18 results on '"Bussières, Jean-François"'
Search Results
2. Canadian monitoring program of the surface contamination with 11 antineoplastic drugs in 124 centers.
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Pinet, Emma, Cirtiu, Ciprian Mihai, Caron, Nicolas, Bussières, Jean-François, and Tanguay, Cynthia
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ENVIRONMENTAL monitoring ,HEALTH facilities ,LIQUID chromatography ,ANTINEOPLASTIC agents ,OCCUPATIONAL exposure ,HAZARDOUS substance release ,HYGIENE ,SANITATION ,GEMCITABINE ,PLATINUM ,HOSPITAL pharmacies ,DESCRIPTIVE statistics ,CYCLOPHOSPHAMIDE ,OCCUPATIONAL hazards ,MASS spectrometry ,INDUSTRIAL hygiene - Abstract
Introduction: Occupational exposure to antineoplastic drugs can lead to long-term adverse effects on workers' health. A reproducible Canadian surface monitoring program was established in 2010. The objective was to describe contamination with 11 antineoplastic drugs measured on 12 surfaces among hospitals participating in this annual monitoring program. Methods: Each hospital sampled six standardized sites in oncology pharmacies and six in outpatient clinics. Ultra-performance liquid chromatography coupled with tandem mass spectrometry was used for cyclophosphamide, docetaxel, doxorubicin, etoposide, 5-fluorouracil, gemcitabine, irinotecan, methotrexate, paclitaxel, and vinorelbine. Platinum-based drugs were analyzed by inductively coupled plasma mass spectrometry; this excludes inorganic platinum from the environment. Hospitals filled out an online questionnaire about their practices; a Kolmogorov–Smirnov test was used for some practices. Results: One hundred and twenty-four Canadian hospitals participated. Cyclophosphamide (405/1445, 28%), gemcitabine (347/1445, 24%), and platinum (71/756, 9%) were the most frequent. The 90th percentile of surface concentration was 0.01 ng/cm² for cyclophosphamide and 0.003 ng/cm² for gemcitabine. Centers that prepared 5000 or more antineoplastic per year had higher concentrations of cyclophosphamide and gemcitabine on their surfaces (p = 0.0001). Almost half maintained a hazardous drugs committee (46/119, 39%), but this did not influence the cyclophosphamide contamination (p = 0.051). Hazardous drugs training was more frequent for oncology pharmacy and nursing staff than for hygiene and sanitation staff. Conclusions: This monitoring program allowed centers to benchmark their contamination with pragmatic contamination thresholds derived from the Canadian 90th percentiles. Regular participation and local hazardous drug committee involvement provide an opportunity to review practices, identify risk areas, and refresh training. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Disponibilité de l'information médicale requise pour la déclaration d'une réaction indésirable médicamenteuse à Santé Canada : une étude exploratoire.
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Saint-Vil, Laurent, Jean-Baptiste, Thaïna-Rafi, Martel-Côté, Nicolas, Lebel, Denis, and Bussières, Jean-François
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PUBLIC health laws ,PHARMACOLOGY ,DOCUMENTATION ,DRUG side effects ,HUMAN services programs ,GOVERNMENT agencies ,MATERNAL & infant welfare ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,LONGITUDINAL method ,MEDICAL records ,RESEARCH ,RESEARCH methodology ,ELECTRONIC health records ,PUBLIC health ,COMPARATIVE studies ,TIME ,ACCESS to information - Abstract
Copyright of Canadian Journal of Hospital Pharmacy / Journal Canadien de la Pharmacie Hospitalière is the property of Canadian Society of Hospital Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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4. Canadian monitoring program of the surface contamination with 11 antineoplastic drugs in 122 centers.
