Dingding Zhang, Guangyi Liu, Zili You, Lijuan Zhang, Yue Han, and Jinqiang Zhang
- Subjects
Male ,medicine.medical_specialty ,Neurogenesis ,Endocrinology, Diabetes and Metabolism ,Minocycline ,Inflammation ,Hippocampus ,Open field ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,medicine ,Animals ,Hippocampus (mythology) ,Weaning ,Biological Psychiatry ,Depressive Disorder ,Microglia ,Depression ,Endocrine and Autonomic Systems ,business.industry ,Maternal Deprivation ,Brain ,030227 psychiatry ,Mice, Inbred C57BL ,Disease Models, Animal ,Psychiatry and Mental health ,medicine.anatomical_structure ,Inflammation Mediators ,medicine.symptom ,business ,Stress, Psychological ,030217 neurology & neurosurgery ,medicine.drug ,Behavioural despair test - Abstract
Exposure to early adversity increases vulnerability to psychiatric disorders in later life. Microglia-mediated inflammation has been linked to psychopathology, so such inflammation may be a target for treating depression. Using a model of depression involving adolescent male C57BL/6J mice subjected to maternal separation, we explored whether using minocycline to mitigate inflammation can alleviate depression-like behaviors. Between postnatal days 1 and 14, male mice were separated from their mothers for 3 h per day. Minocycline (20 mg/kg) was administered intraperitoneally once daily for 2 weeks starting one week after weaning. Then the male mice were subjected to a second stress for 2 weeks. Results from the sucrose preference test, forced swimming test, and open field test showed that maternal separation did not obviously alter behavior of the male mice, but it did increase the risk of depression-like behaviors following a second stress. This increased risk disappeared if minocycline was given preemptively before the second stress. Maternal separation and second stress up-regulated pro-inflammatory markers and down-regulated anti-inflammatory markers in the hippocampus, and they activated microglia and promoted pro-inflammatory transitions in microglia. All these effects were reversed by minocycline. These changes in inflammatory processes correlated with changes in neurogenesis and BDNF expression in the hippocampus. Our results in this mouse model suggest the potential of minocycline for treating psychiatric disorders induced by early adversity.
- Published
- 2019
8. Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress
- Author
-
Hui He, Shiqi Huang, Cheng Peng, Zili You, Minmin Tang, Gangcai Liu, Ying Xiao, Qiuying Zhao, Nan Hu, Xiaofang Xie, and Lijuan Zhang
- Subjects
Male ,Imipramine ,Ginsenosides ,Ginsenoside Rb1 ,Neurogenesis ,Immunology ,Antidepressant ,Major depressive disorder ,Hippocampal formation ,Pharmacology ,Hippocampus ,Mice ,Cellular and Molecular Neuroscience ,In vivo ,Precursor cell ,medicine ,Animals ,RC346-429 ,Pro-neurogenic phenotype ,Behavior, Animal ,Microglia ,Depression ,business.industry ,Research ,General Neuroscience ,Tail suspension test ,PPAR gamma ,medicine.anatomical_structure ,Neurology ,Cytokines ,Neurology. Diseases of the nervous system ,business ,Stress, Psychological ,Behavioural despair test ,medicine.drug - Abstract
Background Anti-inflammatory approaches are emerging as a new strategy for the treatment of depressive disorders. Ginsenoside Rb1 (GRb1), a major component of Panax ginseng, can inhibit inflammatory cascade and alleviate depressive-like behaviors. Microglia can promote or inhibit adult hippocampal neurogenesis according to their functional phenotypes. Here, we examine whether GRb1 may exert antidepressant effects by promoting a pro-neurogenic phenotype of microglia and thereby increasing neurogenesis. Methods The antidepressant effects of GRb1 or the licensed antidepressant imipramine (IMI) were assessed in chronic mild stress (CMS)-exposed male mice. The depressive-like behaviors of mice were evaluated by sucrose preference test, forced swimming test (FST), and tail suspension test (TST). The microglial phenotypes were identified by pro- and anti-inflammatory cytokine expression and morphological properties, analyzed by RT-qPCR, western blotting, and immunofluorescence staining. The effect of GRb1-treated microglia on adult hippocampal neurogenesis in vivo and in vitro was detected using immunofluorescence staining. Results Behavioral assessment indicated that GRb1 or IMI treatment alleviated depressive-like behaviors in CMS-exposed mice. Immunofluorescence examination demonstrated that GRb1 induced a pro-neurogenic phenotype of microglia via activating PPARγ in vivo and in vitro, which were effectively reversed by the PPARγ inhibitor GW9662. In addition, GRb1-treated microglia increased the proliferation and differentiation of neural precursor cells. Conclusions These findings demonstrated that GRb1 alleviated depressive-like behaviors of CMS-exposed male mice mainly through PPARγ-mediated microglial activation and improvement of adult hippocampus neurogenesis.
