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Background: It is well known that unexpected pandemic has led to an increase in mental health problems among a variety of populations., Methods: In this study, an online non-probability sample survey was used to anonymously investigate the anxiety and depression symptoms among medical staff under the COVID-19 outbreak. The questionnaire included Perceived Stress Scale-10 (PSS-10), Generalized Anxiety Disorder 7-Item Scale (GAD-7) and Patient Health Questionnaire-9 (PHQ-9). Factors associated with anxiety and depression symptoms were estimated by logistic regression analysis., Results: A total of 1090 medical staff were investigated in this study. The estimated self-reported rates of anxiety symptoms, depression symptoms and both of the two were 13.3%, 18.4% and 23.9% respectively. Factors associated with self-reported anxiety symptoms include married status (OR=2.3, 95%CI: 1.2, 4.4), not living alone (OR=0.4, 95%CI: 0.2, 0.7), never confiding their troubles to others (OR=2.2, 95%CI: 1.4, 3.5) and higher stress (OR=14.4, 95%CI: 7.8, 26.4). Factors associated with self-reported depression symptoms include not living alone (OR=0.4, 95%CI: 0.3, 0.7), sometimes/often getting care from neighbours (OR=0.6, 95%CI: 0.4, 0.9), never confiding their troubles to others (OR=2.0, 95%CI: 1.3, 3.0) and higher stress (OR=9.7, 95%CI: 6.2, 15.2)., Limitations: The study was a non-probability sample survey. Besides, scales used in this study can only identify mental health states., Conclusions: Under outbreak of COVID-19, self-reported rates of anxiety symptoms and depression symptoms were high in investigated medical staff. Psychological interventions for those at high risk with common mental problems should be integrated into the work plan to fight against the epidemic., (Copyright © 2020. Published by Elsevier B.V.)

Objective To analyze the correlation between serum monocyte chemotactic protein-2 (MCP-2), growth differentiation factor-15 (GDF-15) and personality characteristics of patients with major depressive disorder (MDD) and their effects on suicidal ideation. Methods A total of 149 MDD patients who were admitted to The First Psychiatric Hospital of Harbin from January 2022 to June 2023 were selected as MDD group, and 75 healthy volunteers who underwent physical examination during the same period were selected as healthy group. Enzyme linked immunosorbent assay was used to detect serum levels of MCP-2 and GDF-15, and the personality traits of MDD patients were evaluated using the Eysenck Personality Questionnaire (EPQ). The Pearson method was used to analyze the correlation between serum MCP-2, GDF-15, and EPQ score. Based on the presence or absence of suicidal ideation, multivariate logistic regression and receiver operating characteristic (ROC) curves were used to analyze the predictive value of each factor on suicidal ideation in MDD patients. Results The levels of serum MCP-2 and GDF-15 in MDD group were higher than those in healthy group (P＜0.05). Among the 149 MDD patients, 56 cases (37.58%) had suicidal ideation. Higher HAMD score, poor sleep quality, severe anxiety, history of attempted suicide, and higher levels of serum MCP-2 and GDF-15 were independent risk factors for suicidal ideation in MDD patients (P＜0.05). The AUC of serum MCP-2, GDF-15 alone and in combination for predicting suicidal ideation in MDD were 0.679, 0.675 and 0.819, respectively. Conclusion The levels of serum MCP-2 and GDF-15 in MDD patients are closely relate to the personality characteristics of MDD patients, higher levels of MCP-2 and GDF-15 are risk factors for suicidal ideation in MDD patients.