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Delafoy, Clémence, Roussy, Claudine, Hudon, Anny-France, Cirtiu, Ciprian Mihai, Caron, Nicolas, Bussières, Jean-François, and Tanguay, Cynthia
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SPECIALTY hospitals ,ENVIRONMENTAL monitoring ,LIQUID chromatography ,MEDICAL equipment contamination ,ANTINEOPLASTIC agents ,OCCUPATIONAL exposure ,CANCER treatment ,HOSPITAL pharmacies ,GEMCITABINE ,MASS spectrometry ,DESCRIPTIVE statistics ,CYCLOPHOSPHAMIDE ,INDUSTRIAL hygiene ,OUTPATIENT services in hospitals - Abstract
Introduction: Occupational exposure to antineoplastic drugs can lead to long-term adverse effects on workers' health. Environmental monitoring is conducted once a year, as part of a Canadian monitoring program. The objective was to describe contamination with 11 antineoplastic drugs measured on surfaces. Methods: Six standardized sites in oncology pharmacy and six in outpatient clinic were sampled in each hospital. Samples were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry (non-platinum drugs) and by inductively coupled plasma mass spectrometry (platinum-based drugs). The limits of detection (in ng/cm
2 ) were: 0.0006 for cyclophosphamide; 0.001 for docetaxel; 0.04 for 5-fluorouracil; 0.0004 for gemcitabine; 0.0007 for irinotecan; 0.0009 for methotrexate; 0.004 for paclitaxel, 0.009 for vinorelbine, 0.02 for doxorubicine, 0.0037 for etoposide and 0.004 for the platinum. Sub-analyses were done with a Kolmogorov-Smirnov test Results: 122 Canadian hospitals participated. Cyclophosphamide (451/1412, 32% of positive samples, 90th percentile of concentration 0.0160 ng/cm2 ) and gemcitabine (320/1412, 23%, 0.0036 ng/cm2 ) were most frequently measured on surfaces. The surfaces most frequently contaminated with at least one drug were the front grille inside the biological safety cabinet (97/121, 80%) and the armrest of patient treatment chair (92/118, 78%).The distribution of cyclophosphamide concentration was higher for centers that prepared ≥ 5000 antineoplastic drug preparations/year (p < 0.0001). Conclusions: This monitoring program allowed centers to benchmark their contamination with pragmatic contamination thresholds derived from the Canadian 90th percentiles. Problematic areas need corrective measures such as decontamination. The program helps to increase the workers' awareness. [ABSTRACT FROM AUTHOR]- Published
- 2023
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5. Design and Development of an Escape Game as a Knowledge Transfer Tool in Preparation for an Accreditation Visit in a Health Care Facility.
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Chabrier, Amélie, Difabrizio, Aurélia, Parisien, Geneviève, Atkinson, Suzanne, and Bussières, Jean-François
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DRUG delivery systems ,ACCREDITATION ,HEALTH facilities ,RESEARCH methodology ,GAMES ,PATIENT satisfaction ,INTELLECT ,TRANSFER of training ,DESCRIPTIVE statistics ,COMMUNICATION ,LONGITUDINAL method - Abstract
Copyright of Canadian Journal of Hospital Pharmacy / Journal Canadien de la Pharmacie Hospitalière is the property of Canadian Society of Hospital Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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6. Surface contamination with nine antineoplastic drugs in 109 canadian centers; 10 years of a monitoring program.
