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Your search keyword '"GAP-JUNCTION PROTEINS"' showing total 2 results
Start Over Descriptor "GAP-JUNCTION PROTEINS" Topic diabetic wound
2 results on '"GAP-JUNCTION PROTEINS"'

1. Targeting connexin 43 in diabetic wound healing: Future perspectives.

Author

Bajpai, S., Shukla, V. K., Tripathi, K., Srikrishna, S., and Singh, R. K.

Subjects
*MEDICAL research, *CONNEXINS, *ETIOLOGY of diseases, *DIABETES, *ALTERNATIVE medicine, *MANAGEMENT science
Abstract

The unknown mechanisms of impaired tissue repair in diabetes mellitus are making this disease a serious clinical problem for the physicians worldwide. The lacuna in the knowledge of the etiology of diabetic wounds necessitates more focused research in order to develop new targeting tools with higher efficacy for their effective management. Gap-junction proteins, connexins, have shown some promising results in the process of diabetic wound healing. Till now the role of connexins has been implicated in peripheral neuropathy, deafness, skin disorders, cataract, germ cell development and treatment of cancer. Recent findings have revealed that gap junctions play a key role in normal as well as diabetic wound healing. The purpose of this review is to provide the information related to etiology, epidemiology, clinical presentation of diabetic wounds and to analyze the role of connexin 43 (Cx43) in the diabetic wound healing process. The current control strategies and the future research challenges have also been discussed briefly in this review. [ABSTRACT FROM AUTHOR]

Published
2009
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2. Targeting connexin 43 in diabetic wound healing: future perspectives

Author

V K Shukla, Rakesh K. Singh, Kamlakar Tripathi, Surabhi Bajpai, and Saripella Srikrishna

Subjects
medicine.medical_specialty, Connexin, lcsh:Medicine, Disease, Bioinformatics, Impaired tissue repair, Diabetes mellitus, medicine, Diabetes Mellitus, Humans, diabetic wound, Wound Healing, diabetes, business.industry, lcsh:R, Cancer, Gap Junctions, General Medicine, medicine.disease, Diabetic Foot, Surgery, Peripheral neuropathy, Connexin 43, Diabetic wound healing, Etiology, Connexin-43, gap-junction proteins, business
Abstract

The unknown mechanisms of impaired tissue repair in diabetes mellitus are making this disease a serious clinical problem for the physicians worldwide. The lacuna in the knowledge of the etiology of diabetic wounds necessitates more focused research in order to develop new targeting tools with higher efficacy for their effective management. Gap-junction proteins, connexins, have shown some promising results in the process of diabetic wound healing. Till now the role of connexins has been implicated in peripheral neuropathy, deafness, skin disorders, cataract, germ cell development and treatment of cancer. Recent findings have revealed that gap junctions play a key role in normal as well as diabetic wound healing. The purpose of this review is to provide the information related to etiology, epidemiology, clinical presentation of diabetic wounds and to analyze the role of connexin 43 (Cx43) in the diabetic wound healing process. The current control strategies and the future research challenges have also been discussed briefly in this review.

Published
2009

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