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Irritant dermatosis is a non-specific reactive change on the skin. In most cases it represents the summated effects induced by various agents. Not only the shortened recovery phases of the skin but also a dispositional factor are important. Such changes, which are relatively common in some vocations but are usually only slight, cannot, as a rule, be regarded as signs of illness. Nevertheless, attention should be drawn to the necessity of intensive skin care and observation of the recovery phases because the frequency of irritant dermatosis can increase with increasing length of employment.

A catalogue concerning adequate concentrations of pesticides for use in patch testing is presented. These recommendations are based on author's experiences also utilizing case reports both of the GDR and of the international literature. In particular case reports are mentioned on contact dermatitis due to Metham-sodium, Dazomet, Zineb and Maneb, Benomyl, Captan, Propachlor, Phenmedipham, 2,4-D and 2,4,5-T, Dichlorvos, Parathionmethyl, Trichlorfon. The recommended patch test concentrations should be made a subject for discussion and further investigations.

Basing on the determination of ID50 and IT50 after Kligman and Wooding but involving our own modification, the primarily irritating effect of certain industrial substances on experimental animals' and humans' skin was comparatively evaluated. Mutual experimental studies have been carried out in Dermatological Clinics in Leipzig and Rostock and Dermatological Clinic at the Medical Academy of Lódź. The results were found to be generally consistent in humans and animals. Extension of international cooperation and information and results on the determination of industrial substances adverse effects seem to be necessary.