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Chabut, Claire, Tanguay, Cynthia, Gagné, Sébastien, Caron, Nicolas, and Bussières, Jean-François
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SAFETY ,ENVIRONMENTAL monitoring ,INDUSTRIAL safety ,CROSS-sectional method ,LIQUID chromatography ,ANTINEOPLASTIC agents ,OCCUPATIONAL exposure ,IFOSFAMIDE ,IRINOTECAN ,FLUOROURACIL ,METHOTREXATE ,ANTIMETABOLITES ,DOCETAXEL ,CYCLOPHOSPHAMIDE ,DESCRIPTIVE statistics ,DRUG adulteration ,STERILIZATION (Disinfection) ,PACLITAXEL ,VINORELBINE ,COVID-19 pandemic - Abstract
Introduction: Healthcare workers exposure to antineoplastic drugs can lead to adverse health effects. Guidelines promote the safe handling of antineoplastic drugs, but no safe exposure limit was determined. Regular surface sampling contributes to ensuring workers safety. Methods: A cross-sectional monitoring is conducted once a year with voluntary Canadian centers, since 2010. Twelve standardized sampling sites were sampled. Samples were analyzed by high performance mass coupled liquid chromatography. The limits of detection (in ng/cm
2 ) were: 0.001 for cyclophosphamide and gemcitabine; 0.3 for docetaxel and ifosfamide; 0.04 for 5-fluorouracil and paclitaxel; 0.003 for irinotecan; 0.002 for methotrexate; 0.01 for vinorelbine. Results: The surfaces from 109 centers were sampled between 01/01/2020–18/06/2020. Twenty-six centers delayed their participation because of the COVID-19 pandemic. 1217 samples were analyzed. Surfaces were frequently contaminated with cyclophosphamide (34% positive, 75th percentile 0.00165 ng/cm2 ) and gemcitabine (16% and <0.001 ng/cm2 ). The armrest of patient treatment chairs (84% to at least one drug), the front grille inside the biological safety cabinet (BSC) (73%) and the floor in front of the BSC (55%) were frequently contaminated. Centers that prepared ≥5000 antineoplastic drugs annually had higher concentration of cyclophosphamide on their surfaces (p < 0.0001). Contamination measured on the surfaces was reduced from 2010 to 2020. Conclusions: This large-scale study showed reproducible long term follow up of the contamination of standardized sites of Canadian centers and a reduction in surface contamination from 2010 to 2020. Periodic surface sampling help centers meet their continuous improvements goals to reduce exposure as much as possible. The COVID-19 pandemic had a limited impact on the program. [ABSTRACT FROM AUTHOR]- Published
- 2022
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7. Quantification of healthcare workers' exposure to cyclophosphamide, ifosfamide, methotrexate, and 5-fluorouracil by 24-h urine assay: A descriptive pilot study.
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Palamini, Marie, Dufour, Annick, Therrien, Roxane, Delisle, Jean-François, Mercier, Geneviève, Gagné, Sébastien, Caron, Nicolas, and Bussières, Jean-François
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FLUOROURACIL ,HAZARDOUS substances ,LIQUID chromatography ,MASS spectrometry ,METABOLITES ,METHOTREXATE ,PERSONAL protective equipment ,RESEARCH funding ,URINATION ,URINALYSIS ,OCCUPATIONAL hazards ,PILOT projects ,ENVIRONMENTAL exposure ,DESCRIPTIVE statistics ,IFOSFAMIDE - Abstract
Purpose: The objective of this pilot study was to determine the frequency of urination and the concentration of four hazardous drugs (cyclophosphamide, ifosfamide, methotrexate, and fluorouracil) in workers' 24-h urine samples in relation to exposure to traces with hazardous drugs. Methods: The study was conducted in three healthcare centers in the region of Montréal, Quebec, Canada. We recruited healthcare workers (nurses and pharmacy technicians) assigned to the hematology-oncology department. Each participant was asked to collect all urine voided during a 24-h period, to fill out an activity journal documenting tasks performed and to document the use of personal protective equipment. Samples were analyzed for cyclophosphamide, ifosfamide, methotrexate, and alpha-fluoro-beta-alanine (FBAL, the main urinary metabolite of 5-fluorouracil). Drugs were quantified by ultra-performance liquid chromatography-tandem mass spectrometry (positive electrospray MRM mode). Results: Eighteen healthcare workers (10 nurses and 8 technicians) were recruited and provided consent to participate. Urine samples were obtained between 1 September and 30 September 2019. The number of urinations over the 24-h collection period ranged from 3 to 11 per participant. A total of 128 urine samples were analyzed for the 18 workers. All urine samples were negative for the four antineoplastics tested. Conclusion: No traces of cyclophosphamide, ifosfamide, methotrexate, or FBAL were found in the 24-h urine samples of 18 healthcare workers practicing in three healthcare facilities in Quebec. Although it was feasible to collect 24-h urine samples in this research project, it appears unrealistic to do so recurrently as part of a large-scale surveillance program. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Cross-sectional evaluation of surface contamination with 9 antineoplastic drugs in 93 Canadian healthcare centers: 2019 results.
