1. A novel immune biomarker
- Author
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Benjamin M, Tang, Maryam, Shojaei, Grant P, Parnell, Stephen, Huang, Marek, Nalos, Sally, Teoh, Kate, O'Connor, Stephen, Schibeci, Amy L, Phu, Anand, Kumar, John, Ho, Adrienne F A, Meyers, Yoav, Keynan, Terry, Ball, Amarnath, Pisipati, Aseem, Kumar, Elizabeth, Moore, Damon, Eisen, Kevin, Lai, Mark, Gillett, Robert, Geffers, Hao, Luo, Fahad, Gul, Jens, Schreiber, Sandra, Riedel, David, Booth, Anthony, McLean, and Klaus, Schughart
- Subjects
Male ,Gene Expression ,Membrane Proteins ,Bacterial Infections ,Middle Aged ,Bacterial Physiological Phenomena ,Orthomyxoviridae ,Diagnosis, Differential ,Predictive Value of Tests ,Host-Pathogen Interactions ,Influenza, Human ,Humans ,Female ,Interferons ,Respiratory Tract Infections ,Biomarkers - Abstract
Host response biomarkers can accurately distinguish between influenza and bacterial infection. However, published biomarkers require the measurement of many genes, thereby making it difficult to implement them in clinical practice. This study aims to identify a single-gene biomarker with a high diagnostic accuracy equivalent to multi-gene biomarkers.In this study, we combined an integrated genomic analysis of 1071 individuals with
- Published
- 2015