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Objectives: Subjective tinnitus has associated with abnormal brain metabolism and perfusion found in functional imaging studies by fluorodeoxyglucose (FDG) and technetium99m (TC99m). But there is no study evaluating the association of brain metabolism and perfusion abnormalities in a group of these subjects. The aim of this study was to investigate if there is any significant correlation between the brain perfusion and metabolism abnormalities in subjects with tinnitus. Materials and Methods: In this cross-sectional study, 52 patients were undergone TC99m-ECD single photon emission computerized tomography (SPECT) scan and F18-FDG positron emission tomography (PET). The results of PET and SPECT scanning were fused with MRI to accurate anatomical localization of abnormalities. The analysis was performed using Kendal’s correlation, t-test and chi square. Results: Assessing these 52 tinnitus subjects (containing 42 males [76.4%]) showed that a significant correlation was found between the brain metabolic function and perfusion (p value 0.001). [ABSTRACT FROM AUTHOR]

Introduction: The aim of the present study was to evaluate technetium-99m sestamibi single photon emission tomography (SPECT) myocardial perfusion imaging (MPI) and its association with some clinical and laboratory parameters in an asymptomatic systemic lupus erythematosus (SLE) population.Materials and Methods : Twenty-one subjects with SLE and no suspected or documented coronary artery disease (CAD) accomplished myocardial perfusion imaging. Some SLE and CAD parameters were also evaluated in association with myocardial SPECT.Results: Twenty-one women with a diagnosis of SLE (mean age 36.9 ± 12.8) entered the study. All patients were in the low-risk category for CAD pretest; however, abnormal myocardial perfusion results were found in eight (38%) patients. Amongst the traditional CAD risk factors, there was a significant association between the presence of dyslipidemia and myocardial perfusion abnormalities (P= 0.047). However, we found no significant association between other traditional and SLE-specific risk factors.Conclusion: This study’s significant finding was that asymptomatic CAD is common in SLE patients, even in those thought to be low risk for CAD and in the absence of cardiac symptoms. [ABSTRACT FROM PUBLISHER]