- Author
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Palamini, Marie, Gagné, Sébastien, Caron, Nicolas, and Bussières, Jean-François
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ANTIMETABOLITES ,ANTINEOPLASTIC agents ,CLINICS ,ENVIRONMENTAL monitoring ,HEALTH facilities ,LIQUID chromatography ,MASS spectrometry ,PHARMACOLOGY ,STATISTICS ,DATA analysis ,EQUIPMENT & supplies ,CYCLOPHOSPHAMIDE ,DESCRIPTIVE statistics ,MEDICAL equipment contamination - Abstract
Introduction: The primary objective was to describe environmental contamination with National Institute for Occupational Safety and Health Group 1 hazardous drugs in oncology pharmacies and outpatient clinics in Canada in 2019, as part of an annual surveillance project. Methods: In each participating center, 12 standardized sites (6 in the oncology pharmacy and 6 in outpatient clinic) were sampled. Each sample was prepared to allow quantification of six antineoplastic drugs (cyclophosphamide, ifosfamide, methotrexate, gemcitabine, 5-fluorouracil, and irinotecan) by ultra-performance liquid chromatography-tandem mass spectrometry. Samples were also tested for three additional antineoplastic drugs (docetaxel, paclitaxel, and vinorelbine) without quantification. The impact of certain characteristics of the sampling sites was evaluated with a Kolmogorov–Smirnov test for independent samples. Results: Ninety-three Canadian centers participated in 2019, with a total of 1045 surfaces sampled. Cyclophosphamide was the drug most often found in the surface samples (32.4% of samples with positive result), followed by gemcitabine (20.3%). The front grille inside the biological safety cabinet (81.5% of samples positive for at least one antineoplastic drug) and the armrest of a treatment chair (75.8%) were the most frequently contaminated surfaces. Centers with more oncology inpatient and outpatient beds, those that prepared more antineoplastic drugs each year, and those that used more cyclophosphamide each year had higher concentrations of cyclophosphamide contamination on the surfaces tested (p < 0.0001). Conclusion: Traces of dangerous drugs were found in oncology pharmacies and oncology outpatient clinics in 93 Canadian hospitals in 2019. However, the quantities measured were very small. Every healthcare worker should consider these work areas to be contaminated and should wear appropriate protective equipment. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Multicenter study of environmental contamination with cyclophosphamide, ifosfamide, and methotrexate in 48 Canadian hospitals.
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Poupeau, Céline, Tanguay, Cynthia, Caron, Nicolas J., and Bussières, Jean-François
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POLLUTION ,ANTINEOPLASTIC agents ,ENVIRONMENTAL monitoring ,LIQUID chromatography ,MASS spectrometry ,RESEARCH methodology ,MEDICAL cooperation ,METHOTREXATE ,NONPARAMETRIC statistics ,RESEARCH ,CYCLOPHOSPHAMIDE ,DESCRIPTIVE statistics ,IFOSFAMIDE - Abstract
Context Oncology workers are occupationally exposed to antineoplastic drugs. This exposure can induce adverse health effects. In order to reduce their exposure, contamination on surfaces should be kept as low as possible. Objectives To monitor environmental contamination with cyclophosphamide, ifosfamide, and methotrexate in oncology pharmacy and patient care areas in Canadian hospitals. To describe the impact of some factors that may limit contamination. Methods This is a descriptive study. Twelve standardized sites were sampled in each participating center (six in the pharmacy and six in patient care areas). Samples were analyzed for the presence of cyclophosphamide, ifosfamide, and methotrexate by ultra-performance liquid chromatography tandem mass spectrometry technology. Descriptive statistical analyses were done and results were compared with a Kolmogorov–Smirnov test for independent samples. Results In 2015, 48 hospitals participated in this study (48/202, 24%). Overall, 34% (181/525) of the samples were positive for cyclophosphamide, 8% (41/525) for ifosfamide, and 6% (31/525) for methotrexate. The 75th percentile value of cyclophosphamide surface concentration was 6.9 pg/cm
2 . For ifosfamide and methotrexate, they were lower than the limit of detection. Centers who prepared more antineoplastic drugs per year and centers who used more cyclophosphamide per year showed significantly higher surface contamination (p < 0.0001). Over the years, we observed a reduction in surface contamination. Conclusion In comparison with other multicenter studies that were conducted in Canada, the concentration of antineoplastic drugs measured on surfaces is decreasing. Regular environmental monitoring is a good practice in order to maintain contamination as low as reasonably achievable. [ABSTRACT FROM AUTHOR]- Published
- 2018
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10. Self-administered medications in the postpartum wards: A study on satisfaction and perceptions.