- Published
- 2021
9. Risk Factors for Anxiety and Depressive Symptoms in Doctors During the Coronavirus Disease 2019 Pandemic
- Author
-
Feng Wang, Lijuan Zhang, Weiwei Dong, Wang Zhao, Jing Wang, and Lanying He
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,RC435-571 ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Pandemic ,medicine ,030212 general & internal medicine ,Depression (differential diagnoses) ,Original Research ,doctors ,Psychiatry ,business.industry ,COVID-19 ,Odds ratio ,anxiety ,Mental health ,Confidence interval ,Psychiatry and Mental health ,depression ,Anxiety ,medicine.symptom ,business ,030217 neurology & neurosurgery ,mental health - Abstract
Background: The purpose of our study was to investigate the prevalence of anxiety and depressive symptoms and their risk factors among doctors during the coronavirus disease 2019 (COVID-19) pandemic.Methods: A hospital-based survey study was conducted. Anxiety symptoms were assessed using the Self-Rating Anxiety Scale (SAS), and depressive symptoms were assessed using the Self-Rating Depression Scale (SDS). Multivariable logistic regression was used to analyze anxiety and depressive symptoms across independent variables.Results: A total of 1,521 doctors were included; 11.11% (169/1,521) of the doctors had anxiety symptoms, and 16.90% (257/1,521) had depressive symptoms. Female sex [adjusted odds ratio (aOR), 1.69; 95% confidence interval (CI), 1.21–2.34; P = 0.002] and having a minor child (aOR, 2.31; 95% CI, 1.50–3.56; P < 0.001) were associated with an increased risk of anxiety symptoms. Female sex (aOR, 1.56; 95% CI, 1.18–2.06; P = 0.002) and having a minor child (aOR, 1.48; 95% CI, 1.06–2.01; P = 0.022) were associated with an increased risk of depressive symptoms. Older age (aOR, 0.97; 95% CI, 0.98–0.99; P = 0.008) was associated with a decreased risk of depressive symptoms.Conclusions: Anxiety and depressive symptoms have been common mental health problems in doctors during the COVID-19 pandemic. We found that female sex, having a minor child, and younger age were major risk factors for the development of anxiety and depressive symptoms among doctors during the COVID-19 pandemic.
- Published
- 2021
10. Admission Heart Rate Variability Is Associated With Poststroke Depression in Patients With Acute Mild-Moderate Ischemic Stroke
- Author
-
Feng Wang, Lanying He, Weiwei Dong, Lijuan Zhang, Jing Wang, and Hao Yang
- Subjects
fractal dimension ,medicine.medical_specialty ,acute ischemic stroke ,lcsh:RC435-571 ,03 medical and health sciences ,0302 clinical medicine ,Rating scale ,lcsh:Psychiatry ,Internal medicine ,mental disorders ,Medicine ,Heart rate variability ,In patient ,Hamilton ,Stroke ,Depression (differential diagnoses) ,Original Research ,Psychiatry ,business.industry ,heart rate variability ,medicine.disease ,Confidence interval ,030227 psychiatry ,Psychiatry and Mental health ,Ischemic stroke ,depression ,Cardiology ,business ,Complication ,030217 neurology & neurosurgery - Abstract
BackgroundStroke has been shown to cause cardiac autonomic dysfunction. Depression is common complication after acute ischemic stroke (AIS). The purpose of this study was to investigate whether decreased heart rate variability (HRV) was related to poststroke depression (PSD) in patients with mild-moderate AIS.MethodsIn this study, we assessed autonomic function of ischemic stroke patients within 72 h from symptom onset by fractal dimension (FD). 503 patients (mean age 65.93 ± 10.19) with mild-moderate AIS underwent FD test after admission. Depressive symptoms were assessed using 17-item Hamilton Depression Rating Scale (HDRS) at baseline (within 7 days) and 3 months. Depression were defined if HDRS >6 points. According to the data of FD, we investigated association with early-onset PSD status and 3-month PSD.Results59.24% (293/503) of patients had early-onset PSD status at baseline, and 38.66% (184/476) of patients had PSD at 3 months. ROC curve analysis shown that the optimal cut point of FD for early-onset PSD status and 3-month PSD were FD ≤ 1.27 and FD ≤ 1.19, respectively. In fully adjusted models, higher NIHSS [adjusted odd ratios (OR), 1.15; 95% confidence interval (CI), 1.05–1.27; P=0.005], younger age (adjusted OR, 1.18; 95% CI, 1.01–1.13; P=0.046), and FD ≤ 1.27 (adjusted OR, 3.31; 95% CI, 2.23–4.92; P
- Published
- 2020
11. Depression has an impact on disease activity and health-related quality of life in rheumatoid arthritis: A systematic review and meta-analysis
- Author
-
Weiyi Zhu, Lijuan Zhang, and Pingping Cai
- Subjects
medicine.medical_specialty ,PsycINFO ,Cochrane Library ,Severity of Illness Index ,Arthritis, Rheumatoid ,03 medical and health sciences ,Disability Evaluation ,0302 clinical medicine ,Rheumatology ,Quality of life ,Internal medicine ,Surveys and Questionnaires ,Medicine ,Humans ,030212 general & internal medicine ,Depression (differential diagnoses) ,Pain Measurement ,030203 arthritis & rheumatology ,business.industry ,Depression ,medicine.disease ,Mental health ,Arthralgia ,Affect ,Functional Status ,Strictly standardized mean difference ,Rheumatoid arthritis ,Meta-analysis ,Quality of Life ,business - Abstract
