8 results on '"Longmore, Danielle K"'
Search Results
2. Association between hyperglycaemia in pregnancy and growth of offspring in early childhood: The PANDORA study.
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Titmuss, Angela, Longmore, Danielle K., Barzi, Federica, Barr, Elizabeth L. M., Webster, Vanya, Wood, Anna, Simmonds, Alison, Brown, Alex D. H., Connors, Christine, Boyle, Jacqueline A., Oats, Jeremy, McIntyre, H. David, Shaw, Jonathan E., Craig, Maria E., and Maple‐Brown, Louise J.
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RISK of childhood obesity , *HUMAN growth , *STATURE , *HYPERGLYCEMIA , *BODY weight , *CONFIDENCE intervals , *CHILD development , *RESEARCH methodology , *REGRESSION analysis , *PRENATAL exposure delayed effects , *TYPE 2 diabetes , *RISK assessment , *COMPARATIVE studies , *DESCRIPTIVE statistics , *GESTATIONAL diabetes , *BODY mass index , *ABORIGINAL Australians , *LONGITUDINAL method , *DISEASE complications , *PREGNANCY - Abstract
Summary: Background: Few studies have assessed whether children exposed to in utero hyperglycaemia experience different growth trajectories compared to unexposed children. Objectives: To assess association of type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) with early childhood weight, length/height and body mass index (BMI) trajectories, and with timing and magnitude of peak BMI in infancy. Methods: PANDORA is a birth cohort recruited from an Australian hyperglycaemia in pregnancy register, and women with normoglycaemia recruited from the community. Offspring growth measures were obtained from health records over a median follow‐up of 3.0 years (interquartile range 1.9–4.0). This analysis included children born to Aboriginal mothers with in utero normoglycaemia (n = 95), GDM (n = 228) or T2D (n = 131). Growth trajectories (weight, length/height and BMI) were estimated using linear mixed models with cubic spline functions of child age. Results: After adjustment for maternal factors (age, BMI, parity, smoking, and socioeconomic measures) and child factors (age, gestational age at birth, and sex), children born to mothers with T2D or GDM had lower weight, length/height and BMI trajectories in infancy than children born to mothers with normoglycaemia, but similar weight and BMI by completion of follow‐up. Children exposed to T2D had lower mean peak BMI 17.6 kg/m2 (95% confidence interval [CI] 17.3–18.0) than children exposed to normoglycaemia (18.6 kg/m2 [18.1–18.9]) (p = 0.001). Conclusions: Maternal hyperglycaemia was associated with differences in early childhood growth trajectories after adjustment for maternal BMI. Exploration of associations between in utero hyperglycaemia exposure and growth trajectories into later childhood is required. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Diabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospital Severity of COVID-19: An International, Multicenter Retrospective Meta-analysis.
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Longmore, Danielle K., Miller, Jessica E., Bekkering, Siroon, Saner, Christoph, Mifsud, Edin, Zhu, Yanshan, Saffery, Richard, Nichol, Alistair, Colditz, Graham, Short, Kirsty R., Burgner, David P., Anfasa, F., Benfield, T.L., Blaauw, M.J.T., Boonman-de Winter, L.J.M., Brucato, A.L., Buanes, E.A., Burhan, E., Calabro, E., and Ceschi, A.
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COVID-19 , *OBESITY , *ADULTS , *DIABETES , *HOSPITAL mortality - Abstract
Objective: Obesity is an established risk factor for severe coronavirus disease 2019 (COVID-19), but the contribution of overweight and/or diabetes remains unclear. In a multicenter, international study, we investigated if overweight, obesity, and diabetes were independently associated with COVID-19 severity and whether the BMI-associated risk was increased among those with diabetes.Research Design and Methods: We retrospectively extracted data from health care records and regional databases of hospitalized adult patients with COVID-19 from 18 sites in 11 countries. We used standardized definitions and analyses to generate site-specific estimates, modeling the odds of each outcome (supplemental oxygen/noninvasive ventilatory support, invasive mechanical ventilatory support, and in-hospital mortality) by BMI category (reference, overweight, obese), adjusting for age, sex, and prespecified comorbidities. Subgroup analysis was performed on patients with preexisting diabetes. Site-specific estimates were combined in a meta-analysis.Results: Among 7,244 patients (65.6% overweight/obese), those with overweight were more likely to require oxygen/noninvasive ventilatory support (random effects adjusted odds ratio [aOR], 1.44; 95% CI 1.15-1.80) and invasive mechanical ventilatory support (aOR, 1.22; 95% CI 1.03-1.46). There was no association between overweight and in-hospital mortality (aOR, 0.88; 95% CI 0.74-1.04). Similar effects were observed in patients with obesity or diabetes. In the subgroup analysis, the aOR for any outcome was not additionally increased in those with diabetes and overweight or obesity.Conclusions: In adults hospitalized with COVID-19, overweight, obesity, and diabetes were associated with increased odds of requiring respiratory support but were not associated with death. In patients with diabetes, the odds of severe COVID-19 were not increased above the BMI-associated risk. [ABSTRACT FROM AUTHOR]- Published
- 2021
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4. Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort.
