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Your search keyword '"Judith M, Silverman"' showing total 13 results
Start Over Author "Judith M, Silverman" Topic developmental neuroscience
13 results on '"Judith M, Silverman"'

1. Cerebrovascular amyloid angiopathy in bioengineered vessels is reduced by high‐density lipoprotein particles enriched in apolipoprotein E

Author

Emma M. Martin, Jerome Robert, Zoe Gidden, Tara M. Caffrey, Neil R. Cashman, Andrew Agbay, Guilaine K. Boyce, Luke McAlary, Amanda Clark, Cheryl L. Wellington, Emily B. Button, Judith M. Silverman, and Megan Gilmore

Subjects
Apolipoprotein E, Pathology, medicine.medical_specialty, Amyloid, Epidemiology, Health Policy, Cerebrovascular amyloid, medicine.disease, Angiopathy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, High-density lipoprotein, Developmental Neuroscience, chemistry, medicine, Neurology (clinical), Geriatrics and Gerontology, Analysis method
Published
2020
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2. O5‐06‐01: SELECTIVE TARGETING OF AMYLOID‐BETA OLIGOMER SPECIES BY PMN310, A MONOCLONAL ANTIBODY RATIONALLY DESIGNED FOR GREATER THERAPEUTIC POTENCY IN ALZHEIMER'S DISEASE

Author

Jing Wang, Steven S. Plotkin, Beibei Zhao, Neil R. Cashman, Ebrima Gibbs, Judith M. Silverman, Xubiao Peng, and Johanne Kaplan

Subjects
Epidemiology, medicine.drug_class, Chemistry, Health Policy, Disease, Pharmacology, Monoclonal antibody, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Potency, Neurology (clinical), Amyloid beta oligomer, Geriatrics and Gerontology
Published
2019
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3. P2‐048: HUMANIZED PMN310 SHOWS ENHANCED THERAPEUTIC POTENTIAL BY BINDING TOXIC LOW MOLECULAR WEIGHT Aβ OLIGOMERS WHILE AVOIDING ARIA‐RELATED BINDING TO Aβ DEPOSITS IN AD PATIENT BRAINS

Author

Judith M. Silverman, Jing Wang, Xubiao Peng, Johanne Kaplan, Ebrima Gibbs, Neil R. Cashman, and Steven S. Plotkin

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Aβ oligomers, Biophysics, Neurology (clinical), Geriatrics and Gerontology
Published
2018
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4. [P3–182]: PROPAGATIVE TOXIC Aβ OLIGOMER SUBCLASS IDENTIFIED AND DEFINED BY SOLVENT ORIENTATION OF THE LYSINE 28 SIDE CHAIN

Author

Xubiao Peng, Judith M. Silverman, Jing Wang, Claudia Balducci, Kristina Martens, Ebrima Gibbs, Neil R. Cashman, Ging-Yuek Robin Hsiung, Gianluigi Forloni, Steven S. Plotkin, Cheryl L. Wellington, Catherine M. Cowan, and Masoud Yousefi

Subjects
Epidemiology, Stereochemistry, Health Policy, Lysine, Orientation (graph theory), Oligomer, Subclass, Solvent, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, Biochemistry, Side chain, Neurology (clinical), Geriatrics and Gerontology
Published
2017
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5. P3‐047: The Amyloid‐Beta (Aβ) Oligomer‐Specific CYCLIC‐SER‐ASN‐LYS (CSNK) Tripeptide is Highly Immunogenic and Induces Sustained Levels of ANTI‐CSNK Antibodies of the IGG1 Subclass

Author

Ebrima Gibbs, Cheryl L. Wellington, Judith M. Silverman, and Neil R. Cashman

Subjects
biology, Epidemiology, Amyloid beta, Health Policy, Tripeptide, Oligomer, Molecular biology, Subclass, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Antibody
Published
2016
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6. P4‐400: Novel Amyloid‐β Oligomer‐Specific Epitopes: a Hypothesis Driven Approach to Alzheimer's Immunotherapeutics

Author

Steve Plotkin, Ebrima Gibbs, Neil R. Cashman, Xubiao Peng, Judith M. Silverman, and Jing Wang

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, Biochemistry, Amyloid β, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Oligomer, Epitope
Published
2016
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7. P4‐299: A Computational Method to Predict Disease‐Specific Epitopes in Aβ, and its Application to Oligomer‐Selective Antibodies for Alzheimer’S Immunotherapy

Author

Xubiao Peng, Judith M. Silverman, Neil R. Cashman, and Steven S. Plotkin

Subjects
0301 basic medicine, Disease specific, biology, Epidemiology, Chemistry, Health Policy, medicine.medical_treatment, Immunotherapy, Oligomer, Epitope, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 030104 developmental biology, Developmental Neuroscience, Immunology, biology.protein, medicine, Neurology (clinical), Geriatrics and Gerontology, Antibody
Published
2016
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8. P4‐314: Epitope‐specific amyloid‐β oligomer vaccination ameliorates amygdala‐dependent memory deficits and inhibits region‐to‐region spread of plaque pathology in APP/PS1 mice