Objective The aim of this study was to explore the impact of depression on pain, disease activity, functional disability and quality of life in patients with rheumatoid arthritis (RA). Methods English (PubMed, the Cochrane Library, Web of Science and PsycINFO) and Chinese (Wan Fang Database and Chinese National Knowledge Infrastructure) databases were systematically and independently searched from their inception until 30 September, 2019. Studies evaluating the impact of depression on pain, disease activity, functional disability and quality of life with the use of the Short Form-36 questionnaire (SF-36) scoring system were included. Statistical analyses were performed with Revman5.3. Data were pooled using a fixed or random-effects model according to heterogeneity. Results A total of 7 identified studies matched the inclusion criteria, reporting on a total of 1078 patients with RA in the analysis. The total Disease Activity Score in 28 joints was significantly higher in patients with depression than in patients without depression [standardized mean difference (SMD) =0.47, 95% CI 0.10-0.85, P = .01]. All SF-36 dimensions (physical function, role physical function, emotional role function, vitality, mental health, social function, body pain, general health, physical component scale, mental component scale) were lower in patients with depression than in groups without depression. Interestingly, the results of this meta-analysis showed no significant difference between patients with and without depression in pain (SMD = 0.57, 95% CI - 0.03-1.17, P = .06) and functional disability (SMD = 0.48, 95% CI - 0.03-0.99, P = .43). Conclusion This meta-analysis showed that RA patients with depression tended to have higher disease activity and lower quality of life than patients without depression.
- Published
- 2019
12. Functional disability associated with disease and quality-of-life parameters in Chinese patients with rheumatoid arthritis
- Author
-
Qiuxiang Zhang, Juan Ji, Lijuan Zhang, Liren Li, Ting Fu, Zhifeng Gu, and Rulan Yin
- Subjects
Adult ,Male ,musculoskeletal diseases ,Quality of life ,China ,medicine.medical_specialty ,Functional disability ,Population ,Disease ,Logistic regression ,Hospital Anxiety and Depression Scale ,lcsh:Computer applications to medicine. Medical informatics ,Arthritis, Rheumatoid ,Disability Evaluation ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Prevalence ,Health Status Indicators ,Humans ,Medicine ,030212 general & internal medicine ,Rheumatoid arthritis ,education ,Aged ,030203 arthritis & rheumatology ,education.field_of_study ,Depression ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,General Medicine ,Middle Aged ,Stepwise regression ,medicine.disease ,Arthralgia ,Rheumatology ,Cross-Sectional Studies ,Logistic Models ,Physical therapy ,Joint mobility ,lcsh:R858-859.7 ,Female ,business - Abstract
Background As an important outcome measure among rheumatoid arthritis (RA) patients, functional disability may contribute to unemployment, loss of work productivity, and impaired quality of life. However, little is known about the risk factors of functional disability in Chinese RA patients. This study aimed (1) to examine the prevalence of functional disability in Chinese RA patients; (2) to explore factors associated with the health assessment questionnaire-disability index (HAQ-DI). Methods A total of 101 RA patients in this cross-sectional study underwent standardized laboratory examinations and responded to the questionnaire for demographic data, the HAQ-DI for functional disability, the Compliance Questionnaire on Rheumatology (CQR) for medication adherence, the Hospital Anxiety and Depression Scale (HADS) for psychological status, and the Short Form 36 health survey (SF-36) for quality of life. Pain, grip/pinch strength, disease activity, and large joint mobility were recorded. Independent samples t-tests, chi-square analyses, and logistic regression modeling were used to analyze the data. Results The mean ± SD age of RA patients was 54.9 ± 11.9 years. Approximately 15.8% RA patients in mainland China experience functional disability (defined as a HAQ-DI score ≥ 1). Long disease duration, pain, high disease activity, a larger number of tender and swollen joints, high C-reactive protein (CRP) level, decreased grip strength, and limitation of shoulder, elbow, wrist, knee, and ankle motion were associated with the HAQ-DI. Participants with functional disability tended to have more severe depressive symptoms and a lower quality of life compared with individuals without functional disability. Stepwise logistic regression analyses found that limitation of wrist extension (P = 0.001) and lower body pain (BP) score (P = 0.001) explained higher HAQ-DI score. Conclusions The present study reported that functional disability was common in Chinese RA patients. A low quality of life and limitation of joint mobility had great impacts on functional disability in Chinese RA patients. Targeted and culturally sensitive interventions should be strengthened to delay the onset of disabilities of this population.
