1. Application of the FreeStyle®Libre Glucose Monitoring System in type 1 diabetes mellitus patients aged 1–4 years.
- Author
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Li, Yangshiyu, Cao, Bingyan, Chen, Qiong, Du, Mengmeng, Yan, Mingming, Chen, Yongxing, Wei, Haiyan, Wu, Xue, Cui, Yan, and Liu, Fang
- Subjects
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CONSENSUS (Social sciences) , *THERAPEUTICS , *BLOOD sugar monitoring , *ATTITUDE (Psychology) , *TYPE 1 diabetes , *SATISFACTION , *REGRESSION analysis , *FAMILY attitudes , *DESCRIPTIVE statistics , *HEALTH attitudes , *PATIENT safety , *HOSPITAL care of children , *CHILDREN - Abstract
Background: To investigate the analytical accuracy, safety performance, and user satisfaction (guardians of study participants) of the FreeStyle®Libre Glucose Monitoring System in the treatment of type 1 diabetes mellitus (T1DM), in children aged <4 years. Methods: Sixteen hospitalized children with new onset T1DM, aged 4 months to 4 years, were enrolled in this study. Patients wore the sensor for 14 days; sensor scans were performed immediately and at 5, 10, and 15 min after capillary blood glucose (BG) measurements to evaluate the effectiveness of the device and the lag effect. Results: The consensus error grid showed that 96.40% of values fell within zone A (no clinical impact) and 3.60% within zone B (little/no clinical impact). Overall, the mean absolute relative difference (MARD) was 9.34%, and was higher in the capillary BG <4.0 mmol/L group (15.18%) than in the 4–10 mmol/L (9.63%) and >10 mmol/L (7.17%) groups. The MARD increased gradually with scanning time extension, indicating a short lag effect. Regression analysis showed that a higher BG level was associated with a greater difference in FreeStyle®Libre System measurements. Conclusions: The use of the FreeStyle®Libre System in children aged 1–4 years is accurate and safe, and may be accurate down to 4 months, independent of patient characteristics. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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