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Longmore, Danielle K., Barr, Elizabeth L.M., Barzi, Federica, Lee, I-Lynn, Kirkwood, Marie, Connors, Christine, Boyle, Jacqueline, O'Dea, Kerin, Zimmet, Paul, Oats, Jeremy, Catalano, Patrick, McIntyre, H. David, Brown, Alex D.H., Shaw, Jonathan E., Maple-Brown, Louise J., and PANDORA study research team
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ECONOMIC impact , *LEAN body mass , *SOCIAL factors , *GESTATIONAL diabetes , *OBESITY , *OBESITY complications , *ADIPOSE tissue physiology , *HYPERGLYCEMIA , *NEWBORN infants , *PRENATAL exposure delayed effects , *TYPE 2 diabetes , *MOTHERHOOD , *PARENTING , *SOCIOECONOMIC factors , *PREGNANCY outcomes , *BIRTH weight , *SMOKING , *BODY mass index , *INDIGENOUS peoples , *ADIPOSE tissues , *LONGITUDINAL method , *DISEASE complications - Abstract
Background: Australian Indigenous women experience high rates of social disadvantage and type 2 diabetes (T2D) in pregnancy, but it is not known how social factors and maternal behaviours impact neonatal adiposity in offspring of women with hyperglycaemia in pregnancy.Methods: Participants were Indigenous (n = 404) and Europid (n = 240) women with gestational diabetes mellitus (GDM) or T2D in pregnancy and their offspring in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. Social, economic factors, and maternal behaviours were measured in pregnancy and six neonatal anthropometric outcomes were examined after birth.Results: On univariate analysis, maternal education < 12 years (p = 0.03), unemployment (p = 0.001), welfare income vs no welfare income (p = 0.001), lower area based socio-economic score (p < 0.001), and fast food intake > 2 times/week (p = 0.002) were associated with increased sum of skinfolds (SSF) in offspring. Smoking was significantly associated with a reduction in anthropometric measures, except SSF. In multivariable models adjusted for ethnicity, BMI and hyperglycaemia, social and economic factors were no longer significant predictors of neonatal outcomes. Smoking was independently associated with a reduction in length, head circumference and fat free mass. Frequent fast food intake remained independently associated with SSF (β-coefficient 1.08 mm, p = 0.02).Conclusion: In women with hyperglycaemia in pregnancy, social factors were associated with neonatal adiposity, particularly skinfold measures. Promoting smoking cessation and limited intake of energy-dense, nutrient-poor foods in pregnancy are important to improve neonatal adiposity and lean mass outcomes. Addressing inequities in social and economic factors are likely to be important, particularly for Indigenous women or women experiencing social disadvantage. [ABSTRACT FROM AUTHOR]- Published
- 2020
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5. Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study.
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Lee, I‐Lynn, Barzi, Federica, Kirkwood, Marie, Hampton, Vanya, Graham, Sian, O'Dea, Kerin, Longmore, Danielle K., Barr, Elizabeth L.M., Whitbread, Cherie, Maple‐Brown, Louise J., Van Dokkum, Paula, Oats, Jeremy, McIntyre, H. David, Shaw, Jonathan E., Connors, Christine, Boyle, Jacqueline A., Catalano, Patrick, and Brown, Alex D.H.