- Published
- 2017
13. Effects of psychological interventions for patients with osteoarthritis: a systematic review and meta-analysis
- Author
-
Lijuan Zhang, Ting Fu, Yan He, Zhu Li, Rulan Yin, Qiuxiang Zhang, Wenting Fu, and Biyu Shen
- Subjects
China ,medicine.medical_specialty ,Psychological intervention ,PsycINFO ,Anxiety ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Osteoarthritis ,medicine ,Humans ,Fatigue ,Applied Psychology ,Depression (differential diagnoses) ,030203 arthritis & rheumatology ,Depression ,business.industry ,Cognitive restructuring ,Jadad scale ,Psychiatry and Mental health ,Clinical Psychology ,Mental Health ,Meta-analysis ,Physical therapy ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
The aim of this study was to determine the effects of psychological interventions (e.g. cognitive restructuring, relaxation) on physiological and psychological health in osteoarthritis patients. A systematic literature search was done using PubMed, Embase, PsycINFO, Web of Science, China National Knowledge Infrastructure, and Wanfang Database through November 2016. Studies were included if they used a randomized controlled trial designed to explore the effects of psychological interventions in osteoarthritis patients. Two independent authors assessed the methodological quality of the trials using criteria outlined by Jadad et al. Meta-analysis was done with the Revman5.0. Twelve randomized controlled trials, including 1307 osteoarthritis patients, met the study inclusion criteria. Meta-analysis showed that psychological interventions could reduce the levels of pain [standard mean difference (SMD) -0.28, 95% CI -0.48, -0.08, P-value 0.005)] and fatigue (SMD -0.18, 95% CI -0.34, -0.01, P-value 0.04). In addition, psychological interventions significantly improved osteoarthritis patients' self-efficacy (SMD 0.58, 95% CI 0.40, 0.75, P-value 0.00) and pain coping (MD 1.64, 95% CI 0.03, 3.25, P-value 0.05). Although the effects on physical function, anxiety, depression, psychological disability were in the expected direction, they were not statistically significant. In conclusion, the role of psychological interventions in the management of osteoarthritis remains equivocal. Some encouraging results were seen with regard to pain, pain coping, self-efficacy, and fatigue. We believe that more methodologically rigorous large-scale randomized controlled trials are necessary to answer this study question.
