1. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on alpha-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats.
- Author
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Gholamhoseinian A, Fallah H, and Sharifi far F
- Subjects
- Acarbose pharmacology, Animals, Hypoglycemic Agents analysis, Hypoglycemic Agents therapeutic use, Kinetics, Male, Plant Extracts pharmacology, Plant Extracts therapeutic use, Postprandial Period drug effects, Rats, Rats, Wistar, Blood Glucose drug effects, Diabetes Mellitus, Experimental drug therapy, Glycoside Hydrolase Inhibitors, Hypoglycemic Agents pharmacology, Phytotherapy, Rosa chemistry
- Abstract
The effect of a methanol extract of Rosa damascena Mill. flowers was studied, in comparison to the alpha-glucosidase inhibitor acarbose, in normal and diabetic rats. The inhibition mode of this extract was examined by measuring enzyme activity in different concentrations of substrate for Lineweaver-Burk plot analysis. The results show that Rosa damascena extract has an intensive inhibitory effect on alpha-glucosidase. Its inhibition was found to be noncompetitive. Oral administration of this plant extract (100 to 1000 mg/kg body wt.) significantly decreased blood glucose after maltose loading in normal and diabetic rats in a dose-dependent manner. These results suggest that Rosa damascena might exert an anti-diabetic effect by suppressing carbohydrate absorption from the intestine and can reduce the postprandial glucose level.
- Published
- 2009
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