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HYPERGLYCEMIA ,ADIPOSE tissues ,CEPHALOMETRY ,CHILD health services ,GESTATIONAL diabetes ,ETHNIC groups ,GESTATIONAL age ,INDIGENOUS peoples ,LONGITUDINAL method ,MATERNAL age ,MATHEMATICAL models ,MULTIVARIATE analysis ,TYPE 2 diabetes ,WEIGHT gain in pregnancy ,SMOKING ,THEORY ,EDUCATIONAL attainment ,BODY mass index ,PARITY (Obstetrics) ,CHILDREN ,DISEASE risk factors - Abstract
Summary: Background: In‐utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity. [ABSTRACT FROM AUTHOR]
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- 2019
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6. Corrigendum to "Type 2 diabetes after a pregnancy with gestational diabetes among first nations women in Australia: The PANDORA study" [Diabetes Res. Clin. Pract. 181 (2021) 109092].
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Wood, Anna J., Boyle, Jacqueline A., Barr, Elizabeth L.M., Barzi, Federica, Hare, Matthew J.L., Titmuss, Angela, Longmore, Danielle K., Death, Elizabeth, Kelaart, Joanna, Kirkwood, Marie, Graham, Sian, Connors, Christine, Moore, Elizabeth, O'Dea, Kerin, Oats, Jeremy J.N., McIntyre, Harold D., Zimmet, Paul Z., Lu, Zhong X., Brown, Alex, and Shaw, Jonathan E.
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INDIGENOUS Australians , *GESTATIONAL diabetes , *TYPE 2 diabetes , *DIABETES - Published
- 2024
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7. Associations of gestational diabetes and type 2 diabetes during pregnancy with breastfeeding at hospital discharge and up to 6 months: the PANDORA study
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Paul Zimmet, Eyvette Hawthorne, Elizabeth L M Barr, Kerin O'Dea, Jeremy Oats, Marie Kirkwood, Harold David McIntyre, Jonathan E. Shaw, Alyce N. Wilson, Federica Barzi, I-Lynn Lee, Alex Brown, Alison Simmonds, Christine Connors, Louise J. Maple-Brown, Danielle K. Longmore, Jacqueline Boyle, Paula van Dokkum, Longmore, Danielle K, Barr, Elizabeth LM, Wilson, Alyce N, Barzi, Federica, Kirkwood, Marie, Simmonds, Alison, Lee, I Lynn, Hawthorne, Eyvette, Van Dokkum, Paula, Connors, Christine, Boyle, Jacqueline A, Zimmet, Paul, O'Dea, Kerin, Oats, Jeremy, McIntyre, Harold D, Brown, Alex DH, Shaw, Jonathan E, and Maple-Brown, Louise J
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0301 basic medicine ,medicine.medical_specialty ,breastfeeding ,Endocrinology, Diabetes and Metabolism ,Breastfeeding ,030209 endocrinology & metabolism ,Type 2 diabetes ,diabetes associated with pregnancy ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,diabetes ,Obstetrics ,business.industry ,medicine.disease ,Obesity ,Indigenous ,Hospitals ,Gestational diabetes ,Diabetes, Gestational ,030104 developmental biology ,Breast Feeding ,Diabetes Mellitus, Type 2 ,Hyperglycemia ,Cohort ,intergenerational ,Female ,business ,Breast feeding - Abstract
Aims/hypothesis: Women with gestational diabetes mellitus (GDM) and obesity experience lower rates of breastfeeding. Little is known about breastfeeding among mothers with type 2 diabetes. Australian Indigenous women have a high prevalence of type 2 diabetes in pregnancy. We aimed to evaluate the association of hyperglycaemia, including type 2 diabetes, with breastfeeding outcomes. Methods: Indigenous (n = 495) and non-Indigenous (n = 555) participants of the Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort included women without hyperglycaemia in pregnancy (n = 222), with GDM (n = 684) and with type 2 diabetes (n = 144). The associations of hyperglycaemia in pregnancy and breastfeeding at hospital discharge, 6 weeks and 6 months post-partum were evaluated with logistic regression, after adjustment for maternal obesity, ethnicity, maternal and neonatal characteristics. Results: Indigenous women were more likely to predominantly breastfeed at 6 weeks across all levels of hyperglycaemia. Compared with women with no hyperglycaemia in pregnancy, women with type 2 diabetes had lower odds for exclusive breastfeeding at discharge (adjusted OR for exclusive breastfeeding 0.4 [95% CI 0.2, 0.8] p = 0.006). At 6 weeks and 6 months, the relationship between type 2 diabetes and predominant breastfeeding was not statistically significant (6 weeks 0.7 [0.3, 1.6] p = 0.40, 6 months 0.8 [0.4, 1.6] p = 0.60). Women with gestational diabetes were as likely to achieve predominant breastfeeding at 6 weeks and 6 months as women without hyperglycaemia in pregnancy. Conclusions/interpretation: Indigenous women had high rates of breastfeeding. Women with type 2 diabetes had difficulty establishing exclusive breastfeeding at hospital discharge. Further research is needed to assess the impact on long-term breastfeeding outcomes Refereed/Peer-reviewed