- Published
- 2017
14. Prevalence of Depression in Ankylosing Spondylitis: A Systematic Review and Meta-Analysis
- Author
-
Lijuan Zhang, Shiguang Liu, Yaping Wu, and Weiyi Zhu
- Subjects
medicine.medical_specialty ,Ankylosing spondylitis ,business.industry ,Depression ,PsycINFO ,Knowledge infrastructure ,Review Article ,medicine.disease ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,Meta-analysis ,0302 clinical medicine ,Strictly standardized mean difference ,Sample size determination ,Internal medicine ,Relative risk ,medicine ,Systematic review ,business ,030217 neurology & neurosurgery ,Biological Psychiatry ,Depression (differential diagnoses) - Abstract
The aim of this study was to provide a summary estimate of depression prevalence among people with ankylosing spondylitis (AS) in comparison to those without AS. A systematic literature search was conducted using PubMed, Embase, PsycINFO, Web of Science, the Cochrane database library, China National Knowledge Infrastructure, and Wanfang Database from their inception to December 2016. The results showed that thirty-one eligible studies involving 8,106 patients were analyzed. Fifteen methods of defining depression were reported. The overall pooled prevalence of depression was 35% (95% CI, 28-43%), with high between-study heterogeneity (I2=98.8%, p
- Published
- 2019
15. Associated factors with functional disability and health-related quality of life in Chinese patients with gout: a case-control study
- Author
-
Liren Li, Qiuxiang Zhang, Haixia Cao, Zhifeng Gu, Lijuan Zhang, Rulan Yin, and Ting Fu
- Subjects
Adult ,Male ,medicine.medical_specialty ,lcsh:Diseases of the musculoskeletal system ,Gout ,Functional disability ,Health-related quality of life ,Population ,Anxiety ,03 medical and health sciences ,Disability Evaluation ,0302 clinical medicine ,Rheumatology ,Quality of life ,Asian People ,Epidemiology ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,education ,Depression (differential diagnoses) ,030203 arthritis & rheumatology ,education.field_of_study ,business.industry ,Depression ,Middle Aged ,medicine.disease ,Patient Health Questionnaire ,Case-Control Studies ,Physical therapy ,Quality of Life ,Female ,Generalized Anxiety Disorder Questionnaire ,medicine.symptom ,lcsh:RC925-935 ,business ,Research Article - Abstract
Background Gout is a painful, inflammatory disease that may cause decreased function and health-related quality of life (HRQoL). Limited study did not take the influence of gout characteristics and anxiety on HRQoL into consideration and there are no studies associated with functional disability in individuals with gout from China. This study aims to investigate the related factors of functional disability and HRQoL in gout patients recruited from China. Methods A total of 226 consecutive gout patients and 232 age- and gender-matched healthy individuals were involved in the study. A series of questionnaires (the Short Form 36 health survey, the Patient Health Questionnaire, the Generalized Anxiety Disorder questionnaire, the 10 cm Visual Analog Scale, and the Health Assessment Questionnaire-Disability Index) were applied. Blood samples were taken to examine the level of serum uric acid. Independent samples t-tests, Chi square tests, U test, Spearman rank correlation, logistic regression modeling, and linear regression were used to analyze the data. Results After adjusted demographic variables, individuals with gout have poorer HRQoL compared to healthy controls. Univariate tests presented that patients with functional disability had longer disease duration, more frequent flares/last year, more severe total pain, more number of tophi, higher degree of depression and anxiety, with a trend toward diabetes, the treatment of colchicine and corticosteroids use, compared to patients without functional disability. Meanwhile, place of residence, hypertension, DM, disease duration, cardiovascular disease, number of flares/last year, total pain, more number of tophi, presence of tender joints, depression, anxiety, currently using colchicine and corticosteroids were correlated significantly with HRQoL. Additionally, multiple regression analysis identified severe pain, depression, and colchicine use as predictors of functional disability. Cardiovascular disease, total pain, number of flares/last year, presence of tender joints, depression, anxiety, colchicine and corticosteroids use contributed to low HRQoL. Conclusions After adjusted demographic variables, gout subjects have poorer HRQoL compared to healthy controls. Chinese gout population experiencing poor HRQoL and functional disability were likely to suffer from gout-related features and psychological problems. The results underscore the need of effective interventions including psychological nursing and appropriate treatment approaches to reduce their functional disability and improve their HRQoL.