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Schérer, Hugo, Bernier, Emmy, Rivard, Julie, Yu, Lavina, Duchesne‐Côté, Guillaume, Lebel, Denis, Bussières, Jean‐François, and Ferreira, Ema
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ANALGESICS ,BREASTFEEDING ,DRUG side effects ,LONGITUDINAL method ,RESEARCH methodology ,OBSTETRICS ,PAIN ,PATIENT satisfaction ,PATIENTS ,POSTNATAL care ,PROBABILITY theory ,QUESTIONNAIRES ,SELF medication ,PATIENTS' attitudes ,DESCRIPTIVE statistics - Abstract
Objective The objective of this study was to describe women's satisfaction and perceptions on the postpartum self-administered medication (SAM) program at our institution and on pain relief. Also, we aimed at describing maternal and breastfed infants' adverse events with the use of the postpartum SAM program. Method This prospective 1-group mixed methods survey conducted in a mother-and-child tertiary center included women enrolled in the postpartum SAM program who had a live newborn, understood French or English, and were at least 18 years old. Newborns included cohabited with their mother during their hospitalization and had received breast milk at least once. Data were collected through direct interviews using a questionnaire and through medical charts. Results We included 314 mothers and 263 breastfed newborns in the study. Ninety-seven percent of all users appreciated the SAM. The self-reported median overall improvement of pain was 80% (interquartile range, 70%-90%). However, 18% of users who delivered vaginally and 32% who delivered through caesarean would have preferred traditional drug dispensing by the nurse ( P = .009). Drugs used in the SAM program were generally well tolerated. There were no worrisome adverse drug events reported in newborns' medical charts. Conclusion Results show a 97% rate of satisfaction of the SAM program and a high self-reported pain improvement in a cohort of 314 women using our SAM program. The results suggest that the SAM program should remain a standard practice in our institution. Some recommendations will be drawn to better tailor the SAM program to the needs expressed by the users. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Unlicensed and off-label drug use in paediatrics in a mother-child tertiary care hospital.
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Corny, Jennifer, Bailey, Benoit, Lebel, Denis, and Bussières, Jean-François
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CHILDREN'S hospitals ,MEDICAL prescriptions ,OFF-label use (Drugs) ,CROSS-sectional method ,DESCRIPTIVE statistics ,DRUG administration ,DRUG dosage - Abstract
Copyright of Paediatrics & Child Health (1205-7088) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2016
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12. Impact and appreciation of two methods aiming at reducing hazardous drug environmental contamination: The centralization of the priming of IV tubing in the pharmacy and use of a closed-system transfer device.