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- 2020
8. Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort
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Louise J. Maple-Brown, Federica Barzi, Jacqueline Boyle, Kerin O'Dea, E. L. M. Barr, Christine Connors, Danielle K. Longmore, Jeremy Oats, Marie Kirkwood, Paul Zimmet, H. David McIntyre, I-Lynn Lee, Patrick M. Catalano, Alex Brown, Jonathan E. Shaw, Longmore, Danielle K, Barr, Elizabeth LM, Barzi, Federica, Lee, I Lynn, Kirkwood, Marie, Connors, Christine, Boyle, Jacqueline, O'Dea, Kerin, Zimmet, Paul, Oats, Jeremy, Catalano, Patrick, McIntyre, H David, Brown, Alex DH, Shaw, Jonathan E, and Maple-Brown, Louise J
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Male ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Pregnancy in Diabetics ,Body Mass Index ,Cohort Studies ,0302 clinical medicine ,Endocrinology ,Pregnancy ,Birth Weight ,030212 general & internal medicine ,indigenous ,Maternal Behavior ,Adiposity ,diabetes ,Smoking ,Pregnancy Outcome ,General Medicine ,Gestational diabetes ,socio-economic ,Prenatal Exposure Delayed Effects ,Cohort ,Female ,hyperglycaemia in pregnancy ,Cohort study ,Adult ,neonatal adiposity ,Offspring ,Birth weight ,030209 endocrinology & metabolism ,03 medical and health sciences ,Young Adult ,Population Groups ,Internal Medicine ,medicine ,Humans ,Obesity ,business.industry ,Australia ,Infant, Newborn ,nutritional and metabolic diseases ,medicine.disease ,Diabetes, Gestational ,Diabetes Mellitus, Type 2 ,Socioeconomic Factors ,Hyperglycemia ,Smoking cessation ,business ,Body mass index ,Demography - Abstract
Background: Australian Indigenous women experience high rates of social disadvantage and type 2 diabetes (T2D) in pregnancy, but it is not known how social factors and maternal behaviours impact neonatal adiposity in offspring of women with hyperglycaemia in pregnancy.Methods: Participants were Indigenous (n = 404) and Europid (n = 240) women with gestational diabetes mellitus (GDM) or T2D in pregnancy and their offspring in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. Social, economic factors, and maternal behaviours were measured in pregnancy and six neonatal anthropometric outcomes were examined after birth.Results: On univariate analysis, maternal education < 12 years (p = 0.03), unemployment(p = 0.001), welfare income vs no welfare income (p = 0.001), lower area based socioeconomic score (p < 0.001), and fast food intake > 2 times/week (p = 0.002) were associated with increased sum of skinfolds (SSF) in offspring. Smoking was significantly associated witha reduction in anthropometric measures, except SSF. In multivariable models adjusted for ethnicity, BMI and hyperglycaemia, social and economic factors were no longer significant predictors of neonatal outcomes. Smoking was independently associated with a reduction inlength, head circumference and fat free mass. Frequent fast food intake remained independently associated with SSF (b-coefficient 1.08 mm, p = 0.02).Conclusion: In women with hyperglycaemia in pregnancy, social factors were associated with neonatal adiposity, particularly skinfold measures. Promoting smoking cessation and limited intake of energy-dense, nutrient-poor foods in pregnancy are important to improve neonatal adiposity and lean mass outcomes. Addressing inequities in social and economic factors are likely to be important, particularly for Indigenous women or women experiencing social disadvantage. Refereed/Peer-reviewed
- Published
- 2019
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