- Published
- 2017
16. Erratum to: Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis
- Author
-
Liren Li, Qiuxiang Zhang, Rulan Yin, Lijuan Zhang, Zhifeng Gu, Xianhua Wu, Ting Fu, Ze Wang, and Jing Wang
- Subjects
Adult ,Male ,Quality of life ,medicine.medical_specialty ,lcsh:Diseases of the musculoskeletal system ,Hand Joints ,Hand joint destruction ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Rheumatology ,Internal medicine ,Jing wang ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Disease activity ,Rheumatoid arthritis ,Exercise ,Aged ,030203 arthritis & rheumatology ,030222 orthopedics ,Depression ,business.industry ,Middle Aged ,medicine.disease ,Dermatology ,Hand joint ,Cross-Sectional Studies ,Orthopedic surgery ,Physical therapy ,Female ,lcsh:RC925-935 ,Erratum ,business ,Research Article - Abstract
Background There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors of hand joint destruction among RA patients from Nantong China. In addition, we wanted to examine the differences between functional capacity, psychological status, and quality of life in patients with hand joint destruction compared to those without hand joint destruction. Methods A cross-sectional study was conducted from the Affiliated Hospital of Nantong University between July 2015 and June 2016. RA patients completed questionnaires for demographic or clinical variables, the 10-cm Visual Analog Scale for pain, the 28-joint Disease Activity Score-erythrocyte sedimentation rate for disease activity, the Health Assessment Questionnaire-disability index for physical function, the Hospital Anxiety and Depression Scale for anxiety and depression, and the Short Form 36 health survey for quality of life. Laboratory examinations were taken to obtain some biochemical indicators (e.g., rheumatoid factor, anti-cyclic citrullinated peptide antibody). X-ray assessment of hand was performed and hand joint destruction was defined as Sharp score > 0. Independent sample t-test, Mann–Whitney U-test, Chi-square test, and multivariate analysis using backward stepwise logistic regression model were used to analyze these data. Results One hundred and sixty-one RA patients were included in this study. Radiographic findings revealed that almost 47.2% (n = 76) of patients had hand joint destruction. Multivariate analysis found that education ≤ 9 years (p = 0.041), anti-cyclic citrullinated peptide antibody positive (p = 0.021), high disease activity (p = 0.020), and long disease duration (p
- Published
- 2017
17. Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis
- Author
-
Rulan Yin, Lijuan Zhang, Qiuxiang Zhang, Biyu Shen, and Ting Fu
- Subjects
medicine.medical_specialty ,PsycINFO ,Comorbidity ,Anxiety ,Hospital Anxiety and Depression Scale ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Prevalence ,Humans ,Lupus Erythematosus, Systemic ,Psychiatry ,Depression (differential diagnoses) ,030203 arthritis & rheumatology ,Psychiatric Status Rating Scales ,business.industry ,Depression ,Beck Depression Inventory ,Mental health ,Psychiatry and Mental health ,Meta-analysis ,Sample size determination ,Systematic review ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
Background Systemic lupus erythematosus (SLE) patients are at high risk for depression and anxiety. However, the estimated prevalence of these disorders varies substantially between studies. This systematic review aimed to establish pooled prevalence levels of depression and anxiety among adult SLE patients. Methods We systematically reviewed databases including PubMed, Embase, PsycINFO, and the Cochrane database library from their inception to August 2016. Studies presenting data on depression and/or anxiety in adult SLE patients and having a sample size of at least 60 patients were included. A random-effect meta-analysis was conducted on all eligible data. Results A total of 59 identified studies matched the inclusion criteria, reporting on a total of 10828 adult SLE patients. Thirty five and thirteen methods of defining depression and anxiety were reported, respectively. Meta-analyses revealed that the prevalence of major depression and anxiety were 24% (95% CI, 16%-31%, I2 = 95.2%) and 37% (95% CI, 12%–63%, I2 = 98.3%) according to clinical interviews. Prevalence estimates of depression were 30% (95% CI, 22%–38%, I2 = 91.6%) for the Hospital Anxiety and Depression Scale with thresholds of 8 and 39% (95% CI, 29%–49%, I2 = 88.2%) for the 21-Item Beck Depression Inventory with thresholds of 14, respectively. The main influence on depression prevalence was the publication years of the studies. In addition, the corresponding pooled prevalence was 40% (95% CI, 30%–49%, I2 = 93.0%) for anxiety according to the Hospital Anxiety and Depression Scale with a cutoff of 8 or more. Conclusions The prevalence of depression and anxiety was high in adult SLE patients. It indicated that rheumatologists should screen for depression and anxiety in their patients, and referred them to mental health providers in order to identify effective strategies for preventing and treating depression and anxiety among adult SLE patients. Trial registration Current Meta-analysis PROSPERO Registration Number: CRD 42016044125. Registered 4 August 2016. Electronic supplementary material The online version of this article (doi:10.1186/s12888-017-1234-1) contains supplementary material, which is available to authorized users.