Author

Ebrima Gibbs, Masoud Yousefi, Laura Saward, Xiaobing Han, Jing Wang, Cory Nykiforuk, Cheryl L. Wellington, Kristina Martens, Judith M. Silverman, and Neil R. Cashman

Subjects
Amyloid β, Epidemiology, business.industry, Health Policy, Oligomer, Amygdala, Epitope, Vaccination, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine.anatomical_structure, Developmental Neuroscience, chemistry, Immunology, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2015
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9. O4‐04‐01: Characterization of a humanized amyloid beta oligomer monoclonal antibody (5E3) under preclinical development for passive immunotherapy of Alzheimer's disease

Author

Brian Dupas, Neil R. Cashman, Shantha Kodihalli, Melanie Leonhardt, Bryce Hrehorak, Peter Cheung, Andrew L. Goertzen, Judith M. Silverman, Darrell Johnstone, Ross Reid, Harmoni Hoffman, Laura Saward, John Merluza, Ebrima Gibbs, Michael F. Jackson, Xiaobing Han, and Cory Nykiforuk

Subjects
Epidemiology, business.industry, medicine.drug_class, Health Policy, Passive Immunotherapy, Disease, Monoclonal antibody, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cancer research, Medicine, Neurology (clinical), Amyloid beta oligomer, Geriatrics and Gerontology, business
Published
2015
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10. O1‐05‐04: An amyloid‐beta oligomer epitope specific for toxic assemblages in Alzheimer's disease

Author

Ging-Yuek Robin Hsiung, Guillaume Lamour, Claudia Balducci, Judith M. Silverman, Cheryl L. Wellington, Ebrima Gibbs, Catherine M. Cowan, Laura Saward, Gianluigi Forloni, and Neil R. Cashman

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Disease, Amyloid beta oligomer, Geriatrics and Gerontology, Molecular biology, Epitope
Published
2015
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11. P4‐371: PRECLINICAL DEVELOPMENT OF AN AMYLOID‐B OLIGMER (ABO) SPECIFIC MONOCLONAL ANTIBODY (5E3) FOR POTENTIAL PASSIVE IMMUNOTHERAPY OF ALZHEIMER'S DISEASE

Author

Andrew Emanuel, Laura Saward, Judith M. Silverman, Cheryl L. Wellington, Darrell Johnstone, Peter Cheung, Shantha Kodihalli, Andrea Masi, Cory Nykiforuk, Robyn Cassan, Xiaobing Han, Neil R. Cashman, and Ebrima Gibbs

Subjects
Amyloid, Epidemiology, medicine.drug_class, business.industry, Health Policy, Passive Immunotherapy, Disease, Monoclonal antibody, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, ABO blood group system, Immunology, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2014
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12. P4–289: Normal healthy donors possess plasma IgG reactive to a neutralizing epitope for toxic and amyloid‐seeding beta‐amyloid oligomers

Author

Laura Saward, Jing Wang, Hui Chen, Marni D. Uger, Valeriy G. Ostapchenko, Weihong Song, Neil R. Cashman, Andrea Masi, Claudia Balducci, Judith M. Silverman, Marco A. M. Prado, Gianluigi Forloni, Ebrima Gibbs, and Cheryl L. Wellington

Subjects
chemistry.chemical_classification, Epidemiology, Health Policy, Mutant, Wild type, Peptide, Molecular biology, Neutralizing epitope, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Enzyme, Developmental Neuroscience, chemistry, Desolvation, Secretion, Neurology (clinical), Geriatrics and Gerontology
Abstract

Computational chemistry methods have been applied to investigate the observed decrease in affinity.Results:As expected, the Swedishmutation peptide showed the highest maximum velocity, while the KM value was comparable to that for the wild-type substrate. The A673T mutation substrate yielded a Vmax value in the same range as the wild-type, but the KM value was increased by 50 fold. These results suggest the turnover rate of the enzyme-peptide complex is not affected by the mutation on the peptide. However, interpreting KM as a surrogate for affinity, the mutation reduces the affinity of the substrate for the enzyme. Preliminary modelingresults indicate that suboptimal interaction between BACE and the T673 hydroxyl group, which do not offset its increase desolvation, might be one of the reasons affecting the free energy of binding of the mutant. We also confirmed previous observations that in cells overexpressing APPA673T, soluble APP beta (sAPPb) secretion, primary product of BACE1 cleavage, is reduced by 50% compared to cells overexpressing the wild type construct. Conclusions: Taken together, this data suggest that a reduction of BACE affinity for this mutated APP explains how it may protect against Alzheimer’s disease. Thus providing strong evidence that reducing BACE activity by inhibitors may be beneficial for the treatment of AD.

Published
2013
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13. O4‐06‐03: An immunological epitope specific for toxic oligomeric Aß in Alzheimer's disease

Author

Judith M. Silverman, Xavier Roucou, Weihong Song, Jean-Philippe Deslys, Katarina Grznarova, Cheryl L. Wellington, Human Rezaei, Ebrima Gibbs, Neil R. Cashman, Ging-Yuek Robin Hsiung, and Will Guest

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Neurology (clinical), Disease, Geriatrics and Gerontology, Virology, Epitope
Published
2012
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