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Guillemette, Annie, Langlois, Hélène, Voisine, Maxime, Merger, Delphine, Therrien, Roxane, Mercier, Genevieve, Lebel, Denis, and Bussières, Jean-François
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ATTITUDE testing ,CHI-squared test ,CHILDREN'S hospitals ,COMPARATIVE studies ,DRUG adulteration ,HIGH performance liquid chromatography ,LONGITUDINAL method ,MASS spectrometry ,PHARMACY technicians ,QUESTIONNAIRES ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Objectives: The main objective was to evaluate the impact of two methods aiming at reducing hazardous drug environmental contamination: the centralization of the priming of IV tubing in the pharmacy and the use of a closed-system transfer device. The secondary objective was to evaluate the satisfaction of pharmacy technicians using a survey. Methods: Sites in the hematology-oncology satellite pharmacy and care unit were analyzed for the presence of cyclophosphamide, ifosfamide and methotrexate before and after the centralization of the priming of IV tubing in the pharmacy and before and after using a closed-system transfer device. The limits of detection for cyclophosphamide, ifosfamide and methotrexate were, respectively, of 0.0015 ng/cm
2 , 0.0012 ng/cm2 and 0.0060 ng/cm2 . The pharmacy technician satisfaction was evaluated using a questionnaire. Results: A total of 225 samples was quantified. After the centralization of priming in the pharmacy, no significant difference was found in the proportion of positive samples for cyclophosphamide, ifosfamide and methotrexate. Traces of cyclophosphamide found on the floor in patient care areas was significantly reduced (median[min-max] 0.08[0.06−0.09]ng/cm2 vs. 0.03[0.02−0.05], p < 0.0001). After using a closed-system transfer device, a significant difference was found for the proportion of cyclophosphamide positive samples (15/45(33%) vs. 0/45(0%), p < 0.0001), but no significant difference was found for ifosfamide (12/45(27%) vs. 5/45(11%), p = 0.059) and methotrexate (1/45(2%) vs. 2/45(4%), p = 0.557). Pharmacy technicians raised issues following the centralization of priming (e.g. workload) and the use of closed-system transfer devices (e.g. spills, particles, workload and handling difficulties). Conclusion: The centralization of the priming of IV tubing in the pharmacy reduced floor contamination in patient care areas without increasing surface contamination in the pharmacy. Closed-system transfer devices reduced contamination in pharmacy, but handling issues were raised by pharmacy technicians. [ABSTRACT FROM AUTHOR]- Published
- 2014
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13. Pilot Study on the Impact of Evidence-Based Data on Oncology Pharmacists’ Perceptions.
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Renet, Sophie, Lebel, Denis, Prot-Labarthe, Sonia, Therrien, Roxane, Bourdon, Olivier, and Bussières, Jean-François
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FISHER exact test ,HOSPITAL pharmacies ,RESEARCH methodology ,ONCOLOGY ,PHARMACISTS ,QUESTIONNAIRES ,RESEARCH funding ,STATISTICAL sampling ,SCALE analysis (Psychology) ,EVIDENCE-based medicine ,PILOT projects ,PROFESSIONAL practice ,PRE-tests & post-tests ,CROSS-sectional method ,DESCRIPTIVE statistics ,ATTITUDE (Psychology) - Abstract
The article presents a study to evaluate the impact of evidence-based data on perceptions of oncology pharmacists and on factors that contributed to evolution of oncology pharmacy practice. The study concludes that high importance was given to factors related to pharmacists' perception on patient safety, health care costs in comparison to use of evidence-based data.
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- 2014
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14. Nursing Perception of the Impact of Automated Dispensing Cabinets on Patient Safety and Ergonomics in a Teaching Health Care Center.
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Rochais, Élise, Atkinson, Suzanne, Guilbeault, Mélanie, and Bussières, Jean-François
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AUTOMATION ,DRUG delivery systems ,ACADEMIC medical centers ,FOCUS groups ,ERGONOMICS ,INTERVIEWING ,RESEARCH methodology ,NURSES' attitudes ,PATIENT safety ,QUESTIONNAIRES ,SCALE analysis (Psychology) ,THEMATIC analysis ,CROSS-sectional method ,DESCRIPTIVE statistics ,EVALUATION - Abstract
The article discusses the study on the evaluation of nursing staff's feeling regarding the effect of automated dispensing cabinets (ADCs) safe delivery of healthcare ergonomics. Topics discussed include the use of questionnaire for the evaluation, response of the nurses regarding the use of ADCs, non satisfaction of additional delays in administration and preparation of medication dose.