- Published
- 2016
18. Effectiveness of telephone-based interventions on health-related quality of life and prognostic outcomes in breast cancer patients and survivors-A meta-analysis
- Author
-
Rulan Yin, Qiuxiang Zhang, Haoyang Chen, Biyu Shen, Ting Fu, and Lijuan Zhang
- Subjects
Counseling ,medicine.medical_specialty ,Psychological intervention ,MEDLINE ,Breast Neoplasms ,Anxiety ,Cochrane Library ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Quality of life ,Humans ,Medicine ,Survivors ,030212 general & internal medicine ,Fatigue ,Depression ,business.industry ,Prognosis ,medicine.disease ,Self Efficacy ,Confidence interval ,Telephone ,Oncology ,030220 oncology & carcinogenesis ,Meta-analysis ,Quality of Life ,Physical therapy ,Female ,medicine.symptom ,business - Abstract
The aim of this meta-analysis was to evaluate the effect of telephone-based interventions on prognostic outcomes and health-related quality of life (HRQoL) in breast cancer patients and survivors. A systematic search of the Cochrane Library, Web of science, Medline, EMBASE, CNKI and CBM database was carried out. Randomised, controlled trials (RCTs) examining the effects of telephone-based intervention versus a control group receiving no telephone intervention, on prognostic outcomes and HRQoL with breast cancer were included. A meta-analysis was conducted to quantify the effects of telephone-based interventions on anxiety, depression, fatigue, self-efficiency, physiological function, social-domestic function and quality of life. In total, 14 studies involving 2002 participants were included. Due to the effect of telephone-based interventions, statistically significant results were found on anxiety (standard mean difference [SMD] = −0.16, 95% confidence intervals [CI] [0.01, 0.30], p = .04), self-efficiency (SMD = 0.22, 95% CI [−0.34, −0.10], p = .0004), social-domestic function (SMD = 0.19, 95% CI [−0.35, −0.03], p = .02) and quality of life (SMD = 0.54, 95% CI [−1.00, −0.08], p = .02). Although the effects on depression, fatigue and physiological function were in the expected direction, these effects were not statistically significant (p > .05) based on the insufficient evidence.
- Published
- 2017
19. Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis.
- Author
-
Lijuan Zhang, Ting Fu, Rulan Yin, Qiuxiang Zhang, and Biyu Shen
- Subjects
- *
MENTAL depression risk factors , *SYSTEMIC lupus erythematosus , *ANXIETY , *DISEASE prevalence , *SYSTEMATIC reviews , *META-analysis ,DISEASES in adults - Abstract
Background: Systemic lupus erythematosus (SLE) patients are at high risk for depression and anxiety. However, the estimated prevalence of these disorders varies substantially between studies. This systematic review aimed to establish pooled prevalence levels of depression and anxiety among adult SLE patients. Methods: We systematically reviewed databases including PubMed, Embase, PsycINFO, and the Cochrane database library from their inception to August 2016. Studies presenting data on depression and/or anxiety in adult SLE patients and having a sample size of at least 60 patients were included. A random-effect meta-analysis was conducted on all eligible data. Results: A total of 59 identified studies matched the inclusion criteria, reporting on a total of 10828 adult SLE patients. Thirty five and thirteen methods of defining depression and anxiety were reported, respectively. Metaanalyses revealed that the prevalence of major depression and anxiety were 24% (95% CI, 16%-31%, I2 = 95.2%) and 37% (95% CI, 12%-63%, I2 = 98.3%) according to clinical interviews. Prevalence estimates of depression were 30% (95% CI, 22%-38%, I2 = 91.6%) for the Hospital Anxiety and Depression Scale with thresholds of 8 and 39% (95% CI, 29%-49%, I2 = 88.2%) for the 21-Item Beck Depression Inventory with thresholds of 14, respectively. The main influence on depression prevalence was the publication years of the studies. In addition, the corresponding pooled prevalence was 40% (95% CI, 30%-49%, I2 = 93.0%) for anxiety according to the Hospital Anxiety and Depression Scale with a cutoff of 8 or more. Conclusions: The prevalence of depression and anxiety was high in adult SLE patients. It indicated that rheumatologists should screen for depression and anxiety in their patients, and referred them to mental health providers in order to identify effective strategies for preventing and treating depression and anxiety among adult SLE patients. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
20. Sleep quality in Chinese patients with rheumatoid arthritis: contributing factors and effects on health-related quality of life.
- Author
-
Genkai Guo, Ting Fu, Rulan Yin, Lijuan Zhang, Qiuxiang Zhang, Yunfei Xia, Liren Li, and Zhifeng Gu
- Subjects
RHEUMATOID arthritis ,HEALTH of patients ,HEALTH ,SLEEP ,QUALITY of life ,ANTIRHEUMATIC agents ,C-reactive protein ,PATIENTS ,PREVENTION ,THERAPEUTICS - Abstract
Background: Poor sleep quality is common in rheumatoid arthritis (RA) patients and may lead to disease aggravation and decreased health-related quality of life (HRQoL). The increasing prevalence of poor sleep in RA patients is associated with adverse demographic, clinical, and psychological characteristics. However, there are currently no known reported studies related to the effects of sleep quality on HRQoL in RA patients from China. This cross-sectional study aims to evaluate the contributors of poor sleep and the effects of sleep quality on HRQoL in Chinese RA patients. Methods: A self-report survey was administered to 131 RA patients and 104 healthy individuals using the Pittsburgh Sleep Quality Index (PSQI) for sleep quality. RA patients completed the Hospital Anxiety and Depression Scale for anxiety and depression, the 28-joint Disease Activity Score for disease activity, the 10 cm Visual Analog Scale for pain, the Health Assessment Questionnaire-Disability Index for functional capacity and the Short Form 36 health survey for HRQoL. Blood samples were taken to gain some biochemical indicators (e.g., erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and anti-cyclic citrullinated peptide). Independent samples t-tests, Chi square analysis, logistic regression modeling and linear regression were used to analyze these data. Results: Our results found that the prevalence of poor sleep (PSQI = 5) was 78.6% and the mean global score of PSQI was 7.93 (SD 3.98) in patients, which were significantly higher than the controls (18.7% and 3.88 (SD 1.89), respectively). There were significant correlations among synthetic disease-modifying antirheumatic drugs, erythrocyte sedimentation rate, pain, disease activity, functional capacity, anxiety/depression and sleep quality in RA patients. Meanwhile, logistic regression models identified disease activity and depression as predictors of poor sleep quality. Poor RA sleepers had impaired HRQoL than good RA sleepers, and sleep quality was independently and significantly associated with social function and mental components summary. Conclusions: The majority of Chinese RA patients suffered from poor sleep, which significantly impairs their HRQoL. The data suggested the need for holistic assessment and management of RA patients and the importance of objective interventions to improve their sleep quality and finally to improve their HRQoL. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
21. Sleep quality in Chinese patients with rheumatoid arthritis: contributing factors and effects on health-related quality of life
- Author
-
Qiuxiang Zhang, Genkai Guo, Lijuan Zhang, Yunfei Xia, Rulan Yin, Zhifeng Gu, Liren Li, and Ting Fu
- Subjects
Adult ,Male ,Sleep Wake Disorders ,Quality of life ,medicine.medical_specialty ,China ,Visual Analog Scale ,Cross-sectional study ,Visual analogue scale ,Health Status ,Rheumatoid Arthritis ,Anxiety ,Hospital Anxiety and Depression Scale ,Logistic regression ,Pittsburgh Sleep Quality Index ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Sleep Initiation and Maintenance Disorders ,medicine ,Prevalence ,Humans ,Disease activity ,Aged ,Pain Measurement ,030203 arthritis & rheumatology ,business.industry ,Depression ,Research ,Public Health, Environmental and Occupational Health ,General Medicine ,Middle Aged ,Sleep quality ,Cross-Sectional Studies ,Logistic Models ,Physical therapy ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background Poor sleep quality is common in rheumatoid arthritis (RA) patients and may lead to disease aggravation and decreased health-related quality of life (HRQoL). The increasing prevalence of poor sleep in RA patients is associated with adverse demographic, clinical, and psychological characteristics. However, there are currently no known reported studies related to the effects of sleep quality on HRQoL in RA patients from China. This cross-sectional study aims to evaluate the contributors of poor sleep and the effects of sleep quality on HRQoL in Chinese RA patients. Methods A self-report survey was administered to 131 RA patients and 104 healthy individuals using the Pittsburgh Sleep Quality Index (PSQI) for sleep quality. RA patients completed the Hospital Anxiety and Depression Scale for anxiety and depression, the 28-joint Disease Activity Score for disease activity, the 10 cm Visual Analog Scale for pain, the Health Assessment Questionnaire-Disability Index for functional capacity and the Short Form 36 health survey for HRQoL. Blood samples were taken to gain some biochemical indicators (e.g., erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and anti-cyclic citrullinated peptide). Independent samples t-tests, Chi square analysis, logistic regression modeling and linear regression were used to analyze these data. Results Our results found that the prevalence of poor sleep (PSQI ≥ 5) was 78.6% and the mean global score of PSQI was 7.93 (SD 3.98) in patients, which were significantly higher than the controls (18.7% and 3.88 (SD 1.89), respectively). There were significant correlations among synthetic disease-modifying antirheumatic drugs, erythrocyte sedimentation rate, pain, disease activity, functional capacity, anxiety/depression and sleep quality in RA patients. Meanwhile, logistic regression models identified disease activity and depression as predictors of poor sleep quality. Poor RA sleepers had impaired HRQoL than good RA sleepers, and sleep quality was independently and significantly associated with social function and mental components summary. Conclusions The majority of Chinese RA patients suffered from poor sleep, which significantly impairs their HRQoL. The data suggested the need for holistic assessment and management of RA patients and the importance of objective interventions to improve their sleep quality and finally to improve their HRQoL. Electronic supplementary material The online version of this article (doi:10.1186/s12955-016-0550-3) contains supplementary material, which is available to authorized users.
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.