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- 2014
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15. Pre-Post Pilot Study of Noise Levels at a University Hospital Center Pharmacy Department.
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Guérin, Aurélie, Leroux, Tony, and Bussières, Jean-François
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ACADEMIC medical centers ,HEALTH facilities ,HOSPITAL pharmacies ,NOISE ,SCIENTIFIC observation ,T-test (Statistics) ,TIME ,PILOT projects ,PRE-tests & post-tests ,CROSS-sectional method ,DESCRIPTIVE statistics - Published
- 2013
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16. Prioritizing Pharmaceutical Activities: A Simulation by Pharmacy Residents.
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Renet, Sophie, Tanguay, Cynthia, Hall, Kevin, and Bussières, Jean-François
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DECISION making ,HOSPITAL pharmacies ,HOSPITAL medical staff ,PHARMACISTS ,PHARMACY education ,TIME management ,TEAMS in the workplace ,DATA analysis software ,DESCRIPTIVE statistics - Published
- 2013
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17. Nursing Perception of the Impact of Medication Carts on Patient Safety and Ergonomics in a Teaching Health Care Center.
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Rochais, Élise, Atkinson, Suzanne, and Bussières, Jean-François
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DRUG delivery systems ,ACADEMIC medical centers ,FOCUS groups ,ERGONOMICS ,INTERVIEWING ,JOB satisfaction ,RESEARCH methodology ,NURSES ,NURSES' attitudes ,SCIENTIFIC observation ,PATIENT safety ,SENSORY perception ,PHARMACISTS ,QUESTIONNAIRES ,SCALE analysis (Psychology) ,THEMATIC analysis ,HUMAN services programs ,CROSS-sectional method ,DESCRIPTIVE statistics - Published
- 2013
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18. Training workload in the investigational drug service of a university hospital center.
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Martel-Côté, Nicolas, Choquette, Rachel, Côté-Sergerie, Catherine, Lebel, Denis, Bussières, Jean-François, and Tanguay, Cynthia
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CLINICAL trials , *ACADEMIC medical centers , *ANALYSIS of variance , *TIME , *RESEARCH methodology , *INVESTIGATIONAL drugs , *RETROSPECTIVE studies , *HOSPITAL pharmacies , *EMPLOYEES' workload , *DESCRIPTIVE statistics , *QUESTIONNAIRES , *HEALTH care rationing , *READING - Abstract
Purpose Training represents a considerable portion of research activities and is vastly different for each clinical trial. This variation is partially explained by the lack of detailed regulations surrounding training procedures, which hinders the ability of investigational drug service (IDS) staff to plan their workload. The aim of this study was to quantify the workload associated with trial-specific training of IDS staff. The secondary aim was to identify the factors associated with training complexity. Methods A retrospective study was carried out in the IDS of a mother and child university hospital. Trial-specific documents on which the pharmacy staff was trained were analyzed. Workload was calculated by measuring reading time. The readability of each document was determined by the Flesch Reading Ease score. The complexity of the trials was established using the scoring method of Calvin-Lamas et al. The influence of the following factors on training was assessed by analysis of variance: sponsor type, research phase, and research focus by medical specialty. Results A total of 93 clinical trials and 433 documents were included. Investigator's brochures were the longest (a mean [SD] of 107 [46] pages; P < 0.0001) and most difficult documents to read (mean [SD] readability score, 25.5 [4.4]; P < 0.0001). Trials with industry sponsors required a significantly longer overall reading time (mean [SD], 12.26 [6.72] hours; P < 0.0001). On average, a mean (SD) of 9.42 (7.16) hours of reading were necessary to train one employee for a clinical trial. Conclusion This study is the first to document reading time necessary for training of IDS staff. The training workload varied by sponsor type, while the research phase and medical specialty had little impact. IDS units would benefit from a tool that could identify complex trials. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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